Search Results - "Bell, Robert M"

Contrast-induced nephropathy following angiography and cardiac interventions by Rear, Roger, Bell, Robert M, Hausenloy, Derek J

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Retrograde heart perfusion: The Langendorff technique of isolated heart perfusion by Bell, Robert M, Mocanu, Mihaela M, Yellon, Derek M

“…Abstract In the late 19th century, a number of investigators were working on perfecting isolated heart model, but it was Oscar Langendorff who, in 1895,…”
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SGLT2 inhibitors: hypotheses on the mechanism of cardiovascular protection by Bell, Robert M, Yellon, Derek M

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SGLT2 Inhibitor, Canagliflozin, Attenuates Myocardial Infarction in the Diabetic and Nondiabetic Heart by Lim, Ven G., MBChB, Bell, Robert M., PhD, Arjun, Sapna, PhD, Kolatsi-Joannou, Maria, PhD, Long, David A., PhD, Yellon, Derek M., PhD, DSc

“…Visual Abstract…”
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The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection—evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology by Davidson, Sean M., Arjun, Sapna, Basalay, Maryna V., Bell, Robert M., Bromage, Daniel I., Bøtker, Hans Erik, Carr, Richard D., Cunningham, John, Ghosh, Arjun K., Heusch, Gerd, Ibanez, Borja, Kleinbongard, Petra, Lecour, Sandrine, Maddock, Helen, Ovize, Michel, Walker, Malcolm, Wiart, Marlene, Yellon, Derek M.

“…Due to its poor capacity for regeneration, the heart is particularly sensitive to the loss of contractile cardiomyocytes. The onslaught of damage caused by…”
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Targeting reperfusion injury in acute myocardial infarction: a review of reperfusion injury pharmacotherapy by Sharma, Vikram, Bell, Robert M, Yellon, Derek M

“…Acute myocardial infarction (AMI) (secondary to lethal ischemia-reperfusion [IR]) contributes to much of the mortality and morbidity from ischemic heart…”
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Do too many cooks spoil the broth? Using the number of developers to enhance defect prediction models by Weyuker, Elaine J., Ostrand, Thomas J., Bell, Robert M.

“…Fault prediction by negative binomial regression models is shown to be effective for four large production software systems from industry. A model developed…”
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Comparing the effectiveness of several modeling methods for fault prediction by Weyuker, Elaine J., Ostrand, Thomas J., Bell, Robert M.

“…We compare the effectiveness of four modeling methods—negative binomial regression, recursive partitioning, random forests and Bayesian additive regression…”
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SGLT2 inhibitors reduce infarct size in reperfused ischemic heart and improve cardiac function during ischemic episodes in preclinical models by Andreadou, Ioanna, Bell, Robert M., Bøtker, Hans Erik, Zuurbier, Coert J.

“…The sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of effective drugs managing patients, who suffer from type 2 diabetes (T2D): Landmark…”
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Remote ischaemic conditioning and ischaemic heart disease by Bell, Robert M

“…As clinical evidence builds regarding the efficacy of remote ischaemic conditioning's ability to attenuate myocardial injury arising from acute coronary…”
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SGLT2 inhibitors: reviving the sodium-hydrogen exchanger cardioprotection hypothesis? by Arjun, Sapna, Bell, Robert M

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Pivotal role of NOX-2-containing NADPH oxidase in early ischemic preconditioning by Bell, Robert M, Cave, Alison C, Johar, Sofian, Hearse, David J, Shah, Ajay M, Shattock, Michael J

“…ABSTRACTReactive oxygen species (ROS)‐mediated signaling is implicated in early ischemic preconditioning (PC). A NOX‐2‐containing NADPH oxidase is a recognized…”
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SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart by Almalki, Alhanoof, Arjun, Sapna, Harding, Idris, Jasem, Hussain, Kolatsi-Joannou, Maria, Jafree, Daniyal J., Pomeranz, Gideon, Long, David A., Yellon, Derek M., Bell, Robert M.

“…Hyperglycaemia is common during acute coronary syndromes (ACS) irrespective of diabetic status and portends excess infarct size and mortality, but the…”
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Characterization of the Langendorff Perfused Isolated Mouse Heart Model of Global Ischemia-Reperfusion Injury: Impact of Ischemia and Reperfusion Length on Infarct Size and LDH Release by Rossello, Xavier, Hall, Andrew R, Bell, Robert M, Yellon, Derek M

“…The Langendorff perfused isolated mouse heart model is commonly used to assess the efficacy of cardioprotective therapies, although the duration of ischemia…”
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Conditioning the whole heart—not just the cardiomyocyte by Bell, Robert M, Yellon, Derek M

“…Abstract Conditioning, the recruitment of endogenous cytoprotective pathways that protect the myocardium against injurious ischaemia/reperfusion injury, has…”
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Implications of Kidney Disease in the Cardiac Patient by Rear, Roger, BSc, MRCP, Meier, Pascal, MD, Bell, Robert M., BSc, PhD, MRCP

“…Traditional cardiovascular risk factors, particularly hypertension and diabetes, are common in the disease processes of both renal and cardiac pathology…”
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Remote Ischaemic Conditioning in Carotid Artery Stenting: Another Step on the Journey Toward Clinical Translatability? by Bell, Robert M, Yellon, Derek M

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Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway by BELL, Robert M, YELLON, Derek M

“…The purpose of this study was to determine whether atorvastatin, a 3-hydroxy-3-methylglutaryl (HMG)-co-enzyme A (CoA) reductase inhibitor, limits myocardial…”
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Predicting the location and number of faults in large software systems by Ostrand, T.J., Weyuker, E.J., Bell, R.M.

“…Advance knowledge of which files in the next release of a large software system are most likely to contain the largest numbers of faults can be a very valuable…”
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Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation by Hannun, Yusuf A., Bell, Robert M.

“…The discovery that breakdown products of cellular sphin-golipids are biologically active has generated interest in the role of these molecules in cell…”
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