Search Results - "Bellocq, C."

Transferrin-Containing, Cyclodextrin Polymer-Based Particles for Tumor-Targeted Gene Delivery by Bellocq, Nathalie C, Pun, Suzie H, Jensen, Gregory S, Davis, Mark E

“…Transferrin is a well-studied ligand for tumor targeting due to upregulation of transferrin receptors in numerous cancer cell types. Here, we report the…”
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Cyclodextrin-Modified Polyethylenimine Polymers for Gene Delivery by Pun, Suzie H, Bellocq, Nathalie C, Liu, Aijie, Jensen, Greg, Machemer, Todd, Quijano, Erlinda, Schluep, Thomas, Wen, Shufen, Engler, Heidrun, Heidel, Jeremy, Davis, Mark E

“…Linear and branched poly(ethylenimines), lPEI and bPEI, respectively, grafted with β-cyclodextrin are prepared to give CD−lPEI and CD−bPEI, respectively, and…”
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Effects of Structure of β-Cyclodextrin-Containing Polymers on Gene Delivery by Hwang, Suzie J, Bellocq, Nathalie C, Davis, Mark E

“…Linear cationic β-cyclodextrin-based polymers (βCDPs) are capable of forming polyplexes with nucleic acids and transfecting cultured cells. The βCDPs are…”
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Structure−Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Nonviral Gene Delivery by Cheng, Jianjun, Zeidan, Ryan, Mishra, Swaroop, Liu, Aijie, Pun, Suzie H, Kulkarni, Rajan P, Jensen, Gregory S, Bellocq, Nathalie C, Davis, Mark E

“…To understand how chloroquine (CQ) enhances transgene expression in polycation-based, nonviral gene delivery systems, a number of CQ analogues with variations…”
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Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels by Loussouarn, G., Park, K.-H., Bellocq, C., Baró, I., Charpentier, F., Escande, D.

“…Phosphatidylinositol‐4,5‐bisphosphate (PIP2) is a major signaling molecule implicated in the regulation of various ion transporters and channels. Here we show…”
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Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles by Pun, Suzie H., Tack, Frederik, Bellocq, Nathalie C., Cheng, Jianjun, Grubbs, Brendan H., Jensen, Gregory S., Davis, Mark E., Brewster, Marcus, Janicot, Michel, Janssens, Boudewijn, Floren, Wim, Bakker, Annette

“…Short nucleic acid sequences specific to oncogene targets such as bcl-2, bcr-abl, and c-myc have been shown to exhibit specific anti-cancer activity in vitro…”
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Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers by Davis, M E, Pun, S H, Bellocq, N C, Reineke, T M, Popielarski, S R, Mishra, S, Heidel, J D

“…Non-viral (synthetic) nucleic acid delivery systems have the potential to provide for the practical application of nucleic acid-based therapeutics. We have…”
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Synthetic Biocompatible Cyclodextrin-Based Constructs for Local Gene Delivery to Improve Cutaneous Wound Healing by Bellocq, Nathalie C, Kang, David W, Wang, Xuehui, Jensen, Gregory S, Pun, Suzie H, Schluep, Thomas, Zepeda, Monica L, Davis, Mark E

“…The localized, sustained delivery of growth factors for wound healing therapy is actively being explored by gene transfer to the wound site. Biocompatible…”
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A common antitussive drug, clobutinol, precipitates the long QT syndrome 2 by Bellocq, Chloé, Wilders, Ronald, Schott, Jean-Jacques, Louérat-Oriou, Bénédicte, Boisseau, Pierre, Le Marec, Hervé, Escande, Denis, Baró, Isabelle

“…QT prolongation, a classic risk factor for arrhythmias, can result from a mutation in one of the genes governing cardiac repolarization and also can result…”
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Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart by Le Bouter, Sabrina, El Harchi, Aziza, Marionneau, Céline, Bellocq, Chloé, Chambellan, Arnaud, van Veen, Toon, Boixel, Christophe, Gavillet, Bruno, Abriel, Hugues, Le Quang, Khai, Chevalier, Jean-Christophe, Lande, Gilles, Léger, Jean J, Charpentier, Flavien, Escande, Denis, Demolombe, Sophie

“…The basis for the unique effectiveness of long-term amiodarone treatment on cardiac arrhythmias is incompletely understood. The present study investigated the…”
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Human Kv1.6 current displays a C-type-like inactivation when re-expressed in cos-7 cells by Guihard, G, Bellocq, C, Grelet, E, Escande, D

“…The human Kv1.6 K + channel was functionally re-expressed in COS-7 cells at different levels. Voltage-activated K + currents are recorded upon cell membrane…”
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Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity by ROYER, Anne, DEMOLOMBE, Sophie, MOTOIKE, Howard K, CHEVALLIER, Jean-Christophe, LOUSSOUAM, Gildas, CLANCY, Colleen E, ESCANDE, Denis, CHARPENTIER, Flavien, AZIZA EL HARCHI, KHAÏ LE QUANG, PIRON, Julien, TOUMANIANTZ, Gilles, MAZURAIS, David, BELLOCQ, Chloé, LANDE, Gilles, TERRENOIRE, Cécile

“…The K(+) channel encoded by the human ether-a-go-go-related gene (HERG) is crucial for repolarization in the human heart. In order to investigate the impact of…”
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New KCNQ1 mutations leading to haploinsufficiency in a general population1Defective trafficking of a KvLQT1 mutant by GOUAS, L, BELLOCQ, C, BERTHET, M, POTET, F, DEMOLOMBE, S, FORHAN, A, LESCASSE, R, SIMON, F, BALKAU, B, DENJOY, I

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Cyclodextrin-Containing Polymers for Gene Delivery by Davis, Mark E, Bellocq, Nathalie C

“…Cyclodextrin-containing polymers are now being explored as vehicles for delivering nucleic acids into cells. The structures of the cyclodextrin-containing…”
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Mutation in KCNQ1 that has both recessive and dominant characteristics by Murray, A, Potet, F, Bellocq, C, Baró, I, Reardon, W, Hughes, H E, Jeffery, S

“…Mutations in KCNQ1 produce JLNS as well as RWS, 10- 12 although in the latter case there appears to be a strongly dominant negative effect exerted by the…”
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A role of Sep1 (= Kem1, Xrn1) as a microtubule‐associated protein in Saccharomyces cerevisiae by Interthal, H., Bellocq, C., Bähler, J., Bashkirov, V.I., Edelstein, S., Heyer, W.D.

“…Saccharomyces cerevisiae cells lacking the SEP1 (also known as XRN1, KEM1, DST2, RAR5) gene function exhibit a number of phenotypes in cellular processes…”
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Mutation in the KCNQ1 gene leading to the short QT-interval syndrome by BELLOCQ, Chloé, VAN GINNEKEN, Antoni C. G, BEZZINA, Connie R, ALDERS, Mariel, ESCANDE, Denis, MANNENS, Marcel M. A. M, BARO, Isabelle, WILDE, Arthur A. M

“…The electrocardiographic short QT-interval syndrome forms a distinct clinical entity presenting with a high rate of sudden death and exceptionally short QT…”
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Translational requirement for La Crosse virus S-mRNA synthesis: a possible mechanism by BELLOCQ, C, KOLAKOFSKY, D

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Translational requirement of La Crosse virus S-mRNA synthesis: in vitro studies by BELLOCQ, C, RAJU, R, PATTERSON, J, KOLAKOFSKY, D

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Intratypic recombination of polioviruses: evidence for multiple crossing-over sites on the viral genome by AGUT, H, KEAN, K. M, BELLOCQ, C, FICHOT, O, GIRARD, M

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