Search Results - "Bell, Thomas W"

Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation by Vermeire, Kurt, Bell, Thomas W, Van Puyenbroeck, Victor, Giraut, Anne, Noppen, Sam, Liekens, Sandra, Schols, Dominique, Hartmann, Enno, Kalies, Kai-Uwe, Marsh, Mark

“…In eukaryotic cells, surface expression of most type I transmembrane proteins requires translation and simultaneous insertion of the precursor protein into the…”
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Synthesis and Photoisomerization of Substituted Dibenzofulvene Molecular Rotors by Everhart, Stephanie C., Jayasundara, Udaya K., Kim, HyunJong, Procúpez-Schtirbu, Rolando, Stanbery, Wayne A., Mishler, Clay H., Frost, Brian J., Cline, Joseph I., Bell, Thomas W.

“…The synthesis, spectral and structural characterization, and photoisomerization of a family of 2‐substituted dibenzofulvene molecular actuators based on…”
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The signal peptide as a new target for drug design by Lumangtad, Liezel A., Bell, Thomas W.

“…Many current and potential drug targets are membrane-bound or secreted proteins that are expressed and transported via the Sec61 secretory pathway. They are…”
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Comparison of in vitro membrane permeabilities of diverse environmental chemicals with in silico predictions by Intasiri, Amarawan, Illa, Siena E., Prertprawnon, Supadach, Wang, Shenghong, Li, Li, Bell, Thomas W., Li, Dingsheng

“…The parallel artificial membrane permeability assay (PAMPA) is widely used for estimating biomembrane permeabilities of experimental drugs in pharmaceutical…”
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Tsuji–Trost Cyclization of Disulfonamides: Synthesis of 12-Membered, 11-Membered, and Pyridine-Fused Macrocyclic Triamines by Ali, Rameez, Anugu, Sreenivasa, Chawla, Reena, Demillo, Violeta G, Goulinet-Mateo, Florian, Gyawali, Sagar, Hamal, Sunil, Jones, Dylan E, Lamprecht, Katrin, Le, Truc, Lumangtad, Liezel A, Pflug, Nicholas C, Sama, Alekhya, Scarbrough, Emily D, Bell, Thomas W

“…Macrocyclic triamine disulfonamides can be synthesized by double Tsuji–Trost N-allylation reaction of open-chain disulfonamides with…”
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Controlling the Spatial Orientation of Molecular Actuators: Polarized Photoisomerization of 2-Nitro-9-(2,2,2-triphenylethylidene)fluorene in a Thin Polymer Matrix by Ismail, Ali I, Mantha, Jordan H, Kim, Hyun Jong, Bell, Thomas W, Cline, Joseph I

“…The molecule 2-nitro-9-(2,2,2-triphenylethylidene)fluorene (NTEF) was studied as a potential light-driven molecular motor. Absorption at 355 nm causes a…”
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Role of Sec61α2 translocon in insulin biosynthesis by Xu, Xiaoxi, Bell, Thomas W, Le, Truc, Zhao, Ivy, Walker, Emily, Wang, Yiqing, Xu, Ning, Soleimanpour, Scott A, Russ, Holger A, Qi, Ling, Tsai, Billy, Liu, Ming, Arvan, Peter

“…Translocational regulation of proinsulin biosynthesis in pancreatic β-cells is unknown, although several studies have reported an important accessory role for…”
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Human Immunodeficiency Virus Type 1 Escape from Cyclotriazadisulfonamide-Induced CD4-Targeted Entry Inhibition Is Associated with Increased Neutralizing Antibody Susceptibility by VERMEIRE, Kurt, VAN LAETHEM, Kristel, JANSSENS, Wouter, BELL, Thomas W, SCHOLS, Dominique

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds by Lumangtad, Liezel A., Claeys, Elisa, Hamal, Sunil, Intasiri, Amarawan, Basrai, Courtney, Yen-Pon, Expedite, Beenfeldt, Davison, Vermeire, Kurt, Bell, Thomas W.

“…[Display omitted] CADA compounds selectively down-modulate human cell-surface CD4 protein and are of interest as HIV entry inhibitors and as drugs for asthma,…”
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Full Visible Spectrum and White Light Emission with a Single, Input-Tunable Organic Fluorophore by Zavaleta, Andrés, Lykhin, Aleksandr O, Monteiro, Jorge H. S. K, Uchida, Shoto, Bell, Thomas W, de Bettencourt-Dias, Ana, Varganov, Sergey A, Gallucci, Judith

“…The blue emission of M2biQ can be tuned to specific wavelengths throughout the visible region by changing the identity of the cation it interacts with. These…”
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Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II by Smith, Joshua D., Brawley, Jhonnathan, Bordenave, Kate C., Olsen, Ryan K., Intasiri, Amarawan, Cremo, Christine R., Bell, Thomas W.

“…Muscle myosin inhibition could be used to treat many medical conditions involving hypercontractile states, including muscle spasticity, chronic musculoskeletal…”
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Supramolecular optical chemosensors for organic analytes by Bell, Thomas W, Hext, Nicholas M

“…Supramolecular optical chemosensors are abiotic molecular devices that bind analytes by noncovalent interactions, producing a change in light absorption or…”
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Synthesis and Evaluation of 4‑Hydroxycoumarin Imines as Inhibitors of Class II Myosins by Brawley, Jhonnathan, Etter, Emily, Heredia, Dante, Intasiri, Amarawan, Nennecker, Kyle, Smith, Joshua, Welcome, Brandon M, Brizendine, Richard K, Gould, Thomas W, Bell, Thomas W, Cremo, Christine

“…Inhibitors of muscle myosin ATPases are needed to treat conditions that could be improved by promoting muscle relaxation. The lead compound for this study…”
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A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA) by Van Puyenbroeck, Victor, Claeys, Elisa, Schols, Dominique, Bell, Thomas W., Vermeire, Kurt

“…The small molecule CADA was shown to down-modulate the expression of human CD4 in a signal peptide-dependent way through inhibition of its cotranslational…”
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Preprotein signature for full susceptibility to the co‐translational translocation inhibitor cyclotriazadisulfonamide by Van Puyenbroeck, Victor, Pauwels, Eva, Provinciael, Becky, Bell, Thomas W., Schols, Dominique, Kalies, Kai‐Uwe, Hartmann, Enno, Vermeire, Kurt

“…Cyclotriazadisulfonamide (CADA) inhibits the co‐translational translocation of human CD4 (huCD4) into the endoplasmic reticulum lumen in a signal peptide…”
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Reduction of Progranulin-Induced Breast Cancer Stem Cell Propagation by Sortilin-Targeting Cyclotriazadisulfonamide (CADA) Compounds by Berger, Karoline, Pauwels, Eva, Parkinson, Gabrielle, Landberg, Göran, Le, Truc, Demillo, Violeta G, Lumangtad, Liezel A, Jones, Dylan E, Islam, Md Azizul, Olsen, Ryan, Kapri, Topprasad, Intasiri, Amarawan, Vermeire, Kurt, Rhost, Sara, Bell, Thomas W

“…Cyclotriazadisulfonamide (CADA) compounds selectively down-modulate two human proteins of potential therapeutic interest, cluster of differentiation 4 (CD4)…”
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Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies by Chawla, Reena, Van Puyenbroeck, Victor, Pflug, Nicholas C, Sama, Alekhya, Ali, Rameez, Schols, Dominique, Vermeire, Kurt, Bell, Thomas W

“…Cyclotriazadisulfonamide prevents HIV entry into cells by down-modulating surface CD4 receptor expression through binding to the CD4 signal peptide. According…”
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The Anti-HIV potency of cyclotriazadisulfonamide analogs is directly correlated with their ability to down-modulate the CD4 receptor by Vermeire, Kurt, Bell, Thomas W, Choi, Heung-Jin, Jin, Qi, Samala, Meinrado F, Sodoma, Andrej, De Clercq, Erik, Schols, Dominique

“…9-Benzyl-3-methylene-1,5-di-p-toluenesulfonyl-1,5,9-triazacyclododecane (CADA) has been identified as a novel antiviral lead compound with significant…”
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Drugs for Hepatitis C: Unlocking a New Mechanism of Action by Bell, Thomas W.

“…The key to unlocking the secret? The nonstructural protein NS5A has no known enzymatic function, but it is essential for hepatitis C virus (HCV) replication…”
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Circular Dichroism Readout of Sugar Recognition in the Cleft of a Fused-Pyridine Receptor by Tamaru, Shun-ichi, Shinkai, Seiji, Khasanov, Alisher B., Bell, Thomas W.

“…Dicarboxamide host 2 forms 1:1 complexes with n-octyl pyranosides derived from D-glucose, D-mannose, D-galactose, D-fucose, D-lyxose, and D-arabinose…”
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