Search Results - "Bell, Joshua"

Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment by Phillips-Cremins, Jennifer E., Sauria, Michael E.G., Sanyal, Amartya, Gerasimova, Tatiana I., Lajoie, Bryan R., Bell, Joshua S.K., Ong, Chin-Tong, Hookway, Tracy A., Guo, Changying, Sun, Yuhua, Bland, Michael J., Wagstaff, William, Dalton, Stephen, McDevitt, Todd C., Sen, Ranjan, Dekker, Job, Taylor, James, Corces, Victor G.

“…Understanding the topological configurations of chromatin may reveal valuable insights into how the genome and epigenome act in concert to control cell fate…”
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A Bundle of Relations: Collections, Collecting, and Communities by Bell, Joshua A

“…Anthropology has always involved collections and collecting. Collections helped give rise to the discipline's formation and were integral to theoretical…”
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Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation by Richardson, Tom G, Leyden, Genevieve M, Wang, Qin, Bell, Joshua A, Elsworth, Benjamin, Davey Smith, George, Holmes, Michael V

“…Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compare the genetically predicted effects of therapeutic targets…”
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Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study by Bell, Joshua A, Carslake, David, Wade, Kaitlin H, Richmond, Rebecca C, Langdon, Ryan J, Vincent, Emma E, Holmes, Michael V, Timpson, Nicholas J, Davey Smith, George

“…Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and…”
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Validation of genomic and transcriptomic models of homologous recombination deficiency in a real-world pan-cancer cohort by Leibowitz, Benjamin D, Dougherty, Bonnie V, Bell, Joshua S K, Kapilivsky, Joshuah, Michuda, Jackson, Sedgewick, Andrew J, Munson, Wesley A, Chandra, Tushar A, Dry, Jonathan R, Beaubier, Nike, Igartua, Catherine, Taxter, Timothy

“…With the introduction of DNA-damaging therapies into standard of care cancer treatment, there is a growing need for predictive diagnostics assessing homologous…”
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The Natural Course of Healthy Obesity Over 20 Years by Bell, Joshua A., MSc, Hamer, Mark, PhD, Sabia, Séverine, PhD, Singh-Manoux, Archana, PhD, Batty, G. David, PhD, Kivimaki, Mika, PhD

“…Efforts to understand the cardiovascular consequences of healthy obesity are ongoing (2); however, its conceptual validity and clinical value rest on the…”
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Dynamic responses of Bacteroides thetaiotaomicron during growth on glycan mixtures by Rogers, Theresa E., Pudlo, Nicholas A., Koropatkin, Nicole M., Bell, Joshua S. K., Moya Balasch, Monica, Jasker, Kevin, Martens, Eric C.

“…Summary Bacteroides thetaiotaomicron (Bt) is a human colonic symbiont that degrades many different complex carbohydrates (glycans), the identities and amounts…”
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Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe by Kivimäki, Mika, Kuosma, Eeva, Ferrie, Jane E, Luukkonen, Ritva, Nyberg, Solja T, Alfredsson, Lars, Batty, G David, Brunner, Eric J, Fransson, Eleonor, Goldberg, Marcel, Knutsson, Anders, Koskenvuo, Markku, Nordin, Maria, Oksanen, Tuula, Pentti, Jaana, Rugulies, Reiner, Shipley, Martin J, Singh-Manoux, Archana, Steptoe, Andrew, Suominen, Sakari B, Theorell, Töres, Vahtera, Jussi, Virtanen, Marianna, Westerholm, Peter, Westerlund, Hugo, Zins, Marie, Hamer, Mark, Bell, Joshua A, Tabak, Adam G, Jokela, Markus

“…Although overweight and obesity have been studied in relation to individual cardiometabolic diseases, their association with risk of cardiometabolic…”
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Associations of device-measured physical activity across adolescence with metabolic traits: Prospective cohort study by Bell, Joshua A, Hamer, Mark, Richmond, Rebecca C, Timpson, Nicholas J, Carslake, David, Davey Smith, George

“…Multiple occasions of device-measured physical activity have not been previously examined in relation to metabolic traits. We described associations of total…”
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Knowing your boundaries: no effect of tool-use on body representation following a gather-and-sort task by Bell, Joshua D., Macuga, Kristen L.

“…Internal representations of the body have received considerable attention in recent years, particularly in the context of tool-use. Results have supported the…”
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Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations by Miyashita, Minoru, Bell, Joshua S K, Wenric, Stephane, Karaesmen, Ezgi, Rhead, Brooke, Kase, Matthew, Kaneva, Kristiyana, De La Vega, Francisco M, Zheng, Yonglan, Yoshimatsu, Toshio F, Khramtsova, Galina, Liu, Fang, Zhao, Fangyuan, Howard, Frederick M, Nanda, Rita, Beaubier, Nike, White, Kevin P, Huo, Dezheng, Olopade, Olufunmilayo I

“…Endocrine-resistant HR+/HER2- breast cancer (BC) and triple-negative BC (TNBC) are of interest for molecularly informed treatment due to their aggressive…”
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Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: A cohort study by Bell, Joshua A, Wade, Kaitlin H, O'Keeffe, Linda M, Carslake, David, Vincent, Emma E, Holmes, Michael V, Timpson, Nicholas J, Davey Smith, George

“…The potential benefits of gaining body muscle for cardiovascular disease (CVD) susceptibility, and how these compare with the potential harms of gaining body…”
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GC skew defines distinct RNA polymerase pause sites in CpG island promoters by Kellner, Wendy A, Bell, Joshua S K, Vertino, Paula M

“…CpG islands (CGIs) are associated with over half of human gene promoters and are characterized by a unique chromatin environment and high levels of…”
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Puberty timing and adiposity change across childhood and adolescence: disentangling cause and consequence by O’Keeffe, Linda M, Frysz, Monika, Bell, Joshua A, Howe, Laura D, Fraser, Abigail

“…Abstract STUDY QUESTION Is earlier puberty more likely a result of adiposity gain in childhood than a cause of adiposity gain in adulthood? SUMMARY ANSWER…”
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MAKING KIN: Rawness, Porosity, and the Agencies by Bell, Joshua A.

“…This afterword to the special issue “Materiality, Belonging, and the Activation of Difference” begins and ends with Kim TallBear's notion of kin‐making as a…”
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Are tools truly incorporated as an extension of the body representation?: Assessing the evidence for tool embodiment by Bell, Joshua D., Macuga, Kristen L.

“…The predominant view on human tool-use suggests that an action-oriented body representation, the body schema , is altered to fit the tool being wielded, a…”
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Stability of metabolically healthy obesity over 8 years: the English Longitudinal Study of Ageing by Hamer, Mark, Bell, Joshua A, Sabia, Severine, Batty, G David, Kivimäki, Mika

“…ObjectiveMetabolically healthy obesity possibly reflects a transitional stage before the onset of metabolic dysfunction, but few studies have characterised…”
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Association between inflammatory biomarkers and all-cause, cardiovascular and cancer-related mortality by Singh-Manoux, Archana, Shipley, Martin J, Bell, Joshua A, Canonico, Marianne, Elbaz, Alexis, Kivimäki, Mika

“…The inflammatory biomarker α -acid glycoprotein (AGP) was found to have the strongest association with 5-year mortality in a recent study of 106 biomarkers. We…”
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Examining associations between physical activity and cardiovascular mortality using negative control outcomes by Hamer, Mark, Bauman, Adrian, Bell, Joshua A, Stamatakis, Emmanuel

“…Abstract Background The purpose of a negative control is to reproduce a condition that cannot involve the hypothesized causal mechanism, but does involve the…”
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Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis by Richardson, Tom G, Mykkänen, Juha, Pahkala, Katja, Ala-Korpela, Mika, Bell, Joshua A, Taylor, Kurt, Viikari, Jorma, Lehtimäki, Terho, Raitakari, Olli, Davey Smith, George

“…Abstract Background Individuals who are obese in childhood have an elevated risk of disease in adulthood. However, whether childhood adiposity directly impacts…”
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