Search Results - "Bell, Robert J.A."

DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors by Mazor, Tali, Pankov, Aleksandr, Johnson, Brett E., Hong, Chibo, Hamilton, Emily G., Bell, Robert J.A., Smirnov, Ivan V., Reis, Gerald F., Phillips, Joanna J., Barnes, Michael J., Idbaih, Ahmed, Alentorn, Agusti, Kloezeman, Jenneke J., Lamfers, Martine L.M., Bollen, Andrew W., Taylor, Barry S., Molinaro, Annette M., Olshen, Adam B., Chang, Susan M., Song, Jun S., Costello, Joseph F.

“…The evolutionary history of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast to stable genetic events, epigenetic…”
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Understanding TERT Promoter Mutations: A Common Path to Immortality by Bell, Robert J A, Rube, H Tomas, Xavier-Magalhães, Ana, Costa, Bruno M, Mancini, Andrew, Song, Jun S, Costello, Joseph F

“…Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining telomere length, telomerase relieves a main barrier on cellular lifespan,…”
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Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner by Mancini, Andrew, Xavier-Magalhães, Ana, Woods, Wendy S., Nguyen, Kien-Thiet, Amen, Alexandra M., Hayes, Josie L., Fellmann, Christof, Gapinske, Michael, McKinney, Andrew M., Hong, Chibo, Jones, Lindsey E., Walsh, Kyle M., Bell, Robert J.A., Doudna, Jennifer A., Costa, Bruno M., Song, Jun S., Perez-Pinera, Pablo, Costello, Joseph F.

“…TERT promoter mutations reactivate telomerase, allowing for indefinite telomere maintenance and enabling cellular immortalization. These mutations specifically…”
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Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process by Ohba, Shigeo, Mukherjee, Joydeep, Johannessen, Tor-Christian, Mancini, Andrew, Chow, Tracy T, Wood, Matthew, Jones, Lindsey, Mazor, Tali, Marshall, Roxanne E, Viswanath, Pavithra, Walsh, Kyle M, Perry, Arie, Bell, Robert J A, Phillips, Joanna J, Costello, Joseph F, Ronen, Sabrina M, Pieper, Russell O

“…Mutations in the isocitrate dehydrogenase gene IDH1 are common in low-grade glioma, where they result in the production of 2-hydroxyglutarate (2HG), disrupted…”
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Intermediate DNA methylation is a conserved signature of genome regulation by Elliott, GiNell, Hong, Chibo, Xing, Xiaoyun, Zhou, Xin, Li, Daofeng, Coarfa, Cristian, Bell, Robert J.A., Maire, Cecile L., Ligon, Keith L., Sigaroudinia, Mahvash, Gascard, Philippe, Tlsty, Thea D., Harris, R. Alan, Schalkwyk, Leonard C., Bilenky, Misha, Mill, Jonathan, Farnham, Peggy J., Kellis, Manolis, Marra, Marco A., Milosavljevic, Aleksandar, Hirst, Martin, Stormo, Gary D., Wang, Ting, Costello, Joseph F.

“…The role of intermediate methylation states in DNA is unclear. Here, to comprehensively identify regions of intermediate methylation and their quantitative…”
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YY1 regulates melanocyte development and function by cooperating with MITF by Li, Juying, Song, Jun S, Bell, Robert J A, Tran, Thanh-Nga T, Haq, Rizwan, Liu, Huifei, Love, Kevin T, Langer, Robert, Anderson, Daniel G, Larue, Lionel, Fisher, David E

“…Studies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1…”
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Systematic dissection of coding exons at single nucleotide resolution supports an additional role in cell-specific transcriptional regulation by Birnbaum, Ramon Y, Patwardhan, Rupali P, Kim, Mee J, Findlay, Gregory M, Martin, Beth, Zhao, Jingjing, Bell, Robert J A, Smith, Robin P, Ku, Angel A, Shendure, Jay, Ahituv, Nadav

“…In addition to their protein coding function, exons can also serve as transcriptional enhancers. Mutations in these exonic-enhancers (eExons) could alter both…”
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The genetics of splicing in neuroblastoma by Chen, Justin, Hackett, Christopher S, Zhang, Shile, Song, Young K, Bell, Robert J A, Molinaro, Annette M, Quigley, David A, Balmain, Allan, Song, Jun S, Costello, Joseph F, Gustafson, W Clay, Van Dyke, Terry, Kwok, Pui-Yan, Khan, Javed, Weiss, William A

“…Regulation of mRNA splicing, a critical and tightly regulated cellular function, underlies the majority of proteomic diversity and is frequently disrupted in…”
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Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution by Kircher, Martin, Xiong, Chenling, Martin, Beth, Schubach, Max, Inoue, Fumitaka, Bell, Robert J. A., Costello, Joseph F., Shendure, Jay, Ahituv, Nadav

“…The majority of common variants associated with common diseases, as well as an unknown proportion of causal mutations for rare diseases, fall in noncoding…”
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The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer by Bell, Robert J. A., Rube, H. Tomas, Kreig, Alex, Mancini, Andrew, Fouse, Shaun D., Nagarajan, Raman P., Choi, Serah, Hong, Chibo, He, Daniel, Pekmezci, Melike, Wiencke, John K., Wrensch, Margaret R., Chang, Susan M., Walsh, Kyle M., Myong, Sua, Song, Jun S., Costello, Joseph F.

“…Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, which are fundamental…”
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Recurrent epimutations activate gene body promoters in primary glioblastoma by Nagarajan, Raman P, Zhang, Bo, Bell, Robert J A, Johnson, Brett E, Olshen, Adam B, Sundaram, Vasavi, Li, Daofeng, Graham, Ashley E, Diaz, Aaron, Fouse, Shaun D, Smirnov, Ivan, Song, Jun, Paris, Pamela L, Wang, Ting, Costello, Joseph F

“…Aberrant DNA hypomethylation may play an important role in the growth rate of glioblastoma (GBM), but the functional impact on transcription remains poorly…”
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An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element by Clop, Alex, Bertoni, Anna, Spain, Sarah L, Simpson, Michael A, Pullabhatla, Venu, Tonda, Raul, Hundhausen, Christian, Di Meglio, Paola, De Jong, Pieter, Hayday, Adrian C, Nestle, Frank O, Barker, Jonathan N, Bell, Robert J A, Capon, Francesca, Trembath, Richard C

“…Psoriasis is an immune-mediated skin disorder that is inherited as a complex genetic trait. Although genome-wide association scans (GWAS) have identified 36…”
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Abstract B12: GABP selectively binds and activates the mutant TERT promoter across multiple cancer types by Bell, Robert J.A, Rube, H. Tomas, Kreig, Alex, Mancini, Andrew, Fouse, Shaun F., Nagarajan, Raman P., Choi, Serah, Hong, Chibo, He, Daniel, Pekmezci, Melike, Wiencke, John K., Wrensch, Margaret R., Chang, Susan M., Walsh, Kyle M., Myong, Sua, Song, Jun S., Costello, Joseph F.

“…Abstract Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, fundamental…”
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A mathematical model for the determination of steady-state cardiolipin remodeling mechanisms using lipidomic data by Zhang, Lu, Bell, Robert J A, Kiebish, Michael A, Seyfried, Thomas N, Han, Xianlin, Gross, Richard W, Chuang, Jeffrey H

“…Technical advances in lipidomic analysis have generated tremendous amounts of quantitative lipid molecular species data, whose value has not been fully…”
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EG-07CELL CYCLE SIGNATURE AND TUMOR PHYLOGENY ARE ENCODED IN THE EVOLUTIONARY DYNAMICS OF DNA METHYLATION IN GLIOMA by Mazor, Tali, Pankov, Aleksandr, Johnson, Brett E., Hong, Chibo, Bell, Robert J.A., Smirnov, Ivan V., Reis, Gerald F., Phillips, Joanna J., Barnes, Michael, Bollen, Andrew W., Taylor, Barry S., Molinaro, Annette M., Olshen, Adam B., Song, Jun S., Berger, Mitchel S., Chang, Susan M., Costello, Joseph F.

“…The clonal evolution of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast, tumor epigenetic states, including DNA…”
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Methods for cancer epigenome analysis by Nagarajan, Raman P, Fouse, Shaun D, Bell, Robert J A, Costello, Joseph F

“…Accurate detection of epimutations in tumor cells is crucial for -understanding the molecular pathogenesis of cancer. Alterations in DNA methylation in cancer…”
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CLONAL EVOLUTION OF GLIOMAS IS ENCODED IN THE EVOLUTIONARY DYNAMICS OF DNA METHYLATION by Costello, J. F., Mazor, T., Pankov, A., Johnson, B. E., Hong, C., Bell, R. J. A., Smirnov, I. V., Reis, G. F., Phillips, J. J., Barnes, M., Bollen, A. W., Taylor, B. S., Molinaro, A. M., Olshen, A. B., Song, J. S., Berger, M. S., Chang, S. M.

“…BACKGROUND: The clonal evolution of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast, tumor epigenetic states are…”
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