Search Results - "Bell, Alexander T.F."

Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors by Çuburu, Nicolas, Bialkowski, Lukasz, Pontejo, Sergio M., Sethi, Shiv K., Bell, Alexander T. F., Kim, Rina, Thompson, Cynthia D., Lowy, Douglas R., Schiller, John T.

“…Tumor infiltration by T cells profoundly affects cancer progression and responses to immunotherapy. However, the tumor immunosuppressive microenvironment can…”
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Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence by Zhang, Shuming, Yuan, Long, Danilova, Ludmila, Mo, Guanglan, Zhu, Qingfeng, Deshpande, Atul, Bell, Alexander T F, Elisseeff, Jennifer, Popel, Aleksander S, Anders, Robert A, Jaffee, Elizabeth M, Yarchoan, Mark, Fertig, Elana J, Kagohara, Luciane T

“…Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of…”
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Abstract A108: Spatial transcriptomic analysis of venous invasion in human pancreatic adenocarcinoma reveals widespread attenuation in features associated with aggression and mortality by Bell, Alexander T.F., Chianchiano, Peter, Hirose, Katsuya, Gisder, Doreen, Damanakis, Alexander I., Kagohara, Luciane T., Fertig, Elana J., Wood, Laura D.

“…In pancreatic ductal adenocarcinoma (PDAC), venous invasion (VI) is a necessary precursor to hematogenous dissemination, but little is known about the…”
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Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces by Deshpande, Atul, Loth, Melanie, Sidiropoulos, Dimitrios N, Zhang, Shuming, Yuan, Long, Bell, Alexander T F, Zhu, Qingfeng, Ho, Won Jin, Santa-Maria, Cesar, Gilkes, Daniele M, Williams, Stephen R, Uytingco, Cedric R, Chew, Jennifer, Hartnett, Andrej, Bent, Zachary W, Favorov, Alexander V, Popel, Aleksander S, Yarchoan, Mark, Kiemen, Ashley, Wu, Pei-Hsun, Fujikura, Kohei, Wirtz, Denis, Wood, Laura D, Zheng, Lei, Jaffee, Elizabeth M, Anders, Robert A, Danilova, Ludmila, Stein-O'Brien, Genevieve, Kagohara, Luciane T, Fertig, Elana J

“…Recent advances in spatial transcriptomics (STs) enable gene expression measurements from a tissue sample while retaining its spatial context. This technology…”
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PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration by Bell, Alexander T F, Mitchell, Jacob T, Kiemen, Ashley L, Lyman, Melissa, Fujikura, Kohei, Lee, Jae W, Coyne, Erin, Shin, Sarah M, Nagaraj, Sushma, Deshpande, Atul, Wu, Pei-Hsun, Sidiropoulos, Dimitrios N, Erbe, Rossin, Stern, Jacob, Chan, Rena, Williams, Stephen, Chell, James M, Ciotti, Lauren, Zimmerman, Jacquelyn W, Wirtz, Denis, Ho, Won Jin, Zaidi, Neeha, Thompson, Elizabeth, Jaffee, Elizabeth M, Wood, Laura D, Fertig, Elana J, Kagohara, Luciane T

“…This study introduces a new imaging, spatial transcriptomics (ST), and single-cell RNA-sequencing integration pipeline to characterize neoplastic cell state…”
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Abstract B107: Spatial transcriptomics analysis of PanIN reveals loss of pro-inflammatory signaling and the presence of cancer-associated fibroblasts by Bell, Alexander T.F., Mitchell, Jacob T., Kiemen, Ashley L., Lyman, Melissa, Fujikura, Kohei, Lee, Jae W., Coyne, Erin, Shin, Sarah M., Wu, Pei-Hsun, Zimmerman, Jacquelyn W., Wirtz, Denis, Ho, Won J., Zaidi, Neeha, Thompson, Elizabeth, Jaffee, Elizabeth M., Wood, Laura D., Fertig, Elana J., Kagohara, Luciane T.

“…Pancreatic intraepithelial neoplasia (PanIN) is a premalignant lesion that potentially progresses into pancreatic ductal adenocarcinoma (PDAC). Since PanIN…”
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