Search Results - "Belkina, Natalya"
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Quantitative Tyrosine Phosphoproteomics of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor-treated Lung Adenocarcinoma Cells Reveals Potential Novel Biomarkers of Therapeutic Response
Published in Molecular & cellular proteomics (01-05-2017)“…Mutations in the Epidermal growth factor receptor (EGFR) kinase domain, such as the L858R missense mutation and deletions spanning the conserved sequence…”
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LOK Is a Major ERM Kinase in Resting Lymphocytes and Regulates Cytoskeletal Rearrangement through ERM Phosphorylation
Published in Proceedings of the National Academy of Sciences - PNAS (24-03-2009)“…ERM (ezrin-radixin-moesin) proteins mediate linkage of act in cytoskeleton to plasma membrane in many cells. ERM activity is regulated in part by…”
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HIV infection of T cells: actin-in and actin-out
Published in Science signaling (14-04-2009)“…Three studies shed light on the decade-old observation that the actin cytoskeleton is hijacked to facilitate entry of HIV into its target cells. Polymerization…”
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Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice
Published in Blood (12-01-2012)“…ERM (ezrin, radixin moesin) proteins in lymphocytes link cortical actin to plasma membrane, which is regulated in part by ERM protein phosphorylation. To…”
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Loss of ATM kinase activity leads to embryonic lethality in mice
Published in The Journal of cell biology (06-08-2012)“…Ataxia telangiectasia (A-T) mutated (ATM) is a key deoxyribonucleic acid (DNA) damage signaling kinase that regulates DNA repair, cell cycle checkpoints, and…”
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Caspase Cleavages of the Lymphocyte-oriented Kinase Prevent Ezrin, Radixin, and Moesin Phosphorylation during Apoptosis
Published in The Journal of biological chemistry (06-05-2016)“…The lymphocyte-oriented kinase (LOK), also called serine threonine kinase 10 (STK10), is synthesized mainly in lymphocytes. It is involved in lymphocyte…”
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Identifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics
Published in Proteomics (Weinheim) (01-01-2015)“…Mutations in the epidermal growth factor receptor (EGFR) kinase domain occur in 10–30% of lung adenocarcinoma and are associated with tyrosine kinase inhibitor…”
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Activation of Moesin, a Protein That Links Actin Cytoskeleton to the Plasma Membrane, Occurs by Phosphatidylinositol 4,5-bisphosphate (PIP2) Binding Sequentially to Two Sites and Releasing an Autoinhibitory Linker
Published in The Journal of biological chemistry (11-05-2012)“…Many cellular processes depend on ERM (ezrin, moesin, and radixin) proteins mediating regulated linkage between plasma membrane and actin cytoskeleton…”
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Independence of protein kinase C-delta activity from activation loop phosphorylation: structural basis and altered functions in cells
Published in The Journal of biological chemistry (28-04-2006)“…Activation loop phosphorylation plays critical regulatory roles for many kinases. Unlike other protein kinase Cs (PKC), PKC-delta does not require…”
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Exceptional Disfavor for Proline at the P+1 Position among AGC and CAMK Kinases Establishes Reciprocal Specificity between Them and the Proline-directed Kinases
Published in The Journal of biological chemistry (18-03-2005)“…To precisely regulate critical signaling pathways, two kinases that phosphorylate distinct sites on the same protein substrate must have mutually exclusive…”
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QUANTITATIVE AND QUALITATIVE COMPOSITION OF ORGANIC MATTER AND ITS TRANSFORMATION IN A SURFACE LAYER OF LAKE ONEGO SEDIMENTS
Published in Trudy Karelʹskogo nauchnogo t͡s︡entra Rossiĭskoĭ akademii nauk (01-10-2017)“…The elemental composition of the organic matter of bottom sediments was calculated in the paper. Changes of quantitative and qualitative composition of organic…”
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Latitudinal patterns of shifts in cladoceran communities throughout the Holocene: A paleoecological case study of northwestern Russia
Published in Quaternary international (30-10-2024)“…Paleolimnology is a rapidly expanding field within the natural sciences. To date, many scientific papers have been published focusing on studies of remains…”
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An Assay to Monitor the Engagement and Modulation of CD6 on T cells as a Clinical Biomarker of Treatment with Itolizumab
Published in The Journal of immunology (1950) (01-05-2021)“…Abstract Itolizumab is a novel first-in-class monoclonal antibody that selectively targets the co-stimulatory molecule CD6, a receptor that is highly expressed…”
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Ste20-like kinase, SLK, a novel mediator of podocyte integrity
Published in American journal of physiology. Renal physiology (01-07-2018)“…SLK is essential for embryonic development and may play a key role in wound healing, tumor growth, and metastasis. Expression and activation of SLK are…”
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Abstract 1671: Evaluation of total PD-1 expression using multi-color flow cytometry in metastatic non-small Cell lung cancer patients treated with multi-neoantigen vector (ADXS-503) alone and in combination of pembrolizumab to assess T-cell & T-cell memory subsets
Published in Cancer research (Chicago, Ill.) (01-07-2021)“…Abstract Precision for Medicine (Precision) developed and qualified two 17 color flow immunophenotyping assays to be used as pharmacodynamic biomarkers for…”
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Enhanced Effector Function of CD8+T Cells From Healthy Controls and HIV-Infected Patients Occurs Through Thrombin Activation of Protease-Activated Receptor 1
Published in The Journal of infectious diseases (15-02-2013)“…Disruption of vascular integrity by trauma and other tissue insults leads to inflammation and activation of the coagulation cascade. The serine protease…”
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GEOGRAPHIC INFORMATION SYSTEM “BIOLOGICAL RESOURCES OF ONEGO LAKE”
Published in InterCarto. InterGIS (25-06-2018)Get full text
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