Search Results - "Bell, Peter A"

No Substrate Left behind—Mining of Shotgun Proteomics Datasets Rescues Evidence of Proteolysis by SARS-CoV-2 3CLpro Main Protease by Bell, Peter A., Overall, Christopher M.

“…Proteolytic processing is the most ubiquitous post-translational modification and regulator of protein function. To identify protease substrates, and hence the…”
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Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase by Jobin, Parker G., Solis, Nestor, Machado, Yoan, Bell, Peter A., Kwon, Nam Hoon, Kim, Sunghoon, Overall, Christopher M., Butler, Georgina S.

“…Tryptophanyl-tRNA synthetase (WRS) is a cytosolic aminoacyl-tRNA synthetase essential for protein synthesis. WRS is also one of a growing number of…”
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Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage by Jobin, Parker G., Solis, Nestor, Machado, Yoan, Bell, Peter A., Rai, Simran K., Kwon, Nam Hoon, Kim, Sunghoon, Overall, Christopher M., Butler, Georgina S.

“…Tyrosyl-tRNA synthetase ligates tyrosine to its cognate tRNA in the cytoplasm, but it can also be secreted through a noncanonical pathway. We found that…”
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Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases by Hartley, Claire L, Edwards, Sarah, Mullan, Lorna, Bell, Peter A, Fresquet, Maryline, Boot-Handford, Raymond P, Briggs, Michael D

“…Mutant matrilin-3 (V194D) forms non-native disulphide bonded aggregates in the rER of chondrocytes from cell and mouse models of multiple epiphyseal dysplasia…”
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Genotype to phenotype correlations in cartilage oligomeric matrix protein associated chondrodysplasias by Briggs, Michael D, Brock, Joanne, Ramsden, Simon C, Bell, Peter A

“…Pseudoachondroplasia (PSACH) and autosomal dominant multiple epiphyseal dysplasia (MED) are chondrodysplasias resulting in short-limbed dwarfism, joint pain…”
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Development of an Undergraduate Course in Chemical Laboratory Safety through an Academic/Industrial Collaboration by Huston, Ericka M, Milligan, John A, Powell, Jaclyn R, Smith, Ashley M, Neal, David, Duval, Keith M, DiNardo, Mark A, Stoddard, Charles, Bell, Peter A, Berning, Aric W, Wipf, Peter, Bandik, George C

“…A 14 week undergraduate course on laboratory safety was developed at the University of Pittsburgh. The first segment of the course consists of a series of…”
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Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia by Piróg, Katarzyna A, Irman, Andreja, Young, Siobhan, Halai, Poonam, Bell, Peter A, Boot-Handford, Raymond P, Briggs, Michael D

“…Pseudoachondroplasia (PSACH) is an autosomal dominant skeletal dysplasia caused by mutations in cartilage oligomeric matrix protein (COMP) and characterised by…”
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Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates by Bell, Peter A., Scheuermann, Sophia, Renner, Florian, Pan, Christina L., Lu, Henry Y., Turvey, Stuart E., Bornancin, Frédéric, Régnier, Catherine H., Overall, Christopher M.

“…[Display omitted] We developed a bioinformatics-led substrate discovery workflow to expand the known substrate repertoire of MALT1. Our approach, termed…”
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An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia by Nundlall, Seema, Rajpar, M. Helen, Bell, Peter A., Clowes, Christopher, Zeeff, Leo A. H., Gardner, Benjamin, Thornton, David J., Boot-Handford, Raymond P., Briggs, Michael D.

“…Multiple epiphyseal dysplasia (MED) can result from mutations in matrilin-3, a structural protein of the cartilage extracellular matrix. We have previously…”
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A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth by Gualeni, Benedetta, Rajpar, M Helen, Kellogg, Aaron, Bell, Peter A, Arvan, Peter, Boot-Handford, Raymond P, Briggs, Michael D

“…Disease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal…”
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No Substrate Left behind—Mining of Shotgun Proteomics Datasets Rescues Evidence of Proteolysis by SARS-CoV-2 3CL[sup.pro] Main Protease by Bell, Peter A, Overall, Christopher M

“…Proteolytic processing is the most ubiquitous post-translational modification and regulator of protein function. To identify protease substrates, and hence the…”
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SNPstream® UHT: Ultra-High Throughput SNP Genotyping for Pharmacogenomics and Drug Discovery by Peter A. Bell, Surendra Chaturvedi, Craig A. Gelfand, Ching Yu Huang, Michael Kochersperger, Rafael Kopla, Frank Modica, Mark Pohl, Shobha Varde, Renbin Zhao, Xiaojian Zhao, Michael T. Boyce-Jacino

“…Single nucleotide polymorphism (SNP) genotyping is playing an increasing role in genome mapping, pharmacogenetic studies, and drug discovery. To date,…”
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Proteomic and N‑Terminomic TAILS Analyses of Human Alveolar Bone Proteins: Improved Protein Extraction Methodology and LysargiNase Digestion Strategies Increase Proteome Coverage and Missing Protein Identification by Bell, Peter A, Solis, Nestor, Kizhakkedathu, Jayachandran N, Matthew, Ian, Overall, Christopher M

“…With 2129 proteins still classified by the Human Proteome Organisation Human Proteome Project (HPP) as “missing” without compelling evidence of protein…”
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Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CL pro main protease (Mpro) from proteomic identification of P6-P6' active site specificity by Cesar Ramos de Jesus, Hugo, Solis, Nestor, Machado, Yoan, Pablos, Isabel, Bell, Peter A, Kappelhoff, Reinhild, Grin, Peter M, Sorgi, Carlos A, Butler, Georgina S, Overall, Christopher M

“…SARS-CoV-2 3C-like main protease (3CL ) is essential for protein excision from the viral polyprotein. 3CL inhibitor drug development to block SARS-CoV-2…”
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Mechanistic understanding of the combined immunodeficiency in complete human CARD11 deficiency by Lu, Henry Y., Sharma, Mehul, Sharma, Ashish A., Lacson, Atilano, Szpurko, Ashley, Luider, Joanne, Dharmani-Khan, Poonam, Shameli, Afshin, Bell, Peter A., Guilcher, Gregory M.T., Lewis, Victor A., Vasquez, Marta Rojas, Desai, Sunil, McGonigle, Lyle, Murguia-Favela, Luis, Wright, Nicola A.M., Sergi, Consolato, Wine, Eytan, Overall, Christopher M., Suresh, Sneha, Turvey, Stuart E.

“…Germline pathogenic variants impairing the caspase recruitment domain family member 11 (CARD11)–B cell chronic lymphocytic leukemia/lymphoma 10 (BCL10)–MALT1…”
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Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures by Bell, Peter A, Wagener, Raimund, Zaucke, Frank, Koch, Manuel, Selley, Julian, Warwood, Stacey, Knight, David, Boot-Handford, Raymond P, Thornton, David J, Briggs, Michael D

“…Pseudoachondroplasia and multiple epiphyseal dysplasia are genetic skeletal diseases resulting from mutations in cartilage structural proteins. Electron…”
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What Do We Really Know About Neurological Misdiagnosis in the Emergency Department? by Wachtler, Janice, BA, Bell, Peter A., DO, FACOEP, Brabson, Thomas, DO, FACOEP

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The utility of mouse models to provide information regarding the pathomolecular mechanisms in human genetic skeletal diseases: The emerging role of endoplasmic reticulum stress (Review) by BRIGGS, MICHAEL D, BELL, PETER A, PIROG, KATARZYNA A

“…Genetic skeletal diseases (GSDs) are an extremely diverse and complex group of rare genetic diseases that primarily affect the development and homeostasis of…”
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Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome by Pablos, Isabel, Machado, Yoan, de Jesus, Hugo C. Ramos, Mohamud, Yasir, Kappelhoff, Reinhild, Lindskog, Cecilia, Vlok, Marli, Bell, Peter A., Butler, Georgina S., Grin, Peter M., Cao, Quynh T., Nguyen, Jenny P., Solis, Nestor, Abbina, Srinivas, Rut, Wioletta, Vederas, John C., Szekely, Laszlo, Szakos, Attila, Drag, Marcin, Kizhakkedathu, Jayachandran N., Mossman, Karen, Hirota, Jeremy A., Jan, Eric, Luo, Honglin, Banerjee, Arinjay, Overall, Christopher M.

“…The main viral protease (3CLpro) is indispensable for SARS-CoV-2 replication. We delineate the human protein substrate landscape of 3CLpro by TAILS…”
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Quantitation of proteins using a dye–metal-based colorimetric protein assay by Antharavally, Babu S., Mallia, Krishna A., Rangaraj, Priya, Haney, Paul, Bell, Peter A.

“…We describe a dye–metal (polyhydroxybenzenesulfonephthalein-type dye and a transition metal) complex-based total protein determination method. The binding of…”
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