Search Results - "Bellenguez, C"

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology by Dourlen, P, Fernandez-Gomez, F J, Dupont, C, Grenier-Boley, B, Bellenguez, C, Obriot, H, Caillierez, R, Sottejeau, Y, Chapuis, J, Bretteville, A, Abdelfettah, F, Delay, C, Malmanche, N, Soininen, H, Hiltunen, M, Galas, M-C, Amouyel, P, Sergeant, N, Buée, L, Lambert, J-C, Dermaut, B

“…A recent genome-wide association meta-analysis for Alzheimer’s disease (AD) identified 19 risk loci (in addition to APOE ) in which the functional genes are…”
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Whole-Exome Sequencing in the Isolated Populations of Cilento from South Italy by Nutile, T., Ruggiero, D., Herzig, A. F., Tirozzi, A., Nappo, S., Sorice, R., Marangio, F., Bellenguez, C., Leutenegger, A. L., Ciullo, M.

“…The present study describes the genetic architecture of the isolated populations of Cilento, through the analysis of exome sequence data of 245 representative…”
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Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology by Chapuis, J, Hansmannel, F, Gistelinck, M, Mounier, A, Van Cauwenberghe, C, Kolen, K V, Geller, F, Sottejeau, Y, Harold, D, Dourlen, P, Grenier-Boley, B, Kamatani, Y, Delepine, B, Demiautte, F, Zelenika, D, Zommer, N, Hamdane, M, Bellenguez, C, Dartigues, J-F, Hauw, J-J, Letronne, F, Ayral, A-M, Sleegers, K, Schellens, A, Broeck, L V, Engelborghs, S, De Deyn, P P, Vandenberghe, R, O'Donovan, M, Owen, M, Epelbaum, J, Mercken, M, Karran, E, Bantscheff, M, Drewes, G, Joberty, G, Campion, D, Octave, J-N, Berr, C, Lathrop, M, Callaerts, P, Mann, D, Williams, J, Buée, L, Dewachter, I, Van Broeckhoven, C, Amouyel, P, Moechars, D, Dermaut, B, Lambert, J-C

“…Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer’s…”
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Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21 by Spencer, Chris C A, Plagnol, Vincent, Strange, Amy, Gardner, Michelle, Paisan-Ruiz, Coro, Band, Gavin, Barker, Roger A, Bellenguez, Celine, Bhatia, Kailash, Blackburn, Hannah, Blackwell, Jennie M, Bramon, Elvira, Brown, Martin A, Brown, Matthew A, Burn, David, Casas, Juan-Pablo, Chinnery, Patrick F, Clarke, Carl E, Corvin, Aiden, Craddock, Nicholas, Deloukas, Panos, Edkins, Sarah, Evans, Jonathan, Freeman, Colin, Gray, Emma, Hardy, John, Hudson, Gavin, Hunt, Sarah, Jankowski, Janusz, Langford, Cordelia, Lees, Andrew J, Markus, Hugh S, Mathew, Christopher G, McCarthy, Mark I, Morrison, Karen E, Palmer, Colin N A, Pearson, Justin P, Peltonen, Leena, Pirinen, Matti, Plomin, Robert, Potter, Simon, Rautanen, Anna, Sawcer, Stephen J, Su, Zhan, Trembath, Richard C, Viswanathan, Ananth C, Williams, Nigel W, Morris, Huw R, Donnelly, Peter, Wood, Nicholas W

“…We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD…”
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17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression by Le Guennec, K, Quenez, O, Nicolas, G, Wallon, D, Rousseau, S, Richard, A-C, Alexander, J, Paschou, P, Charbonnier, C, Bellenguez, C, Grenier-Boley, B, Lechner, D, Bihoreau, M-T, Olaso, R, Boland, A, Meyer, V, Deleuze, J-F, Amouyel, P, Munter, H M, Bourque, G, Lathrop, M, Frebourg, T, Redon, R, Letenneur, L, Dartigues, J-F, Martinaud, O, Kalev, O, Mehrabian, S, Traykov, L, Ströbel, T, Le Ber, I, Caroppo, P, Epelbaum, S, Jonveaux, T, Pasquier, F, Rollin-Sillaire, A, Génin, E, Guyant-Maréchal, L, Kovacs, G G, Lambert, J-C, Hannequin, D, Campion, D, Rovelet-Lecrux, A

“…To assess the role of rare copy number variations in Alzheimer's disease (AD), we conducted a case–control study using whole-exome sequencing data from 522…”
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Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways: Alzheimers Dement by Sherva, R., Gross, A., Mukherjee, S., Koesterer, R., Amouyel, P., Bellenguez, C., Dufouil, Carole, Bennett, D. A., Chibnik, L., Cruchaga, C., Del-Aguila, J., Farrer, L. A., Mayeux, R., Munsie, L., Winslow, A., Newhouse, S., Saykin, A. J., Kauwe, J. S. K., Crane, P. K., Green, R. C.

“…IntroductionVariability exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed a genome‐wide association study to examine rate…”
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Follow-up of loci from the International Genomics of Alzheimer’s Disease Project identifies TRIP4 as a novel susceptibility gene by Ruiz, A, Heilmann, S, Becker, T, Hernández, I, Wagner, H, Thelen, M, Mauleón, A, Rosende-Roca, M, Bellenguez, C, Bis, J C, Harold, D, Gerrish, A, Sims, R, Sotolongo-Grau, O, Espinosa, A, Alegret, M, Arrieta, J L, Lacour, A, Leber, M, Becker, J, Lafuente, A, Ruiz, S, Vargas, L, Rodríguez, O, Ortega, G, Dominguez, M-A, Mayeux, R, Haines, J L, Pericak-Vance, M A, Farrer, L A, Schellenberg, G D, Chouraki, V, Launer, L J, van Duijn, C, Seshadri, S, Antúnez, C, Breteler, M M, Serrano-Ríos, M, Jessen, F, Tárraga, L, Nöthen, M M, Maier, W, Boada, M, Ramírez, A

“…To follow-up loci discovered by the International Genomics of Alzheimer’s Disease Project, we attempted independent replication of 19 single nucleotide…”
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New susceptibility locus for hypertension on chromosome 8q by efficient pedigree-breaking in an Italian isolate by Ciullo, Marina, Bellenguez, Céline, Colonna, Vincenza, Nutile, Teresa, Calabria, Antonietta, Pacente, Rosalinda, Iovino, Gianluigi, Trimarco, Bruno, Bourgain, Catherine, Persico, M. Graziella

“…Essential hypertension (EH) affects a large proportion of the adult population in Western countries and is a major risk factor for cardiovascular diseases. EH…”
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