Search Results - "Belknap, John K"

Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function by Shi, Xiao, Walter, Nicole A R, Harkness, John H, Neve, Kim A, Williams, Robert W, Lu, Lu, Belknap, John K, Eshleman, Amy J, Phillips, Tamara J, Janowsky, Aaron

“…Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and β-phenethylamine stimulate the G protein-coupled trace…”
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Toward Understanding the Genetics of Alcohol Drinking through Transcriptome Meta-Analysis by Mulligan, Megan K., Ponomarev, Igor, Hitzemann, Robert J., Belknap, John K., Tabakoff, Boris, Harris, R. Adron, Crabbe, John C., Blednov, Yuri A., Grahame, Nicholas J., Phillips, Tamara J., Finn, Deborah A., Hoffman, Paula L., Iyer, Vishwanath R., Koob, George F., Bergeson, Susan E.

“…Much evidence from studies in humans and animals supports the hypothesis that alcohol addiction is a complex disease with both hereditary and environmental…”
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Evaluation of levodopa dose and magnitude of dopamine depletion as risk factors for levodopa-induced dyskinesia in a rat model of Parkinson's disease by Putterman, Daniel B, Munhall, Adam C, Kozell, Laura B, Belknap, John K, Johnson, Steven W

“…Levodopa dose and severity of Parkinson's disease (PD) are recognized risk factors for levodopa-induced dyskinesia (LID) in humans. The purpose of the present…”
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In Silico Mapping of Complex Disease-Related Traits in Mice by Grupe, Andrew, Germer, Soren, Usuka, Jonathan, Aud, Dee, Belknap, John K., Klein, Robert F., Ahluwalia, Mandeep K., Higuchi, Russell, Peltz, Gary

“…Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for…”
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Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception by Mogil, J S, Wilson, S G, Bon, K, Lee, S E, Chung, K, Raber, P, Pieper, J O, Hain, H S, Belknap, J K, Hubert, L, Elmer, G I, Chung, J M, Devor, M

“…It is generally acknowledged that humans display highly variable sensitivity to pain, including variable responses to identical injuries or pathologies. The…”
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Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping by Belknap, John K

“…A chromosome substitution strain (CSS) is an inbred strain in which one chromosome has been substituted from a different inbred strain by repeated…”
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NMDA alters rotenone toxicity in rat substantia nigra zona compacta and ventral tegmental area dopamine neurons by Munhall, Adam C., Wu, Yan-Na, Belknap, John K., Meshul, Charles K., Johnson, Steven W.

“…► Slices of rat midbrain were perfused with rotenone and/or NMDA. ► Rotenone caused destruction of dopamine neuron dendrites in SNC and VTA. ► A high…”
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Quantitative Trait Loci Involved in Genetic Predisposition to Acute Alcohol Withdrawal in Mice by Buck, Kari Johnson, Metten, Pamela, Belknap, John K, Crabbe, John C

“…Alcohol dependence (alcoholism) is accompanied by evidence of tolerance, withdrawal (physiological dependence), or compulsive behavior related to alcohol use…”
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Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis by Mogil, J S, Wilson, S G, Bon, K, Lee, S E, Chung, K, Raber, P, Pieper, J O, Hain, H S, Belknap, J K, Hubert, L, Elmer, G I, Chung, J M, Devor, M

“…Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to…”
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The Complexity of Alcohol Drinking: Studies in Rodent Genetic Models by Crabbe, John C., Phillips, Tamara J., Belknap, John K.

“…Risk for alcohol dependence in humans has substantial genetic contributions. Successful rodent models generally attempt to address only selected features of…”
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Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice by Rhodes, Justin S., Best, Karyn, Belknap, John K., Finn, Deborah A., Crabbe, John C.

“…Because of intrinsic differences between humans and mice, no single mouse model can represent all features of a complex human trait such as alcoholism. It is…”
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Confirmation and Fine Mapping of Chromosomal Regions Influencing Peak Bone Mass in Mice by Klein, Robert F., Carlos, Amy S., Vartanian, Kristina A., Chambers, Virginia K., Turner, Renn J., Phillips, Tamara J., Belknap, John K., Orwoll, Eric S.

“…Bone mineral density (BMD) is determined by both environmental influences and polygenic inheritance. The extreme difficulty of dissecting out environmental…”
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Chromosomal loci influencing chronic alcohol withdrawal severity by Bergeson, Susan E, Kyle Warren, R, Crabbe, John C, Metten, Pamela, Gene Erwin, V, Belknap, John K

“…Ethanol (alcohol) withdrawal-induced convulsions are a key index of physical dependence on ethanol and a clinically important consequence of alcohol abuse in…”
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Dual-Trait Selection for Ethanol Consumption and Withdrawal: Genetic and Transcriptional Network Effects by Metten, Pamela, Iancu, Ovidiu D., Spence, Stephanie E., Walter, Nicole A. R., Oberbeck, Denesa, Harrington, Christina A., Colville, Alexandre, McWeeney, Shannon, Phillips, Tamara J., Buck, Kari J., Crabbe, John C., Belknap, John K., Hitzemann, Robert J.

“…Background Data from C57BL/6J (B6) × DBA/2J (D2) F2 intercrosses (B6xD2 F2), standard and recombinant inbred strains, and heterogeneous stock mice indicate…”
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Regulation of Bone Mass in Mice by the Lipoxygenase Gene Alox15 by Klein, Robert F., Allard, John, Avnur, Zafrira, Nikolcheva, Tania, Rotstein, David, Carlos, Amy S., Shea, Marie, Waters, Ruth V., Belknap, John K., Peltz, Gary, Orwoll, Eric S.

“…The development of osteoporosis involves the interaction of multiple environmental and genetic factors. Through combined genetic and genomic approaches, we…”
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Genetic factors involved in risk for methamphetamine intake and sensitization by Belknap, John K, McWeeney, Shannon, Reed, Cheryl, Burkhart-Kasch, Sue, McKinnon, Carrie S, Li, Na, Baba, Harue, Scibelli, Angela C, Hitzemann, Robert, Phillips, Tamara J

“…Lines of mice were created by selective breeding for the purpose of identifying genetic mechanisms that influence the magnitude of the selected trait and to…”
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Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition by Mukherjee, Aditi, Larson, Emily A, Carlos, Amy S, Belknap, John K, Rotwein, Peter, Klein, Robert F

“…Osteoporosis, the most common skeletal disorder, is characterized by low bone mineral density (BMD) and an increased risk of fragility fractures. BMD is the…”
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SNPs matter: impact on detection of differential expression by Walter, Nicole A R, McWeeney, Shannon K, Peters, Sandra T, Belknap, John K, Hitzemann, Robert, Buck, Kari J

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Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse by Belknap, John K, Metten, Pamela, Beckley, Ethan H, Crabbe, John C

“…Vulnerability to abused drugs is influenced by multiple genes unique to each drug and to risk genes for polydrug abuse. If several inbred mouse strains respond…”
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Impaired memory and reduced sensitivity to the circadian period lengthening effects of methamphetamine in mice selected for high methamphetamine consumption by Olsen, Reid H.J., Allen, Charles N., Derkach, Victor A., Phillips, Tamara J., Belknap, John K., Raber, Jacob

“…•MALDR mice show spatial memory retention.•MAHDR mice do not show spatial memory retention.•MAHDR mice have more GluR2 AMPA receptor subunits in the…”
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