Search Results - "Bellos, Frauke"

Flow cytometry in the diagnosis of myelodysplastic syndromes and the value of myeloid nuclear differentiation antigen by Bellos, Frauke, Kern, Wolfgang

“…Background Confirming diagnosis of myelodysplastic syndromes (MDS) is often challenging. Standard diagnostic methods are cytomorphology (CM) and cytogenetics…”
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The molecular profile of adult T-cell acute lymphoblastic leukemia: Mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL by Grossmann, Vera, Haferlach, Claudia, Weissmann, Sandra, Roller, Andreas, Schindela, Sonja, Poetzinger, Franziska, Stadler, Kathrin, Bellos, Frauke, Kern, Wolfgang, Haferlach, Torsten, Schnittger, Susanne, Kohlmann, Alexander

“…T‐cell acute lymphoblastic leukemia (T‐ALL) is an aggressive and heterogeneous disease. The diagnosis is predominantly based on immunophenotyping. In addition…”
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Automated Comprehensive Diagnostics of Hematologic Neoplasms By Artificial Intelligence Models Using Flow Cytometric Raw Matrix Data by Bellos, Frauke, Pawelka, Kim, Fortina, Elena, Suriyalaksh, Manusnan, Maschek, Sven, Haferlach, Claudia, Meggendorfer, Manja, Haferlach, Torsten, Kern, Wolfgang

“…Abstract Background: Artificial intelligence (AI) has steadily been entering the field supporting diagnostic workup of hematological neoplasms. Its application…”
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Incidential Findings of Mutations in the PIGA Gene Are Highly Specific for the Presence of PNH Clones by Hoermann, Gregor, Nadarajah, Niroshan, Baer, Constance, Dicker, Frank, Loy, Kristina, Delic, Sabit, Bellos, Frauke, Haferlach, Claudia, Meggendorfer, Manja, Haferlach, Torsten, Kern, Wolfgang

“…Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic anemia associated with severe thrombophilia and characterized by complement-mediated lysis…”
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Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93 by Mühlbacher, Verena, Zenger, Melanie, Schnittger, Susanne, Weissmann, Sandra, Kunze, Franziska, Kohlmann, Alexander, Bellos, Frauke, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia

“…B lymphoblastic leukemia/lymphoma (ALL) are subdivided by the WHO classification into five subgroups defined by specific translocations and two further…”
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Valproic acid and all-trans retinoic acid: meta-analysis of a palliative treatment regimen in AML and MDS patients by Bellos, Frauke, Mahlknecht, Ulrich

“…Currently, no standard treatment is available for elderly patients with de novo/secondary acute myeloid leukemia (AML) who are not eligible for intensive…”
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ELN IMDS Flow Working Group Validation of the Monocyte Assay for Chronic Myelomonocytic Leukemia Diagnosis By Flow Cytometry by Wagner-Ballon, Orianne, Bettelheim, Peter, Lauf, Jeroen, Bellos, Frauke, Della Porta, Matteo G., Travaglino, Erica, Subirá, Dolores, Nuevo, Irene, Tarfi, Sihem, Westers, Theresia M., Johansson, Ulrika, Psarra, Katherina, Karathanos, Serafeim, Matarraz, Sergio, Colado, Enrique, Gupta, Monali, Ireland, Robin M., Kern, Wolfgang, van de Loosdrecht, Arjan

“…▪ Introduction It was proposed that peripheral blood (PB) monocyte subset analysis evaluated by flow cytometry, hereafter referred to as “monocyte assay”,…”
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Multicenter Prospective Evaluation of Diagnostic Potential of Flow Cytometric Aberrancies in Myelodysplastic Syndromes by Kern, Wolfgang, Westers, Theresia M., Bellos, Frauke, Bene, Marie C, Bettelheim, Peter, Eidenschink Brodersen, Lisa, Burbury, Kate, Chu, Sung-Chao, Cullen, Matthew, Porta, Matteo Della, Dunlop, Alan Stewart, Johansson, Ulrika, Matarraz, Sergio, Oelschlaegel, Uta, Ogata, Kiyoyuki, Porwit, Anna, Preijers, Frank W.M.B., Psarra, Katherina, Saft, Leonie, Subirá, Dolores, Weiss, Elisabeth, Van de Loosdrecht, Arjan A.

“…Background: Myelodysplastic syndromes (MDS) are considered clonal diseases and are diagnosed according to WHO by cytomorphology and cytogenetics. The…”
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ELN iMDS flow working group validation of the monocyte assay for chronic myelomonocytic leukemia diagnosis by flow cytometry by Wagner‐Ballon, Orianne, Bettelheim, Peter, Lauf, Jeroen, Bellos, Frauke, Della Porta, Matteo, Travaglino, Erica, Subira, Dolores, Lopez, Irene Nuevo, Tarfi, Sihem, Westers, Theresia M., Johansson, Ulrika, Psarra, Katherina, Karathanos, Serafeim, Matarraz, Sergio, Colado, Enrique, Gupta, Monali, Ireland, Robin, Kern, Wolfgang, Van De Loosdrecht, Arjan A.

“…Background: It was proposed that peripheral blood (PB) monocyte profiles evaluated by flow cytometry, called “monocyte assay,” could rapidly and efficiently…”
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Outcome of high-risk acute myeloid leukemia after allogeneic hematopoietic cell transplantation: negative impact of abnl(17p) and −5/5q by Middeke, Jan M., Beelen, Dietrich, Stadler, Michael, Göhring, Gudrun, Schlegelberger, Brigitte, Baurmann, Herrad, Bug, Gesine, Bellos, Frauke, Mohr, Brigitte, Buchholz, Stefanie, Schwerdtfeger, Rainer, Martin, Hans, Hegenbart, Ute, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes

“…The European LeukemiaNet classification combines a heterogeneous group of aberrations as adverse-risk abnormalities. Our goal was to investigate the outcomes…”
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Correlation of CD30 Expression on Neoplastic Mast Cells in Systemic Mastocytosis Assessed By Immunohistochemistry Versus Multiparameter Flow Cytometry and Correlation to Clinical Parameters by Bellos, Frauke, Sotlar, Karl, Schnittger, Susanne, Haferlach, Claudia, Haferlach, Torsten, Kern, Wolfgang

“…Background: Systemic mastocytosis (SM) is rarely diagnosed and presents with highly variable clinical manifestation from taking rather indolent to very…”
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Myeloid Nuclear Differentiation Antigen (MNDA) Expression: A Useful Marker in the Diagnosis of Myelodysplastic Syndromes By Flow Cytometry by Bellos, Frauke, Haferlach, Torsten, Davis, Bruce H., Haferlach, Claudia, Schnittger, Susanne, Kern, Wolfgang

“…Background: Diagnostic workup for suspected myelodysplastic syndromes (MDS) is increasingly done with the aid of multiparamter flow cytometry (MFC) detecting…”
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Flow cytometry in the diagnosis of myelodysplastic syndromes (MDS) and the value of myeloid nuclear differentiation antigen (MNDA) by Bellos, Frauke, Kern, Wolfgang

“…Background: Confirming diagnosis of myelodysplastic syndromes (MDS) is often challenging. Standard diagnostic methods are cytomorphology (CM) and cytogenetics…”
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Flow cytometric analysis of myelodysplasia: Pre‐analytical and technical issues—Recommendations from the European LeukemiaNet by Velden, Vincent H. J., Preijers, Frank, Johansson, Ulrika, Westers, Theresia M., Dunlop, Alan, Porwit, Anna, Béné, Marie C., Valent, Peter, Marvelde, Jeroen, Wagner‐Ballon, Orianne, Oelschlaegel, Uta, Saft, Leonie, Kordasti, Sharham, Ireland, Robin, Cremers, Eline, Alhan, Canan, Duetz, Carolien, Hobo, Willemijn, Chapuis, Nicolas, Fontenay, Michaela, Bettelheim, Peter, Eidenshink‐Brodersen, Lisa, Font, Patricia, Loken, Michael R., Matarraz, Sergio, Ogata, Kiyoyuki, Orfao, Alberto, Psarra, Katherina, Subirá, Dolores, Wells, Denise A., Della Porta, Matteo G., Burbury, Kate, Bellos, Frauke, Weiß, Elisabeth, Kern, Wolfgang, Loosdrecht, Arjan

“…Background Flow cytometry (FCM) aids the diagnosis and prognostic stratification of patients with suspected or confirmed myelodysplastic syndrome (MDS). Over…”
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Clinical application of flow cytometry in patients with unexplained cytopenia and suspected myelodysplastic syndrome: A report of the European LeukemiaNet International MDS‐Flow Cytometry Working Group by Loosdrecht, Arjan A., Kern, Wolfgang, Porwit, Anna, Valent, Peter, Kordasti, Sharham, Cremers, Eline, Alhan, Canan, Duetz, Carolien, Dunlop, Alan, Hobo, Willemijn, Preijers, Frank, Wagner‐Ballon, Orianne, Chapuis, Nicolas, Fontenay, Michaela, Bettelheim, Peter, Eidenschink‐Brodersen, Lisa, Font, Patricia, Johansson, Ulrika, Loken, Michael R., Marvelde, Jeroen G., Matarraz, Sergio, Ogata, Kiyoyuki, Oelschlaegel, Uta, Orfao, Alberto, Psarra, Katherina, Subirá, Dolores, Wells, Denise A., Béné, Marie C., Della Porta, Matteo G., Burbury, Kate, Bellos, Frauke, Velden, Vincent H. J., Westers, Theresia M., Saft, Leonie, Ireland, Robin

“…This article discusses the rationale for inclusion of flow cytometry (FCM) in the diagnostic investigation and evaluation of cytopenias of uncertain origin and…”
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Multicenter prospective evaluation of diagnostic potential of flow cytometric aberrancies in myelodysplastic syndromes by the ELN iMDS flow working group by Kern, Wolfgang, Westers, Theresia M., Bellos, Frauke, Bene, Marie Christine, Bettelheim, Peter, Brodersen, Lisa Eidenschink, Burbury, Kate, Chu, Sung‐Chao, Cullen, Matthew, Porta, Matteo Della, Dunlop, Alan Stewart, Johansson, Ulrika, Matarraz, Sergio, Oelschlaegel, Uta, Ogata, Kiyoyuki, Porwit, Anna, Preijers, Frank, Psarra, Katherina, Saft, Leonie, Subirá, Dolores, Weiß, Elisabeth, Velden, Vincent H. J., Loosdrecht, Arjan

“…Background Myelodysplastic syndromes (MDS) represent a diagnostic challenge. This prospective multicenter study was conducted to evaluate pre‐defined flow…”
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Multiparameter flow cytometry in the evaluation of myelodysplasia: Analytical issues by Porwit, Anna, Béné, Marie C., Duetz, Carolien, Matarraz, Sergio, Oelschlaegel, Uta, Westers, Theresia M., Wagner‐Ballon, Orianne, Kordasti, Shahram, Valent, Peter, Preijers, Frank, Alhan, Canan, Bellos, Frauke, Bettelheim, Peter, Burbury, Kate, Chapuis, Nicolas, Cremers, Eline, Della Porta, Matteo G., Dunlop, Alan, Eidenschink‐Brodersen, Lisa, Font, Patricia, Fontenay, Michaela, Hobo, Willemijn, Ireland, Robin, Johansson, Ulrika, Loken, Michael R., Ogata, Kiyoyuki, Orfao, Alberto, Psarra, Katherina, Saft, Leonie, Subira, Dolores, Marvelde, Jeroen, Wells, Denise A., Velden, Vincent H. J., Kern, Wolfgang, Loosdrecht, Arjan A.

“…Multiparameter flow cytometry (MFC) is one of the essential ancillary methods in bone marrow (BM) investigation of patients with cytopenia and suspected…”
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Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance by Ran, Dan, Schubert, Mario, Taubert, Isabel, Eckstein, Volker, Bellos, Frauke, Jauch, Anna, Chen, Hui, Bruckner, Thomas, Saffrich, Rainer, Wuchter, Patrick, Ho, Anthony D

“…Leukemia stem cell candidates (LSCC) can be enriched from patients with acute myeloid leukemia by high aldehyde dehydrogenase (ALDH) activity and CD34…”
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Inhibition of PLK1 by capped‐dose volasertib exerts substantial efficacy in MDS and sAML while sparing healthy haematopoiesis by Dill, Veronika, Kauschinger, Johanna, Hauch, Richard T., Buschhorn, Lars, Odinius, Timo O., Müller‐Thomas, Catharina, Mishra, Ritu, Kyncl, Michele C., Schmidt, Burkhard, Prodinger, Peter M., Hempel, Dirk, Bellos, Frauke, Höllein, Alexander, Kern, Wolfgang, Haferlach, Torsten, Slotta‐Huspenina, Julia, Bassermann, Florian, Peschel, Christian, Götze, Katharina S., Waizenegger, Irene C., Höckendorf, Ulrike, Jost, Philipp J., Jilg, Stefanie

“…Introduction Targeting the cell cycle machinery represents a rational therapeutic approach in myelodysplastic syndromes (MDS) and secondary acute myeloid…”
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Visceral leishmaniasis in a patient with relapsed multiple myeloma receiving high-dose melphalan and autologous stem cell transplant by Radujkovic, Aleksandar, Hundemer, Michael, Eisenbach, Christoph, Luft, Thomas, Penzel, Roland, Goldschmidt, Hartmut, Ho, Anthony D., Bellos, Frauke

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