Search Results - "Bell, Graeme"

Susumu Seino, MD, DMSci (1948–2021): A Pioneer in the Biology of Insulin Secretion by Accili, Domenico, Bell, Graeme I., Thorens, Bernard

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MODY: History, genetics, pathophysiology, and clinical decision making by FAJANS, Stefan S, BELL, Graeme I

“…Starting with known diabetic patients from the Diabetes Clinic, I recruited their apparently healthy and asymptomatic first-degree relatives (parents,…”
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RNA-seq analysis of allele-specific expression, hybrid effects, and regulatory divergence in hybrids compared with their parents from natural populations by Bell, Graeme D M, Kane, Nolan C, Rieseberg, Loren H, Adams, Keith L

“…Hybridization is a prominent process among natural plant populations that can result in phenotypic novelty, heterosis, and changes in gene expression. The…”
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In celebration of a century with insulin – Update of insulin gene mutations in diabetes by Støy, Julie, De Franco, Elisa, Ye, Honggang, Park, Soo-Young, Bell, Graeme I., Hattersley, Andrew T.

“…While insulin has been central to the pathophysiology and treatment of patients with diabetes for the last 100 years, it has only been since 2007 that genetic…”
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Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia by Fahrmann, Johannes, Grapov, Dmitry, Yang, Jun, Hammock, Bruce, Fiehn, Oliver, Bell, Graeme I, Hara, Manami

“…Nonobese diabetic (NOD) mice are a commonly used model of type 1 diabetes (T1D). However, not all animals will develop overt diabetes despite undergoing…”
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Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism by Savic, Daniel, Ye, Honggang, Aneas, Ivy, Park, Soo-Young, Bell, Graeme I, Nobrega, Marcelo A

“…Genome-wide association studies (GWAS) have consistently implicated noncoding variation within the TCF7L2 locus with type 2 diabetes (T2D) risk. While this…”
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Genomics of Compositae weeds: EST libraries, microarrays, and evidence of introgression by Lai, Zhao, Kane, Nolan C., Kozik, Alex, Hodgins, Kathryn A., Dlugosch, Katrina M., Barker, Michael S., Matvienko, Marta, Yu, Qian, Turner, Kathryn G., Pearl, Stephanie Anne, Bell, Graeme D. M., Zou, Yi, Grassa, Chris, Guggisberg, Alessia, Adams, Keith L., Anderson, James V., Horvath, David P., Kesseli, Richard V., Burke, John M., Michelmore, Richard W., Rieseberg, Loren H.

“…Premise of study: Weeds cause considerable environmental and economic damage. However, genomic characterization of weeds has lagged behind that of model plants…”
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Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population by Estrada, Karol, Aukrust, Ingvild, Bjørkhaug, Lise, Burtt, Noël P, Mercader, Josep M, García-Ortiz, Humberto, Huerta-Chagoya, Alicia, Moreno-Macías, Hortensia, Walford, Geoffrey, Flannick, Jason, Williams, Amy L, Gómez-Vázquez, María J, Fernandez-Lopez, Juan C, Martínez-Hernández, Angélica, Centeno-Cruz, Federico, Mendoza-Caamal, Elvia, Revilla-Monsalve, Cristina, Islas-Andrade, Sergio, Córdova, Emilio J, Soberón, Xavier, González-Villalpando, María E, Henderson, E, Wilkens, Lynne R, Le Marchand, Loic, Arellano-Campos, Olimpia, Ordóñez-Sánchez, Maria L, Rodríguez-Torres, Maribel, Rodríguez-Guillén, Rosario, Riba, Laura, Najmi, Laeya A, Jacobs, Suzanne B.R, Fennell, Timothy, Gabriel, Stacey, Fontanillas, Pierre, Hanis, Craig L, Lehman, Donna M, Jenkinson, Christopher P, Abboud, Hanna E, Bell, Graeme I, Cortes, Maria L, Boehnke, Michael, González-Villalpando, Clicerio, Orozco, Lorena, Haiman, Christopher A, Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A, Altshuler, David, Njølstad, Pål R, Florez, Jose C, MacArthur, Daniel G

“…IMPORTANCE Latino populations have one of the highest prevalences of type 2 diabetes worldwide. OBJECTIVES To investigate the association between rare…”
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Insulin gene mutations as a cause of permanent neonatal diabetes by Støy, Julie, Edghill, Emma L, Flanagan, Sarah E, Ye, Honggang, Paz, Veronica P, Pluzhnikov, Anna, Below, Jennifer E, Hayes, M. Geoffrey, Cox, Nancy J, Lipkind, Gregory M, Lipton, Rebecca B, Greeley, Siri Atma W, Patch, Ann-Marie, Ellard, Sian, Steiner, Donald F, Hattersley, Andrew T, Philipson, Louis H, Bell, Graeme I

“…We report 10 heterozygous mutations in the human insulin gene in 16 probands with neonatal diabetes. A combination of linkage and a candidate gene approach in…”
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Cost-Effectiveness of MODY Genetic Testing: Translating Genomic Advances Into Practical Health Applications by NAYLOR, Rochelle N, JOHN, Priya M, WINN, Aaron N, CARMODY, David, GREELEY, Siriatma W, PHILIPSON, Louis H, BELL, Graeme I, HUANG, Elbert S

“…OBJECTIVE To evaluate the cost-effectiveness of a genetic testing policy for HNF1A-, HNF4A-, and GCK-MODY in a hypothetical cohort of type 2 diabetic patients…”
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Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young by Fajans, Stefan S, Bell, Graeme I, Polonsky, Kenneth S

“…Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by nonketotic diabetes mellitus, an autosomal…”
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TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action by VILLAREAL, Dennis T, ROBERTSON, Heather, BELL, Graeme I, PATTERSON, Bruce W, TRAN, Hung, WICE, Burton, POLONSKY, Kenneth S

“…TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action Dennis T. Villareal 1 , Heather Robertson 1 , Graeme I. Bell 2 ,…”
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Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans by Cade, Brian E, Chen, Han, Stilp, Adrienne M, Gleason, Kevin J, Sofer, Tamar, Ancoli-Israel, Sonia, Arens, Raanan, Bell, Graeme I, Below, Jennifer E, Bjonnes, Andrew C, Chun, Sung, Conomos, Matthew P, Evans, Daniel S, Johnson, W Craig, Frazier-Wood, Alexis C, Lane, Jacqueline M, Larkin, Emma K, Loredo, Jose S, Post, Wendy S, Ramos, Alberto R, Rice, Ken, Rotter, Jerome I, Shah, Neomi A, Stone, Katie L, Taylor, Kent D, Thornton, Timothy A, Tranah, Gregory J, Wang, Chaolong, Zee, Phyllis C, Hanis, Craig L, Sunyaev, Shamil R, Patel, Sanjay R, Laurie, Cathy C, Zhu, Xiaofeng, Saxena, Richa, Lin, Xihong, Redline, Susan

“…Obstructive sleep apnea is a common disorder associated with increased risk for cardiovascular disease, diabetes, and premature mortality. Although there is…”
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Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood by Edghill, Emma L, Flanagan, Sarah E, Patch, Ann-Marie, Boustred, Chris, Parrish, Andrew, Shields, Beverley, Shepherd, Maggie H, Hussain, Khalid, Kapoor, Ritika R, Malecki, Maciej, MacDonald, Michael J, Støy, Julie, Steiner, Donald F, Philipson, Louis H, Bell, Graeme I, Hattersley, Andrew T, Ellard, Sian

“…Insulin gene (INS) mutations have recently been described as a cause of permanent neonatal diabetes (PND). We aimed to determine the prevalence, genetics, and…”
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Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted by Park, Soo-Young, Ye, Honggang, Steiner, Donald F., Bell, Graeme I.

“…Mutations in the preproinsulin protein that affect processing of preproinsulin to proinsulin or lead to misfolding of proinsulin are associated with diabetes…”
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Genome-Wide Association Study of Staphylococcus aureus Carriage in a Community-Based Sample of Mexican-Americans in Starr County, Texas by Brown, Eric L, Below, Jennifer E, Fischer, Rebecca S B, Essigmann, Heather T, Hu, Hao, Huff, Chad, Robinson, D Ashley, Petty, Lauren E, Aguilar, David, Bell, Graeme I, Hanis, Craig L

“…Staphylococcus aureus is the number one cause of hospital-acquired infections. Understanding host pathogen interactions is paramount to the development of more…”
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Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men by Chen, Han, Cade, Brian E, Gleason, Kevin J, Bjonnes, Andrew C, Stilp, Adrienne M, Sofer, Tamar, Conomos, Matthew P, Ancoli-Israel, Sonia, Arens, Raanan, Azarbarzin, Ali, Bell, Graeme I, Below, Jennifer E, Chun, Sung, Evans, Daniel S, Ewert, Ralf, Frazier-Wood, Alexis C, Gharib, Sina A, Haba-Rubio, José, Hagen, Erika W, Heinzer, Raphael, Hillman, David R, Johnson, W Craig, Kutalik, Zoltan, Lane, Jacqueline M, Larkin, Emma K, Lee, Seung Ku, Liang, Jingjing, Loredo, Jose S, Mukherjee, Sutapa, Palmer, Lyle J, Papanicolaou, George J, Penzel, Thomas, Peppard, Paul E, Post, Wendy S, Ramos, Alberto R, Rice, Ken, Rotter, Jerome I, Sands, Scott A, Shah, Neomi A, Shin, Chol, Stone, Katie L, Stubbe, Beate, Sul, Jae Hoon, Tafti, Mehdi, Taylor, Kent D, Teumer, Alexander, Thornton, Timothy A, Tranah, Gregory J, Wang, Chaolong, Wang, Heming, Warby, Simon C, Wellman, D Andrew, Zee, Phyllis C, Hanis, Craig L, Laurie, Cathy C, Gottlieb, Daniel J, Patel, Sanjay R, Zhu, Xiaofeng, Sunyaev, Shamil R, Saxena, Richa, Lin, Xihong, Redline, Susan

“…Obstructive sleep apnea (OSA) is a common heritable disorder displaying marked sexual dimorphism in disease prevalence and progression. Previous genetic…”
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Control of Pancreas and Liver Gene Expression by HNF Transcription Factors by Odom, Duncan T., Zizlsperger, Nora, Gordon, D. Benjamin, Bell, George W., Rinaldi, Nicola J., Murray, Heather L., Volkert, Tom L., Schreiber, Jörg, Rolfe, P. Alexander, Gifford, David K., Fraenkel, Ernest, Bell, Graeme I., Young, Richard A.

“…The transcriptional regulatory networks that specify and maintain human tissue diversity are largely uncharted. To gain insight into this circuitry, we used…”
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An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers by Savic, Daniel, Bell, Graeme I, Nobrega, Marcelo A

“…Genome-wide association studies (GWAS) have repeatedly shown an association between non-coding variants in the TCF7L2 locus and risk for type 2 diabetes (T2D),…”
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Mutations in the Insulin Gene Can Cause MODY and Autoantibody-Negative Type 1 Diabetes by Molven, Anders, Ringdal, Monika, Nordbø, Anita M, Raeder, Helge, Støy, Julie, Lipkind, Gregory M, Steiner, Donald F, Philipson, Louis H, Bergmann, Ines, Aarskog, Dagfinn, Undlien, Dag E, Joner, Geir, Søvik, Oddmund, Bell, Graeme I, Njølstad, Pål R

“…Mutations in the Insulin Gene Can Cause MODY and Autoantibody-Negative Type 1 Diabetes Anders Molven 1 2 , Monika Ringdal 3 4 , Anita M. Nordbø 3 4 , Helge…”
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