Search Results - "Bell, Noah"

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice by Finn, Patricia D, Rodriguez, David, Kohler, Jill, Jiang, Zhengfeng, Wan, Sindy, Blanco, Erick, King, Andrew J, Chen, Tao, Bell, Noah, Dragoli, Dean, Jacobs, Jeffrey W, Jain, Rakesh, Leadbetter, Michael, Siegel, Matthew, Carreras, Christopher W, Koo-McCoy, Samantha, Shaw, Karen, Le, Cathy, Vanegas, Sandra, Hsu, I-Hsin, Kozuka, Kenji, Okamoto, Keiko, Caldwell, Jeremy S, Lewis, Jason G

“…Takeda G protein-coupled receptor 5 (TGR5) agonists induce systemic release of glucagon-like peptides (GLPs) from intestinal L cells, a potentially therapeutic…”
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Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans by Spencer, Andrew G, Labonte, Eric D, Rosenbaum, David P, Plato, Craig F, Carreras, Christopher W, Leadbetter, Michael R, Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Bell, Noah, Tabora, Jocelyn, Joly, Kristin M, Navre, Marc, Jacobs, Jeffrey W, Charmot, Dominique

“…The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an…”
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Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD by Labonté, Eric D., Carreras, Christopher W., Leadbetter, Michael R., Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Dy, Edward, Black, Deborah, Zhong, Ziyang, Langsetmo, Ingrid, Spencer, Andrew G., Bell, Noah, Deshpande, Desiree, Navre, Marc, Lewis, Jason G., Jacobs, Jeffrey W., Charmot, Dominique

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MODL-48. AUTOMATING ANALYSIS OF ORGANOTYPIC BRAIN SLICE CULTURE USING MACHINE LEARNING-POWERED COMPUTER VISION by Bell, Noah, Buckley, Andrew, Mann, Breanna, Adefolaju, Adebimpe, Dasari, Rajaneekar, Hingtgen, Shawn, Satterlee, Andrew B

“…Abstract The difficulty of image labeling and analysis poses a problem for many areas of scientific research, including the recently developed Organotypic…”
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MODL-13. ORGANOTYPIC BRAIN SLICE CULTURE PLATFORM AS A MODEL OF PEDIATRIC LOW GRADE GLIOMAS by Mann, Breanna, Artz, Nichole, Adefolaju, Adebimpe, Dasari, Rajaneekar, Bell, Noah, Buckley, Andrew, Kram, David, Hingtgen, Shawn, Satterlee, Andrew

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MODL-41. ORGANOTYPIC BRAIN SLICE CULTURE PLATFORM AS A NOVEL PRE-CLINICAL MODEL FOR PATIENT DERIVED CELL LINES by Mann, Breanna, Zhang, Xiaopei, Bell, Noah, Adefolaju, Adebimpe, Dasari, Rajaneekar, Hingtgen, Shawn, Satterlee, Andrew

“…Abstract The lack of experimentally tractable models that recapitulate brain structure and function represents a major impediment in the development of novel…”
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TMOD-31. AN ORGANOTYPIC TISSUE PLATFORM TO BRIDGE IN VITRO AND IN VIVO ASSAYS FOR BRAIN CANCER TREATMENT by Mann, Breanna, Bell, Noah, Dunn, Denise, Floyd, Scott, Hingtgen, Shawn, Satterlee, Andrew

“…Abstract Brain cancers remain one of the greatest medical challenges. The lack of experimentally tractable models that recapitulate brain structure/function…”
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MODL-27. An organotypic brain slice culture platform as a novel pre-clinical model for diffuse intrinsic pontine glioma and diffuse midline glioma by Mann, Breanna, Zhang, Xiaopei, Bell, Noah, Adefolaju, Adebimpe, Dasari, Rajaneekar, Valdivia, Alain, Buckley, Andrew, Quinsey, Carolyn, Hingtgen, Shawn, Satterlee, Andrew

“…Abstract High-grade pediatric brain tumors (PBTs) such as diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG) are devastating diseases…”
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Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD by Labonté, Eric D, Carreras, Christopher W, Leadbetter, Michael R, Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Dy, Edward, Black, Deborah, Zhong, Ziyang, Langsetmo, Ingrid, Spencer, Andrew G, Bell, Noah, Deshpande, Desiree, Navre, Marc, Lewis, Jason G, Jacobs, Jeffrey W, Charmot, Dominique

“…In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic cascade leading to hyperthyroidism, metabolic bone disease,…”
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EXTH-01. SECOND GENERATION OF INDUCED NEURAL STEM CELLS TO MIGRATE AND KILL AS AN ADJUVANT TO RADIOTHERAPY IN NON-SMALL CELL LUNG CANCER METASTASIS by Mercer-Smith, Alison, Thang, Morrent, Buckley, Andrew, Valdivia, Alain, Jiang, Wulin, Bell, Noah, Kumar, Rashmi, Bomba, Hunter, Woodell, Alex, Luo, Daniel, Floyd, Scott, Hingtgen, Shawn

“…Abstract Non-small cell lung cancer (NSCLC) spread to the leptomeninges is devastating with a median survival of only a few months. Radiation is frequently…”
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Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5) by Chen, Tao, Reich, Nicholas William, Bell, Noah, Finn, Patricia D, Rodriguez, David, Kohler, Jill, Kozuka, Kenji, He, Limin, Spencer, Andrew G, Charmot, Dominique, Navre, Marc, Carreras, Christopher W, Koo-McCoy, Samantha, Tabora, Jocelyn, Caldwell, Jeremy S, Jacobs, Jeffrey W, Lewis, Jason Gustaf

“…Bile acid signaling and metabolism in the gastrointestinal tract have wide-ranging influences on systemic disease. G protein-coupled bile acid receptor 1…”
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CNSC-39. GENERATION AND CHARACTERIZATION OF LIVING ORGANOTYPIC BRAIN SLICE CULTURES AS A NOVEL PRE-CLINICAL MODEL FOR BRAIN CANCER by Dasari, Rajaneekar, Mann, Breanna, Zhang, Xiaopei, Bell, Noah, Adefolaju, Adebimpe, Thang, Morrent, Kanchi, Krishna, Valdivia, Alain, Yang, Yang, Buckley, Andrew, Lettry, Vivien, Quinsey, Carolyn, Rauf, Yasmeen, Kram, David, Cassidy, Noah, Vaziri, Cyrus, Corcoran, David L, Rego, Stephen, Jiang, Yuchao, Graves, Lee M, Dunn, Denise, Floyd, Scott, Baldwin, Albert, Hingtgen, Shawn, Satterlee, Andrew B

“…Abstract A challenge in cancer research is developing reproducible, reliable, and practical models which can capture the complexity of cancer development and…”
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MODL-44. DEVELOPMENT OF A NOVEL, PERSONALIZED DRUG SENSITIVITY SCORE TO ASSESS TUMOR KILLING AND TOXICITY WITHIN AN ORGANOTYPIC BRAIN SLICE CULTURE PLATFORM by Mann, Breanna, Zhang, Xiaopei, Bell, Noah, Adefolaju, Adebimpe, Thang, Morrent, Dasari, Rajaneekar, Kanchi, Krishna, Valdivia, Alain, Yang, Yang, Buckley, Andrew, Lettry, Vivien, Quinsey, Carolyn, Rauf, Yasmeen, Kram, David, Cassidy, Noah, Vaziri, Cyrus, Corcoran, David L, Rego, Stephen, Jiang, Yuchao, Graves, Lee M, Dunn, Denise, Floyd, Scott, Baldwin, Albert, Hingtgen, Shawn, Satterlee, Andrew B

“…Abstract Development of new therapeutics for clinical use requires balancing tumor killing and off-target toxicity to normal tissue. We have established an…”
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MODL-28. LIVING EX VIVO ORGANOTYPIC BRAIN SLICE CULTURES AS A COMPREHENSIVE SUBSTRATE FOR TUMOR ENGRAFTMENT AND ANALYSIS by Adefolaju, Adebimpe, Mann, Breanna, Zhang, Xiaopei, Bell, Noah, Thang, Morrent, Dasari, Rajaneekar, Kanchi, Krishna, Valdivia, Alain, Yang, Yang, Buckley, Andrew, Lettry, Vivien, Quinsey, Carolyn, Rauf, Yasmeen, Kram, David, Cassidy, Noah, Vaziri, Cyrus, Corcoran, David L, Rego, Stephen, Jiang, Yuchao, Graves, Lee M, Dunn, Denise, Floyd, Scott, Baldwin, Albert, Hingtgen, Shawn, Satterlee, Andrew B

“…Abstract Heterogeneity, drug resistance, tumor infiltration, and invasiveness significantly contribute to the poor prognosis often associated with brain…”
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MODL-03. AN EX VIVO PLATFORM BASED ON ORGANOTYPIC BRAIN SLICE CULTURE FOR INFORMING PERSONALIZED BRAIN CANCER THERAPY by Zhang, Xiaopei, Mann, Breanna, Bell, Noah, Adefolaju, Adebimpe, Thang, Morrent, Dasari, Rajaneekar, Kanchi, Krishna, Valdivia, Alain, Yang, Yang, Buckley, Andrew, Lettry, Vivien, Quinsey, Carolyn, Rauf, Yasmeen, Kram, David, Cassidy, Noah, Vaziri, Cyrus, Corcoran, David L, Rego, Stephen, Jiang, Yuchao, Graves, Lee M, Dunn, Denise, Floyd, Scott, Baldwin, Albert, Hingtgen, Shawn, Satterlee, Andrew B

“…Abstract While the improved classification of CNS tumors is already enhancing the scientific rigor of clinical brain cancer treatment guidelines, the impact of…”
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OTHR-05. A LIVING EX VIVO PLATFORM FOR FUNCTIONAL, PERSONALIZED PEDIATRIC BRAIN CANCER DIAGNOSIS by Mann, Breanna, Zhang, Xiaopei, Bell, Noah, Adefolaju, Adebimpe, Thang, Morrent, Dasari, Rajaneekar, Kanchi, Krishna, Valdivia, Alain, Yang, Yang, Quinsey, Carolyn, Rauf, Yasmeen, Kram, David, Cassidy, Noah, Viziri, Cyrus, Corcoran, David L, Rego, Stephan, Jiang, Yuchao, Graves, Lee M, Dunn, Denise, Floyd, Scott, Baldwin, Albert, Hingtgen, Shawn, Satterlee, Andrew

“…Abstract Functional precision medicine platforms are emerging as promising strategies to improve pre-clinical drug testing and guide clinical decisions. We…”
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MMAP-04 CYTOTOXIC, TUMOR-HOMING INDUCED NEURAL STEM CELLS AS AN ADJUVANT TO RADIATION IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER LEPTOMENINGEAL METASTASES by Mercer-Smith, Alison, Jiang, Wulin, Valdivia, Alain, Bell, Noah, Woodell, Alex, Floyd, Scott, Hingtgen, Shawn

“…Abstract INTRODUCTION Non-small cell lung cancer (NSCLC) is the most common cancer to spread to the brain, and spread to the leptomeninges is particularly…”
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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens by Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Marcotte, Douglas, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Otipoby, Kevin L., Poreci, Urjana, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min

“…[Display omitted] Since the approval of ibrutinib for the treatment of B-cell malignancies in 2012, numerous clinical trials have been reported using covalent…”
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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors by Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Gua, Chuck, Liu, Ying, Liu, YuTing, Lulla, Mukush, Marcotte, Douglas, Marx, Isaac, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min

“…[Display omitted] Bruton’s tyrosine kinase (BTK) is an essential node on the BCR signaling in B cells, which are clinically validated to play a critical role…”
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Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3 by Jacobs, Jeffrey W., Leadbetter, Michael R., Bell, Noah, Koo-McCoy, Samantha, Carreras, Christopher W., He, Limin, Kohler, Jill, Kozuka, Kenji, Labonté, Eric D., Navre, Marc, Spencer, Andrew G., Charmot, Dominique

“…We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na+/H+ exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in…”
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