Search Results - "Belkina, Anna C"

BET domain co-regulators in obesity, inflammation and cancer by Belkina, Anna C., Denis, Gerald V.

“…Key Points Mammalian BET proteins, a class of transcriptional co-regulators that contain dual, mutually related bromodomain motifs and an extraterminal domain,…”
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Automated optimized parameters for T-distributed stochastic neighbor embedding improve visualization and analysis of large datasets by Belkina, Anna C., Ciccolella, Christopher O., Anno, Rina, Halpert, Richard, Spidlen, Josef, Snyder-Cappione, Jennifer E.

“…Accurate and comprehensive extraction of information from high-dimensional single cell datasets necessitates faithful visualizations to assess biological…”
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BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses by Belkina, Anna C, Nikolajczyk, Barbara S, Denis, Gerald V

“…Histone acetylation regulates activation and repression of multiple inflammatory genes known to play critical roles in chronic inflammatory diseases. However,…”
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Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation by Bharath, Leena P., Agrawal, Madhur, McCambridge, Grace, Nicholas, Dequina A., Hasturk, Hatice, Liu, Jing, Jiang, Kai, Liu, Rui, Guo, Zhenheng, Deeney, Jude, Apovian, Caroline M., Snyder-Cappione, Jennifer, Hawk, Gregory S., Fleeman, Rebecca M., Pihl, Riley M.F., Thompson, Katherine, Belkina, Anna C., Cui, Licong, Proctor, Elizabeth A., Kern, Philip A., Nikolajczyk, Barbara S.

“…Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing…”
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Clinical trials for BET inhibitors run ahead of the science by Andrieu, Guillaume, Belkina, Anna C., Denis, Gerald V.

“…Several cancer clinical trials for small molecule inhibitors of BET bromodomain proteins have been initiated. There is enthusiasm for the anti-proliferative…”
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BET bromodomain inhibition as a novel strategy for reactivation of HIV-1 by Banerjee, Camellia, Archin, Nancie, Michaels, Daniel, Belkina, Anna C., Denis, Gerald V., Bradner, James, Sebastiani, Paola, Margolis, David M., Montano, Monty

“…BET bromodomain antagonist JQ1 reactivates HIV‐1, while suppressing T cell activation genes, and upregulating histone modification genes that favor increased…”
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B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile by DeFuria, Jason, Belkina, Anna C., Jagannathan-Bogdan, Madhumita, Snyder-Cappione, Jennifer, Carr, Jordan David, Nersesova, Yanina R., Markham, Douglas, Strissel, Katherine J., Watkins, Amanda A., Zhu, Min, Allen, Jessica, Bouchard, Jacqueline, Toraldo, Gianluca, Jasuja, Ravi, Obin, Martin S., McDonnell, Marie E., Apovian, Caroline, Denis, Gerald V., Nikolajczyk, Barbara S.

“…Patients with type 2 diabetes (T2D) have disease-associated changes in B-cell function, but the role these changes play in disease pathogenesis is not well…”
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BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response by Andrieu, Guillaume P., Shafran, Jordan S., Smith, Charlotte L., Belkina, Anna C., Casey, Allison N., Jafari, Naser, Denis, Gerald V.

“…Therapeutic strategies aiming to leverage anti-tumor immunity are being intensively investigated as they show promising results in cancer therapy. The…”
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Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity by Shenoy, Anukul T., Lyon De Ana, Carolina, Arafa, Emad I., Salwig, Isabelle, Barker, Kimberly A., Korkmaz, Filiz T., Ramanujan, Aditya, Etesami, Neelou S., Soucy, Alicia M., Martin, Ian M. C., Tilton, Brian R., Hinds, Anne, Goltry, Wesley N., Kathuria, Hasmeena, Braun, Thomas, Jones, Matthew R., Quinton, Lee J., Belkina, Anna C., Mizgerd, Joseph P.

“…Barrier tissues are populated by functionally plastic CD4 + resident memory T (T RM ) cells. Whether the barrier epithelium regulates CD4 + T RM cell…”
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HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction by Akiyama, Hisashi, Miller, Caitlin M., Ettinger, Chelsea R., Belkina, Anna C., Snyder-Cappione, Jennifer E., Gummuluru, Suryaram

“…Low levels of type I interferon (IFN-I) are thought to be a driving force for immune activation and T-cell exhaustion in HIV-1 infected individuals on…”
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BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell by Deeney, Jude T, Belkina, Anna C, Shirihai, Orian S, Corkey, Barbara E, Denis, Gerald V

“…Displacement of Bromodomain and Extra-Terminal (BET) proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET…”
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The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis by Belkina, Anna C., Blanton, Wanda P., Nikolajczyk, Barbara S., Denis, Gerald V.

“…Brd2 lentivirus transduction of hematopoietic stem cells and immune reconstitution of mice shows that the Brd2 pathway affects both hematopoiesis and mitogenic…”
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Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment by Vanuytsel, Kim, Villacorta-Martin, Carlos, Lindstrom-Vautrin, Jonathan, Wang, Zhe, Garcia-Beltran, Wilfredo F., Vrbanac, Vladimir, Parsons, Dylan, Lam, Evan C., Matte, Taylor M., Dowrey, Todd W., Kumar, Sara S., Li, Mengze, Wang, Feiya, Yeung, Anthony K., Mostoslavsky, Gustavo, Dries, Ruben, Campbell, Joshua D., Belkina, Anna C., Balazs, Alejandro B., Murphy, George J.

“…The human hematopoietic stem cell harbors remarkable regenerative potential that can be harnessed therapeutically. During early development, hematopoietic stem…”
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A targetable ‘rogue’ neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS by Herrera, Victoria L. M., Walkey, Allan J., Nguyen, Mai Q., Gromisch, Christopher M., Mosaddhegi, Julie Z., Gromisch, Matthew S., Jundi, Bakr, Lukassen, Soeren, Carstensen, Saskia, Denis, Ridiane, Belkina, Anna C., Baron, Rebecca M., Pinilla-Vera, Mayra, Mueller, Meike, Kimberly, W. Taylor, Goldstein, Joshua N., Lehmann, Irina, Shih, Angela R., Eils, Roland, Levy, Bruce D., Ruiz-Opazo, Nelson

“…Neutrophil-mediated secondary tissue injury underlies acute respiratory distress syndrome (ARDS) and progression to multi-organ-failure (MOF) and death,…”
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Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer by Kartha, Vinay K, Alamoud, Khalid A, Sadykov, Khikmet, Nguyen, Bach-Cuc, Laroche, Fabrice, Feng, Hui, Lee, Jina, Pai, Sara I, Varelas, Xaralabos, Egloff, Ann Marie, Snyder-Cappione, Jennifer E, Belkina, Anna C, Bais, Manish V, Monti, Stefano, Kukuruzinska, Maria A

“…Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to…”
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Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging by Belkina, Anna C, Starchenko, Alina, Drake, Katherine A, Proctor, Elizabeth A, Pihl, Riley M F, Olson, Alex, Lauffenburger, Douglas A, Lin, Nina, Snyder-Cappione, Jennifer E

“…Even with effective viral control, HIV-infected individuals are at a higher risk for morbidities associated with older age than the general population, and…”
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Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia by Kamata, Hirofumi, Yamamoto, Kazuko, Wasserman, Gregory A, Zabinski, Mary C, Yuen, Constance K, Lung, Wing Yi, Gower, Adam C, Belkina, Anna C, Ramirez, Maria I, Deng, Jane C, Quinton, Lee J, Jones, Matthew R, Mizgerd, Joseph P

“…Airway epithelial cell responses are critical to the outcome of lung infection. In this study, we aimed to identify unique contributions of epithelial cells…”
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B cells promote obesity‐associated periodontitis and oral pathogen‐associated inflammation by Zhu, Min, Belkina, Anna C., DeFuria, Jason, Carr, Jordan D., Van Dyke, Thomas E., Gyurko, Robert, Nikolajczyk, Barbara S.

“…B cells promote bone loss and inflammation in obesity‐associated periodontitis, but play a modest role in periodontitis of lean hosts. Individuals with T2D and…”
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B cells in the pneumococcus-infected lung are heterogeneous and require CD4 + T cell help including CD40L to become resident memory B cells by Etesami, Neelou S, Barker, Kimberly A, Shenoy, Anukul T, De Ana, Carolina Lyon, Arafa, Emad I, Grifno, Gabrielle N, Matschulat, Adeline M, Vannini, Michael E, Pihl, Riley M F, Breen, Michael P, Soucy, Alicia M, Goltry, Wesley N, Ha, Catherine T, Betsuyaku, Hanae, Browning, Jeffrey L, Varelas, Xaralabos, Traber, Katrina E, Jones, Matthew R, Quinton, Lee J, Maglione, Paul J, Nia, Hadi T, Belkina, Anna C, Mizgerd, Joseph P

“…Recovery from respiratory pneumococcal infections generates lung-localized protection against heterotypic bacteria, mediated by resident memory lymphocytes…”
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Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection by Yuen, Rachel R, Steiner, Dylan, Pihl, Riley M F, Chavez, Elizabeth, Olson, Alex, Smith, Erika L, Baird, Lillia A, Korkmaz, Filiz, Urick, Patricia, Sagar, Manish, Berrigan, Jacob L, Gummuluru, Suryaram, Corley, Ronald B, Quillen, Karen, Belkina, Anna C, Mostoslavsky, Gustavo, Rifkin, Ian R, Kataria, Yachana, Cappione, 3rd, Amedeo J, Gao, Wenda, Lin, Nina H, Bhadelia, Nahid, Snyder-Cappione, Jennifer E

“…The COVID-19 pandemic has drastically impacted work, economy, and way of life. Sensitive measurement of SARS-CoV-2 specific antibodies would provide new…”
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