Search Results - "Bellora, Francesca"

Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues by Castriconi, Roberta, Carrega, Paolo, Dondero, Alessandra, Bellora, Francesca, Casu, Beatrice, Regis, Stefano, Ferlazzo, Guido, Bottino, Cristina

“…A large body of data shows that Natural Killer (NK) cells are immune effectors exerting a potent cytolytic activity against tumors and virus infected cells…”
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Mesenchymal Stromal Cells Induce Peculiar Alternatively Activated Macrophages Capable of Dampening Both Innate and Adaptive Immune Responses by Chiossone, Laura, Conte, Romana, Spaggiari, Grazia Maria, Serra, Martina, Romei, Cristina, Bellora, Francesca, Becchetti, Flavio, Andaloro, Antonio, Moretta, Lorenzo, Bottino, Cristina

“…Mesenchymal stromal cells (MSCs) support hematopoiesis and exert immunoregulatory activities. Here, we analyzed the functional outcome of the interactions…”
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Neuroblastoma-derived TGF-β1 modulates the chemokine receptor repertoire of human resting NK cells by Castriconi, Roberta, Dondero, Alessandra, Bellora, Francesca, Moretta, Lorenzo, Castellano, Aurora, Locatelli, Franco, Corrias, Maria Valeria, Moretta, Alessandro, Bottino, Cristina

“…In this study, we show that neuroblastoma (NB) cell conditioning affects the chemokine receptor repertoire of human resting NK cells. In particular, NB cells…”
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The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes by Bellora, Francesca, Castriconi, Roberta, Dondero, Alessandra, Reggiardo, Giorgio, Moretta, Lorenzo, Mantovani, Alberto, Moretta, Alessandro, Bottino, Cristina, Yokoyama, Wayne M.

“…The cross-talk among cells of the innate immunity can greatly affect both innate and adaptive responses. Here we analyzed the molecular interactions between…”
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TLR activation of tumor‐associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells by Bellora, Francesca, Castriconi, Roberta, Dondero, Alessandra, Pessino, Anna, Nencioni, Alessio, Liggieri, Giovanni, Moretta, Lorenzo, Mantovani, Alberto, Moretta, Alessandro, Bottino, Cristina

“…We analyzed the functional outcome of the interaction between tumor‐associated macrophages (TAMs) and natural killer (NK) cells. TAMs from ascites of ovarian…”
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Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages by Bellora, Francesca, Dondero, Alessandra, Corrias, Maria Valeria, Casu, Beatrice, Regis, Stefano, Caliendo, Fabio, Moretta, Alessandro, Cazzola, Mario, Elena, Chiara, Vinti, Luciana, Locatelli, Franco, Bottino, Cristina, Castriconi, Roberta

“…Tyrosine kinase inhibitors (TKIs) are used in the clinical management of hematological neoplasms. Moreover, in solid tumors such as stage 4 neuroblastomas…”
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PD-L1 expression in metastatic neuroblastoma as an additional mechanism for limiting immune surveillance by Dondero, Alessandra, Pastorino, Fabio, Della Chiesa, Mariella, Corrias, Maria Valeria, Morandi, Fabio, Pistoia, Vito, Olive, Daniel, Bellora, Francesca, Locatelli, Franco, Castellano, Aurora, Moretta, Lorenzo, Moretta, Alessandro, Bottino, Cristina, Castriconi, Roberta

“…The prognosis of high-risk neuroblastoma (NB) remains poor, although immunotherapies with anti-GD2 antibodies have been reported to provide some benefit…”
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M‐CSF induces the expression of a membrane‐bound form of IL‐18 in a subset of human monocytes differentiating in vitro toward macrophages by Bellora, Francesca, Castriconi, Roberta, Doni, Andrea, Cantoni, Claudia, Moretta, Lorenzo, Mantovani, Alberto, Moretta, Alessandro, Bottino, Cristina

“…IL‐18 is a proinflammatory cytokine belonging to the “IL‐1 family” that has been shown to play a prominent role in the induction of type 1 immune responses…”
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Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages by Marengo, Barbara, Bellora, Francesca, Ricciarelli, Roberta, De Ciucis, Chiara, Furfaro, AnnaLisa, Leardi, Riccardo, Colla, Renata, Pacini, Davide, Traverso, Nicola, Moretta, Alessandro, Pronzato, Maria Adelaide, Bottino, Cristina, Domenicotti, Cinzia

“…Macrophages play a crucial role in atherosclerosis progression. Classically activated M1 macrophages have been found in rupture‐prone atherosclerotic plaques…”
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Both CD133⁺ and CD133⁻ medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity by Castriconi, Roberta, Dondero, Alessandra, Negri, Francesca, Bellora, Francesca, Nozza, Paolo, Carnemolla, Barbara, Raso, Alessandro, Moretta, Lorenzo, Moretta, Alessandro, Bottino, Cristina

“…Adoptive cellular immunotherapy has been proposed as an additional treatment of medulloblastoma, an intracranial tumor characterized by a particularly poor…”
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Main NK cell receptors and their ligands: regulation by microRNAs by Regis, Stefano, Caliendo, Fabio, Dondero, Alessandra, Bellora, Francesca, Casu, Beatrice, Bottino, Cristina, Castriconi, Roberta

“…The NK cells functions are finely tuned by several kinds of inhibitory and activating receptors, whose pattern of expression characterizes different NK…”
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Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells by Falco, Michela, Marcenaro, Emanuela, Romeo, Elisa, Bellora, Francesca, Marras, Daniele, Vély, Frédéric, Ferracci, Géraldine, Moretta, Lorenzo, Moretta, Alessandro, Bottino, Cristina

“…NK‐T‐B antigen (NTBA) is a CD2 family member that functions as a coreceptor in human NK cell activation. Several receptor/ligand interactions occur between…”
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GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues by Della Chiesa, Mariella, Falco, Michela, Parolini, Silvia, Bellora, Francesca, Petretto, Andrea, Romeo, Elisa, Balsamo, Mirna, Gambarotti, Marco, Scordamaglia, Francesca, Tabellini, Giovanna, Facchetti, Fabio, Vermi, William, Bottino, Cristina, Moretta, Alessandro, Vitale, Massimo

“…To define novel human NK cell markers, we generated two mAbs specific for G-protein-coupled receptor 56 (GPR56), a surface glycoprotein that appears to be…”
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Neuroblastoma-Derived TGF- beta 1 Modulates the Chemokine Receptor Repertoire of Human Resting NK Cells by Castriconi, Roberta, Dondero, Alessandra, Bellora, Francesca, Moretta, Lorenzo, Castellano, Aurora, Locatelli, Franco, Corrias, Maria Valeria, Moretta, Alessandro, Bottino, Cristina

“…In this study, we show that neuroblastoma (NB) cell conditioning affects the chemokine receptor repertoire of human resting NK cells. In particular, NB cells…”
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NK Cells Recognize and Kill Human Glioblastoma Cells with Stem Cell-Like Properties by Castriconi, Roberta, Daga, Antonio, Dondero, Alessandra, Zona, Gianluigi, Poliani, Pietro Luigi, Melotti, Alice, Griffero, Fabrizio, Marubbi, Daniela, Spaziante, Renato, Bellora, Francesca, Moretta, Lorenzo, Moretta, Alessandro, Corte, Giorgio, Bottino, Cristina

“…In this study, cancer cells were isolated from tumor specimens of nine glioblastoma patients. Glioblastoma cells, cultured under suitable culture conditions,…”
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Human NK cells and NK receptors by Bellora, Francesca, Castriconi, Roberta, Dondero, Alessandra, Carrega, Paolo, Mantovani, Alberto, Ferlazzo, Guido, Moretta, Alessandro, Bottino, Cristina

“…Highlights • Human NK cells make important contributions to both innate and adaptive immunity. • NK cells exert potent cytolytic activity against tumor of…”
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Novel Immunoregulatory Functions of IL-18, an Accomplice of TGF-β1 by Casu, Beatrice, Dondero, Alessandra, Regis, Stefano, Caliendo, Fabio, Petretto, Andrea, Bartolucci, Martina, Bellora, Francesca, Bottino, Cristina, Castriconi, Roberta

“…TGF-β1 is a pleiotropic factor exerting a strong regulatory role in several cell types, including immune cells. In NK cells it profoundly alters the surface…”
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Natural killer cells and neuroblastoma: tumor recognition, escape mechanisms, and possible novel immunotherapeutic approaches by Bottino, Cristina, Dondero, Alessandra, Bellora, Francesca, Moretta, Lorenzo, Locatelli, Franco, Pistoia, Vito, Moretta, Alessandro, Castriconi, Roberta

“…Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and arises from developing sympathetic nervous system. Most primary tumors…”
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Inhibitory 2B4 contributes to NK cell education and immunological derangements in XLP1 patients by Meazza, Raffaella, Falco, Michela, Marcenaro, Stefania, Loiacono, Fabrizio, Canevali, Paolo, Bellora, Francesca, Tuberosa, Claudia, Locatelli, Franco, Micalizzi, Concetta, Moretta, Alessandro, Mingari, Maria C., Moretta, Lorenzo, Aricò, Maurizio, Bottino, Cristina, Pende, Daniela

“…X‐linked lymphoproliferative disease 1 (XLP1) is an inherited immunodeficiency, caused by mutations in SH2D1A encoding Signaling Lymphocyte Activation Molecule…”
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NK cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of IL-27 by Dondero, Alessandra, Casu, Beatrice, Bellora, Francesca, Vacca, Angelo, De Luisi, Annunziata, Frassanito, Maria Antonia, Cantoni, Claudia, Gaggero, Silvia, Olive, Daniel, Moretta, Alessandro, Bottino, Cristina, Castriconi, Roberta

“…Angiogenesis represents a hallmark of tumor progression in Multiple Myeloma (MM), a still incurable malignancy. Here we analyzed the activity of…”
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