Search Results - "Bellamy, Tomas C"

A Bayesian approach to modelling heterogeneous calcium responses in cell populations by Tilūnaitė, Agne, Croft, Wayne, Russell, Noah, Bellamy, Tomas C, Thul, Rüdiger

“…Calcium responses have been observed as spikes of the whole-cell calcium concentration in numerous cell types and are essential for translating extracellular…”
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Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission by Dobson, Katharine L, Smith, Zoe H, Bellamy, Tomas C

“…At parallel fibre terminals in the cerebellar cortex, glutamate released outside of the active zone can activate AMPA receptors on juxtaposed Bergmann glial…”
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Correction: Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission by Dobson, Katharine L, Smith, Zoe H, Bellamy, Tomas C

“…[This corrects the article DOI: 10.1371/journal.pone.0200937.]…”
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Interactions between Purkinje neurones and Bergmann glia by Bellamy, Tomas C

“…Throughout the development of the cerebellar cortex, Purkinje neurones interact closely with Bergmann glial cells, a specialized form of astrocyte. This review…”
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Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling by Dobson, Katharine L, Jackson, Claire, Balakrishnan, Saju, Bellamy, Tomas C

“…Cerebellar parallel fibres release glutamate at both the synaptic active zone and at extrasynaptic sites-a process known as ectopic release. These sites…”
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Stimulus discrimination in cerebellar Purkinje neurons by Reusch, Katharina, Russell, Noah A, Bellamy, Tomas C

“…Cerebellar Purkinje neurons fire spontaneously in the absence of synaptic input. Overlaid on this intrinsic activity, excitatory input from parallel fibres can…”
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Plasticity of Neuron-Glial Transmission: Equipping Glia for Long-Term Integration of Network Activity by Croft, Wayne, Bellamy, Tomas C., Dobson, Katharine L.

“…The capacity of synaptic networks to express activity-dependent changes in strength and connectivity is essential for learning and memory processes. In recent…”
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Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase by Jackson, Claire, Welch, Heidi C, Bellamy, Tomas C

“…Long-term potentiation (LTP) at the parallel fibre-Purkinje cell synapse in the cerebellum is a recently described and poorly characterized form of synaptic…”
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Differential Sensitivity of Guanylyl Cyclase and Mitochondrial Respiration to Nitric Oxide Measured Using Clamped Concentrations by Bellamy, Tomas C, Griffiths, Charmaine, Garthwaite, John

“…Nitric oxide (NO) signal transduction may involve at least two targets: the guanylyl cyclase-coupled NO receptor (NO GC R), which catalyzes cGMP formation, and…”
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High-throughput analysis of calcium signalling kinetics in astrocytes stimulated with different neurotransmitters by James, Laura R, Andrews, Simon, Walker, Simon, de Sousa, Paula R S, Ray, Aaron, Russell, Noah A, Bellamy, Tomas C

“…Astrocytes express a wide range of receptors for neurotransmitters and hormones that are coupled to increases in intracellular Ca(2+) concentration, enabling…”
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Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum by Dobson, Katharine L., Bellamy, Tomas C.

“…In the cerebellar molecular layer parallel fibre terminals release glutamate from both the active zone and from extrasynaptic “ectopic” sites. Ectopic release…”
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On the Activation of Soluble Guanylyl Cyclase by Nitric Oxide by Bellamy, Tomas C., Wood, John, Garthwaite, John

“…Soluble guanylyl cyclase (sGC) is the major cellular receptor for the intercellular messenger nitric oxide (NO) and mediates a wide range of physiological…”
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Glial Plasticity by Bellamy, Tomas C., Dunaevsky, Anna, Parri, H. Rheinallt

“…Remaining with regulation of intracellular signaling in astrocytes, N. Komin et al. present an analysis of the impact of variation in uptake of calcium into…”
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Rapid Desensitization of the Nitric Oxide Receptor, Soluble Guanylyl Cyclase, Underlies Diversity of Cellular cGMP Responses by Bellamy, T C, Wood, J, Goodwin, D A, Garthwaite, J

“…A major receptor for nitric oxide (NO) is the cGMP-synthesizing enzyme, soluble guanylyl cyclase (sGC), but it is not known how this enzyme behaves in cells…”
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A new and simple method for delivering clamped nitric oxide concentrations in the physiological range: application to activation of guanylyl cyclase-coupled nitric oxide receptors by Griffiths, Charmaine, Wykes, Victoria, Bellamy, Tomas C, Garthwaite, John

“…The signaling molecule nitric oxide (NO) could engage multiple pathways to influence cellular function. Unraveling their relative biological importance has…”
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Ectopic release of glutamate contributes to spillover at parallel fibre synapses in the cerebellum by Balakrishnan, Saju, Dobson, Katharine L., Jackson, Claire, Bellamy, Tomas C.

“…Key points Release of neurotransmitter can sometimes occur outside of the synaptic cleft, a process known as ectopic release. Spillover of the excitatory…”
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N 10 -carbonyl-substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress by Keynes, Robert G, Karchevskaya, Anastasia, Riddall, Dieter, Griffiths, Charmaine H, Bellamy, Tomas C, Chan, A W Edith, Selwood, David L, Garthwaite, John

“…During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified…”
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Probabilistic encoding of stimulus strength in astrocyte global calcium signals by Croft, Wayne, Reusch, Katharina, Tilunaite, Agne, Russell, Noah A., Thul, Rüdiger, Bellamy, Tomas C.

“…Astrocyte calcium signals can range in size from subcellular microdomains to waves that spread through the whole cell (and into connected cells). The…”
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Depression of parallel and climbing fiber transmission to Bergmann glia is input specific and correlates with increased precision of synaptic transmission by Balakrishnan, Saju, Bellamy, Tomas C.

“…In the cerebellar cortex, Bergmann glia enclose the synapses of both parallel and climbing fiber inputs to the Purkinje neuron. The glia express Ca2+‐permeable…”
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N10‐carbonyl‐substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress by Keynes, Robert G., Karchevskaya, Anastasia, Riddall, Dieter, Griffiths, Charmaine H., Bellamy, Tomas C., Chan, A. W. Edith, Selwood, David L., Garthwaite, John

“…During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified…”
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