Search Results - "Bell, George W."

Predicting effective microRNA target sites in mammalian mRNAs by Agarwal, Vikram, Bell, George W, Nam, Jin-Wu, Bartel, David P

“…MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical…”
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HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers by Mendillo, Marc L., Santagata, Sandro, Koeva, Martina, Bell, George W., Hu, Rong, Tamimi, Rulla M., Fraenkel, Ernest, Ince, Tan A., Whitesell, Luke, Lindquist, Susan

“…Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival, and proliferation in model…”
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Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs by Baek, Daehyun, Bartel, David P, Garcia, David M, Shin, Chanseok, Bell, George W, Grimson, Andrew

“…A single miRNA can target hundreds of distinct transcripts, but some miRNAs such as C. elegans lsy-6 have very low target proficiency. The reasons behind this…”
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Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model by Weinberg, Robert A, Ma, Li, Reinhardt, Ferenc, Pan, Elizabeth, Soutschek, Jürgen, Bhat, Balkrishen, Marcusson, Eric G, Teruya-Feldstein, Julie, Bell, George W

“…Efforts to develop drugs that would prevent a primary tumor from spreading to new sites have been hampered by a lack of metastasis-specific targets. Working…”
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Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging by Mihaylova, Maria M., Cheng, Chia-Wei, Cao, Amanda Q., Tripathi, Surya, Mana, Miyeko D., Bauer-Rowe, Khristian E., Abu-Remaileh, Monther, Clavain, Laura, Erdemir, Aysegul, Lewis, Caroline A., Freinkman, Elizaveta, Dickey, Audrey S., La Spada, Albert R., Huang, Yanmei, Bell, George W., Deshpande, Vikram, Carmeliet, Peter, Katajisto, Pekka, Sabatini, David M., Yilmaz, Ömer H.

“…Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on…”
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Extensive alternative polyadenylation during zebrafish development by Ulitsky, Igor, Shkumatava, Alena, Jan, Calvin H, Subtelny, Alexander O, Koppstein, David, Bell, George W, Sive, Hazel, Bartel, David P

“…The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3' untranslated regions (3' UTRs), which are defined by cleavage and…”
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MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis by Cuiffo, Benjamin G., Campagne, Antoine, Bell, George W., Lembo, Antonio, Orso, Francesca, Lien, Evan C., Bhasin, Manoj K., Raimo, Monica, Hanson, Summer E., Marusyk, Andriy, El-Ashry, Dorraya, Hematti, Peiman, Polyak, Kornelia, Mechta-Grigoriou, Fatima, Mariani, Odette, Volinia, Stefano, Vincent-Salomon, Anne, Taverna, Daniela, Karnoub, Antoine E.

“…Mesenchymal stem/stromal cells (MSCs) are progenitor cells shown to participate in breast tumor stroma formation and to promote metastasis. Despite expanding…”
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YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells by Camargo, Fernando D., Gokhale, Sumita, Johnnidis, Jonathan B., Fu, Dongdong, Bell, George W., Jaenisch, Rudolf, Brummelkamp, Thijn R.

“…The mechanisms that regulate mammalian organ size are poorly understood. It is unclear whether the pathways that control organ size also impinge on…”
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MERAV: a tool for comparing gene expression across human tissues and cell types by Shaul, Yoav D, Yuan, Bingbing, Thiru, Prathapan, Nutter-Upham, Andy, McCallum, Scott, Lanzkron, Carolyn, Bell, George W, Sabatini, David M

“…The oncogenic transformation of normal cells into malignant, rapidly proliferating cells requires major alterations in cell physiology. For example, the…”
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Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors by Soldner, Frank, Hockemeyer, Dirk, Beard, Caroline, Gao, Qing, Bell, George W., Cook, Elizabeth G., Hargus, Gunnar, Blak, Alexandra, Cooper, Oliver, Mitalipova, Maisam, Isacson, Ole, Jaenisch, Rudolf

“…Induced pluripotent stem cells (iPSCs) derived from somatic cells of patients represent a powerful tool for biomedical research and may provide a source for…”
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Natural epigenetic polymorphisms lead to intraspecific variation in Arabidopsis gene imprinting by Pignatta, Daniela, Erdmann, Robert M, Scheer, Elias, Picard, Colette L, Bell, George W, Gehring, Mary

“…Imprinted gene expression occurs during seed development in plants and is associated with differential DNA methylation of parental alleles, particularly at…”
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Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras by Cohen, Malkiel A., Zhang, Shupei, Sengupta, Satyaki, Ma, Haiting, Bell, George W., Horton, Brendan, Sharma, Bandana, George, Rani E., Spranger, Stefani, Jaenisch, Rudolf

“…Neuroblastoma (NB), derived from the neural crest (NC), is the most common pediatric extracranial solid tumor. Here, we establish a platform that allows the…”
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Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy by El-Haibi, Christelle P., Bell, George W., Zhang, Jiangwen, Collmann, Anthony Y., Wood, David, Scherber, Cally M., Csizmadia, Eva, Mariani, Odette, Zhu, Cuihua, Campagne, Antoine, Toner, Mehmet, Bhatia, Sangeeta N., Irimia, Daniel, Vincent-Salomon, Anne, Karnoub, Antoine E.

“…Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the ability to differentiate into multiple mesoderm lineages in the course of normal tissue…”
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A regulatory program for excretory system regeneration in planarians by Scimone, M Lucila, Srivastava, Mansi, Bell, George W, Reddien, Peter W

“…Planarians can regenerate any missing body part, requiring mechanisms for the production of organ systems in the adult, including their prominent tubule-based…”
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Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT) by Papatheodorou, Panagiotis, Carette, Jan E, Bell, George W, Schwan, Carsten, Guttenberg, Gregor, Brummelkamp, Thijn R, Aktories, Klaus

“…Clostridium difficile infection (CDI) causes antibiotic-associated diarrhea and pseudomembranous colitis. Hypervirulent strains of the pathogen, which are…”
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Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression by Gao, Qing, Steine, Eveline J, Barrasa, M. Inmaculada, Hockemeyer, Dirk, Pawlak, Mathias, Fu, Dongdong, Reddy, Seshamma, Bell, George W, Jaenisch, Rudolf

“…Alterations in DNA methylation have been associated with genome-wide hypomethylation and regional de novo methylation in numerous cancers. De novo methylation…”
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Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast by Pokholok, Dmitry K., Harbison, Christopher T., Levine, Stuart, Cole, Megan, Hannett, Nancy M., Lee, Tong Ihn, Bell, George W., Walker, Kimberly, Rolfe, P. Alex, Herbolsheimer, Elizabeth, Zeitlinger, Julia, Lewitter, Fran, Gifford, David K., Young, Richard A.

“…Eukaryotic genomes are packaged into nucleosomes whose position and chemical modification state can profoundly influence regulation of gene expression. We…”
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Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes by Ince, Tan A., Richardson, Andrea L., Bell, George W., Saitoh, Maki, Godar, Samuel, Karnoub, Antoine E., Iglehart, James D., Weinberg, Robert A.

“…We investigated the influence of normal cell phenotype on the neoplastic phenotype by comparing tumors derived from two different normal human mammary…”
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Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression by Godar, Samuel, Ince, Tan A., Bell, George W., Feldser, David, Donaher, Joana Liu, Bergh, Jonas, Liu, Anne, Miu, Kevin, Watnick, Randolph S., Reinhardt, Ferenc, McAllister, Sandra S., Jacks, Tyler, Weinberg, Robert A.

“…The p53 tumor suppressor is a key mediator of cellular responses to various stresses. Here, we show that under conditions of basal physiologic and cell-culture…”
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Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways by Dang, Michelle, Armbruster, Nicole, Miller, Miles A., Cermeno, Efrain, Hartmann, Monika, Bell, George W., Root, David E., Lauffenburger, Douglas A., Lodish, Harvey F., Herrlich, Andreas

“…Ectodomain cleavage of cell-surface proteins by A disintegrin and metalloproteinases (ADAMs) is highly regulated, and its dysregulation has been linked to many…”
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