Search Results - "Bell, Nicholas A. W."

Specific Protein Detection Using Designed DNA Carriers and Nanopores by Bell, Nicholas A. W, Keyser, Ulrich F

“…Nanopores are a versatile technique for the detection and characterization of single molecules in solution. An ongoing challenge in the field is to find…”
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Quantifying Nanomolar Protein Concentrations Using Designed DNA Carriers and Solid-State Nanopores by Kong, Jinglin, Bell, Nicholas A. W, Keyser, Ulrich F

“…Designed “DNA carriers” have been proposed as a new method for nanopore based specific protein detection. In this system, target protein molecules bind to a…”
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Microfluidic flow-cell with passive flow control for microscopy applications by Bell, Nicholas A W, Molloy, Justin E

“…We present a fast, inexpensive and robust technique for constructing thin, optically transparent flow-cells with pump-free flow control. Using layers of glass,…”
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Single Protein Molecule Detection by Glass Nanopores by Li, Wenhong, Bell, Nicholas A. W, Hernández-Ainsa, Silvia, Thacker, Vivek V, Thackray, Alana M, Bujdoso, Raymond, Keyser, Ulrich F

“…Nanopores can be used to detect and analyze single molecules in solution. We have used glass nanopores made by laser-assisted capillary-pulling, as a…”
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DNA Origami Nanopores by Bell, Nicholas A. W, Engst, Christian. R, Ablay, Marc, Divitini, Giorgio, Ducati, Caterina, Liedl, Tim, Keyser, Ulrich F

“…We demonstrate the assembly of functional hybrid nanopores for single molecule sensing by inserting DNA origami structures into solid-state nanopores. In our…”
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DNA Origami Nanopores for Controlling DNA Translocation by Hernández-Ainsa, Silvia, Bell, Nicholas A. W, Thacker, Vivek V, Göpfrich, Kerstin, Misiunas, Karolis, Fuentes-Perez, Maria Eugenia, Moreno-Herrero, Fernando, Keyser, Ulrich F

“…We combine DNA origami structures with glass nanocapillaries to reversibly form hybrid DNA origami nanopores. Trapping of the DNA origami onto the…”
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Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores by Bell, Nicholas A. W., Keyser, Ulrich F.

“…The simultaneous detection of a large number of different analytes is important in bionanotechnology research and in diagnostic applications. Nanopore sensing…”
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Studying DNA translocation in nanocapillaries using single molecule fluorescence by Thacker, Vivek V, Ghosal, Sandip, Hernández-Ainsa, Silvia, Bell, Nicholas A W, Keyser, Ulrich F

“…We demonstrate simultaneous measurements of DNA translocation into glass nanopores using ionic current detection and fluorescent imaging. We verify the…”
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Nanotubes Complexed with DNA and Proteins for Resistive-Pulse Sensing by Sha, Jingjie, Hasan, Tawfique, Milana, Silvia, Bertulli, Cristina, Bell, Nicholas A. W, Privitera, Giulia, Ni, Zhonghua, Chen, Yunfei, Bonaccorso, Francesco, Ferrari, Andrea C, Keyser, Ulrich F, Huang, Yan Yan S

“…We use a resistive-pulse technique to analyze molecular hybrids of single-wall carbon nanotubes (SWNTs) wrapped in either single-stranded DNA or protein…”
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Single-molecule force spectroscopy reveals binding and bridging dynamics of PARP1 and PARP2 at DNA double-strand breaks by Bell, Nicholas A W, Molloy, Justin E

“…Poly(ADP-ribose) polymerases (PARPs) play key roles in DNA damage repair pathways in eukaryotic cells. Human PARPs 1 and 2 are catalytically activated by…”
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Asymmetric dynamics of DNA entering and exiting a strongly confining nanopore by Bell, Nicholas A. W., Chen, Kaikai, Ghosal, Sandip, Ricci, Maria, Keyser, Ulrich F.

“…In nanopore sensing, changes in ionic current are used to analyse single molecules in solution. The translocation dynamics of polyelectrolytes is of particular…”
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Ionic Current-Based Mapping of Short Sequence Motifs in Single DNA Molecules Using Solid-State Nanopores by Chen, Kaikai, Juhasz, Matyas, Gularek, Felix, Weinhold, Elmar, Tian, Yu, Keyser, Ulrich F, Bell, Nicholas A. W

“…Nanopore sensors show great potential for rapid, single-molecule determination of DNA sequence information. Here, we develop an ionic current-based method for…”
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Single-Molecule Observation of the Intermediates in a Catalytic Cycle by Ramsay, William J, Bell, Nicholas A. W, Qing, Yujia, Bayley, Hagan

“…The development of catalysts benefits from knowledge of the intermediate steps that accelerate the transformations of substrates into products. However, key…”
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Lipid-coated nanocapillaries for DNA sensing by Hernández-Ainsa, Silvia, Muus, Christoph, Bell, Nicholas A W, Steinbock, Lorenz J, Thacker, Vivek V, Keyser, Ulrich F

“…We report a simple and efficient way to accomplish the chemical modification of glass nanopores by means of lipid self-assembly. Lipid coating improves the…”
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Direction- and Salt-Dependent Ionic Current Signatures for DNA Sensing with Asymmetric Nanopores by Chen, Kaikai, Bell, Nicholas A.W., Kong, Jinglin, Tian, Yu, Keyser, Ulrich F.

“…Solid-state nanopores are promising tools for single-molecule detection of both DNA and proteins. In this study, we investigated the patterns of ionic current…”
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Translocation frequency of double-stranded DNA through a solid-state nanopore by Bell, Nicholas A W, Muthukumar, Murugappan, Keyser, Ulrich F

“…Solid-state nanopores are single-molecule sensors that measure changes in ionic current as charged polymers such as DNA pass through. Here, we present…”
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PEGylated surfaces for the study of DNA-protein interactions by atomic force microscopy by Akpinar, Bernice, Haynes, Philip J, Bell, Nicholas A W, Brunner, Katharina, Pyne, Alice L B, Hoogenboom, Bart W

“…DNA-protein interactions are vital to cellular function, with key roles in the regulation of gene expression and genome maintenance. Atomic force microscopy…”
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Free-standing graphene membranes on glass nanopores for ionic current measurements by Walker, Michael I., Weatherup, Robert S., Bell, Nicholas A. W., Hofmann, Stephan, Keyser, Ulrich F.

“…A method is established to reliably suspend graphene monolayers across glass nanopores as a simple, low cost platform to study ionic transport through graphene…”
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Nanopore analysis of amyloid fibrils formed by lysozyme aggregation by Martyushenko, Nikolay, Bell, Nicholas A W, Lamboll, Robin D, Keyser, Ulrich F

“…The measurement of single particle size distributions of amyloid fibrils is crucial for determining mechanisms of growth and toxicity. Nanopore sensing is an…”
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Multiplexed ionic current sensing with glass nanopores by Bell, Nicholas A W, Thacker, Vivek V, Hernández-Ainsa, Silvia, Fuentes-Perez, Maria E, Moreno-Herrero, Fernando, Liedl, Tim, Keyser, Ulrich F

“…We report a method for simultaneous ionic current measurements of single molecules across up to 16 solid state nanopore channels. Each device, costing less…”
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