Search Results - "Belkaid, Yasmine"
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The influence of skin microorganisms on cutaneous immunity
Published in Nature reviews. Immunology (01-06-2016)“…Key Points The skin is a complex and dynamic ecosystem inhabited by many microorganisms. The capacity of a given microorganism to trigger or promote disease is…”
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Microbial guardians of skin health
Published in Science (American Association for the Advancement of Science) (18-01-2019)“…Skin microbes can promote skin immunity, repair, and antimicrobial defense Skin, our largest and outermost organ, faces numerous challenges, including wounds,…”
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Compartmentalized and systemic control of tissue immunity by commensals
Published in Nature immunology (01-07-2013)“…The body is composed of various tissue microenvironments with finely tuned local immunosurveillance systems, many of which are in close apposition with…”
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Role of the Microbiota in Immunity and Inflammation
Published in Cell (27-03-2014)“…The microbiota plays a fundamental role on the induction, training, and function of the host immune system. In return, the immune system has largely evolved as…”
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Gut Microbiota: The Link to Your Second Brain
Published in Cell (09-04-2015)“…Serotonin is a highly ubiquitous signaling molecule that plays a role in the regulation of various physiological functions. Several lines of evidence,…”
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Contextual control of skin immunity and inflammation by Corynebacterium
Published in The Journal of experimental medicine (05-03-2018)“…How defined microbes influence the skin immune system remains poorly understood. Here we demonstrate that , dominant members of the skin microbiota, promote a…”
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Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis
Published in Blood (12-01-2017)“…The microbiota is known to influence the generation of hematopoietic progenitors, although the pathways underlying this process are still poorly understood…”
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Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis
Published in Science (American Association for the Advancement of Science) (28-03-2014)“…The intestinal microbiota and tissue-resident myeloid cells promote immune responses that maintain intestinal homeostasis in the host. However, the cellular…”
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Linking the Microbiota, Chronic Disease, and the Immune System
Published in Trends in endocrinology and metabolism (01-12-2016)“…Chronic inflammatory diseases (CIDs) are the most important causes of mortality in the world today and are on the rise. We now know that immune-driven…”
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How microbiota improve immunotherapy
Published in Science (American Association for the Advancement of Science) (27-08-2021)“…Ligands derived from the gut microbiota enhance cancer immunotherapy Animals have coevolved with complex communities of microorganisms living on barrier…”
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Gut-educated IgA plasma cells defend the meningeal venous sinuses
Published in Nature (London) (19-11-2020)“…The central nervous system has historically been viewed as an immune-privileged site, but recent data have shown that the meninges—the membranes that surround…”
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MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Published in Science (American Association for the Advancement of Science) (25-10-2019)“…How early-life colonization and subsequent exposure to the microbiota affect long-term tissue immunity remains poorly understood. Here, we show that the…”
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Infection trains the host for microbiota-enhanced resistance to pathogens
Published in Cell (04-02-2021)“…The microbiota shields the host against infections in a process known as colonization resistance. How infections themselves shape this fundamental process…”
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Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury
Published in Science (American Association for the Advancement of Science) (04-01-2019)“…Barrier tissues are primary targets of environmental stressors and are home to the largest number of antigen-experienced lymphocytes in the body, including…”
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction
Published in Cell (22-08-2019)“…Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we…”
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Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring
Published in Science (American Association for the Advancement of Science) (27-08-2021)“…Mom’s IL-6 rewires baby’s gut immunity Most infections that occur during pregnancy are mild and transient. However, whether such pathogen encounters can shape…”
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Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair
Published in Cell (08-02-2018)“…Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We explored how the microbiota was sensed by the immune system and the…”
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Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
Published in Science (American Association for the Advancement of Science) (22-11-2013)“…The gut microbiota influences both local and systemic inflammation. Inflammation contributes to development, progression, and treatment of cancer, but it…”
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Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment
Published in Nature immunology (01-02-2016)“…Group 3 innate lymphoid cells have low expression of the transcription factor GATA-3. Zhu and colleagues show that despite its low expression, GATA-3 is…”
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Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome
Published in Cell (06-10-2016)“…While conventional pathogenic protists have been extensively studied, there is an underappreciated constitutive protist microbiota that is an integral part of…”
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