Search Results - "Belk, Julia A"

Measurements and Performance Factor Comparisons of Magnetic Materials at High Frequency by Hanson, Alex J., Belk, Julia A., Seungbum Lim, Sullivan, Charles R., Perreault, David J.

“…The design of power magnetic components for operation at high frequency (HF, 3-30 MHz) has been hindered by a lack of magnetic material performance data and by…”
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Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions by Flynn, Ryan A., Belk, Julia A., Qi, Yanyan, Yasumoto, Yuki, Wei, Jin, Alfajaro, Mia Madel, Shi, Quanming, Mumbach, Maxwell R., Limaye, Aditi, DeWeirdt, Peter C., Schmitz, Cameron O., Parker, Kevin R., Woo, Elizabeth, Chang, Howard Y., Horvath, Tamas L., Carette, Jan E., Bertozzi, Carolyn R., Wilen, Craig B., Satpathy, Ansuman T.

“…SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using comprehensive identification of RNA-binding proteins by mass spectrometry…”
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Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses by Wong, Rachel, Belk, Julia A., Govero, Jennifer, Uhrlaub, Jennifer L., Reinartz, Dakota, Zhao, Haiyan, Errico, John M., D’Souza, Lucas, Ripperger, Tyler J., Nikolich-Zugich, Janko, Shlomchik, Mark J., Satpathy, Ansuman T., Fremont, Daved H., Diamond, Michael S., Bhattacharya, Deepta

“…Memory B cells (MBCs) can respond to heterologous antigens either by molding new specificities through secondary germinal centers (GCs) or by selecting…”
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Author Correction: Engineering circular RNA for enhanced protein production by Chen, Robert, Wang, Sean K., Belk, Julia A., Amaya, Laura, Li, Zhijian, Cardenas, Angel, Abe, Brian T., Chen, Chun-Kan, Wender, Paul A., Chang, Howard Y.

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Epigenetic regulation of T cell exhaustion by Belk, Julia A., Daniel, Bence, Satpathy, Ansuman T.

“…Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion, which is characterized by reduced effector function and…”
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Engineering circular RNA for enhanced protein production by Chen, Robert, Wang, Sean K., Belk, Julia A., Amaya, Laura, Li, Zhijian, Cardenas, Angel, Abe, Brian T., Chen, Chun-Kan, Wender, Paul A., Chang, Howard Y.

“…Circular RNAs (circRNAs) are stable and prevalent RNAs in eukaryotic cells that arise from back-splicing. Synthetic circRNAs and some endogenous circRNAs can…”
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Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling by Weber, Evan W, Parker, Kevin R, Sotillo, Elena, Lynn, Rachel C, Anbunathan, Hima, Lattin, John, Good, Zinaida, Belk, Julia A, Daniel, Bence, Klysz, Dorota, Malipatlolla, Meena, Xu, Peng, Bashti, Malek, Heitzeneder, Sabine, Labanieh, Louai, Vandris, Panayiotis, Majzner, Robbie G, Qi, Yanyan, Sandor, Katalin, Chen, Ling-Chun, Prabhu, Snehit, Gentles, Andrew J, Wandless, Thomas J, Satpathy, Ansuman T, Chang, Howard Y, Mackall, Crystal L

“…T cell exhaustion limits immune responses against cancer and is a major cause of resistance to chimeric antigen receptor (CAR)-T cell therapeutics. Using…”
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Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence by Belk, Julia A., Yao, Winnie, Ly, Nghi, Freitas, Katherine A., Chen, Yan-Ting, Shi, Quanming, Valencia, Alfredo M., Shifrut, Eric, Kale, Nupura, Yost, Kathryn E., Duffy, Connor V., Daniel, Bence, Hwee, Madeline A., Miao, Zhuang, Ashworth, Alan, Mackall, Crystal L., Marson, Alexander, Carnevale, Julia, Vardhana, Santosh A., Satpathy, Ansuman T.

“…T cell exhaustion limits antitumor immunity, but the molecular determinants of this process remain poorly understood. Using a chronic stimulation assay, we…”
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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis by Reticker-Flynn, Nathan E., Zhang, Weiruo, Belk, Julia A., Basto, Pamela A., Escalante, Nichole K., Pilarowski, Genay O.W., Bejnood, Alborz, Martins, Maria M., Kenkel, Justin A., Linde, Ian L., Bagchi, Sreya, Yuan, Robert, Chang, Serena, Spitzer, Matthew H., Carmi, Yaron, Cheng, Jiahan, Tolentino, Lorna L., Choi, Okmi, Wu, Nancy, Kong, Christina S., Gentles, Andrew J., Sunwoo, John B., Satpathy, Ansuman T., Plevritis, Sylvia K., Engleman, Edgar G.

“…For many solid malignancies, lymph node (LN) involvement represents a harbinger of distant metastatic disease and, therefore, an important prognostic factor…”
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Divergent clonal differentiation trajectories of T cell exhaustion by Daniel, Bence, Yost, Kathryn E., Hsiung, Sunnie, Sandor, Katalin, Xia, Yu, Qi, Yanyan, Hiam-Galvez, Kamir J., Black, Mollie, J. Raposo, Colin, Shi, Quanming, Meier, Stefanie L., Belk, Julia A., Giles, Josephine R., Wherry, E. John, Chang, Howard Y., Egawa, Takeshi, Satpathy, Ansuman T.

“…Chronic antigen exposure during viral infection or cancer promotes an exhausted T cell (Tex) state with reduced effector function. However, whether all…”
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ecDNA hubs drive cooperative intermolecular oncogene expression by Hung, King L., Yost, Kathryn E., Xie, Liangqi, Shi, Quanming, Helmsauer, Konstantin, Luebeck, Jens, Schöpflin, Robert, Lange, Joshua T., Chamorro González, Rocío, Weiser, Natasha E., Chen, Celine, Valieva, Maria E., Wong, Ivy Tsz-Lo, Wu, Sihan, Dehkordi, Siavash R., Duffy, Connor V., Kraft, Katerina, Tang, Jun, Belk, Julia A., Rose, John C., Corces, M. Ryan, Granja, Jeffrey M., Li, Rui, Rajkumar, Utkrisht, Friedlein, Jordan, Bagchi, Anindya, Satpathy, Ansuman T., Tjian, Robert, Mundlos, Stefan, Bafna, Vineet, Henssen, Anton G., Mischel, Paul S., Liu, Zhe, Chang, Howard Y.

“…Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation 1 …”
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Xist ribonucleoproteins promote female sex-biased autoimmunity by Dou, Diana R, Zhao, Yanding, Belk, Julia A, Zhao, Yang, Casey, Kerriann M, Chen, Derek C, Li, Rui, Yu, Bingfei, Srinivasan, Suhas, Abe, Brian T, Kraft, Katerina, Hellström, Ceke, Sjöberg, Ronald, Chang, Sarah, Feng, Allan, Goldman, Daniel W, Shah, Ami A, Petri, Michelle, Chung, Lorinda S, Fiorentino, David F, Lundberg, Emma K, Wutz, Anton, Utz, Paul J, Chang, Howard Y

“…Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to…”
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Enhanced T cell effector activity by targeting the Mediator kinase module by Freitas, Katherine A, Belk, Julia A, Sotillo, Elena, Quinn, Patrick J, Ramello, Maria C, Malipatlolla, Meena, Daniel, Bence, Sandor, Katalin, Klysz, Dorota, Bjelajac, Jeremy, Xu, Peng, Burdsall, Kylie A, Tieu, Victor, Duong, Vandon T, Donovan, Micah G, Weber, Evan W, Chang, Howard Y, Majzner, Robbie G, Espinosa, Joaquin M, Satpathy, Ansuman T, Mackall, Crystal L

“…T cells are the major arm of the immune system responsible for controlling and regressing cancers. To identify genes limiting T cell function, we conducted…”
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Engineered cell entry links receptor biology with single-cell genomics by Yu, Bingfei, Shi, Quanming, Belk, Julia A., Yost, Kathryn E., Parker, Kevin R., Li, Rui, Liu, Betty B., Huang, Huang, Lingwood, Daniel, Greenleaf, William J., Davis, Mark M., Satpathy, Ansuman T., Chang, Howard Y.

“…Cells communicate with each other via receptor-ligand interactions. Here, we describe lentiviral-mediated cell entry by engineered receptor-ligand interaction…”
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Bidirectional epigenetic editing reveals hierarchies in gene regulation by Pacalin, Naomi M, Steinhart, Zachary, Shi, Quanming, Belk, Julia A, Dorovskyi, Dmytro, Kraft, Katerina, Parker, Kevin R, Shy, Brian R, Marson, Alexander, Chang, Howard Y

“…CRISPR perturbation methods are limited in their ability to study non-coding elements and genetic interactions. In this study, we developed a system for…”
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Clonal hematopoiesis is associated with protection from Alzheimer’s disease by Bouzid, Hind, Belk, Julia A., Jan, Max, Qi, Yanyan, Sarnowski, Chloé, Wirth, Sara, Ma, Lisa, Chrostek, Matthew R., Ahmad, Herra, Nachun, Daniel, Yao, Winnie, Beiser, Alexa, Bick, Alexander G., Bis, Joshua C., Fornage, Myriam, Longstreth, William T., Lopez, Oscar L., Natarajan, Pradeep, Psaty, Bruce M., Satizabal, Claudia L., Weinstock, Joshua, Larson, Eric B., Crane, Paul K., Keene, C. Dirk, Seshadri, Sudha, Satpathy, Ansuman T., Montine, Thomas J., Jaiswal, Siddhartha

“…Clonal hematopoiesis of indeterminate potential (CHIP) is a premalignant expansion of mutated hematopoietic stem cells. As CHIP-associated mutations are known…”
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A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance by Warshauer, Jeremy T, Belk, Julia A, Chan, Alice Y, Wang, Jiaxi, Gupta, Alexander R, Shi, Quanming, Skartsis, Nikolaos, Peng, Yani, Phipps, Jonah D, Acenas, Dante, Smith, Jennifer A, Tamaki, Stanley J, Tang, Qizhi, Gardner, James M, Satpathy, Ansuman T, Anderson, Mark S

“…Naturally occurring cases of monogenic type 1 diabetes (T1D) help establish direct mechanisms driving this complex autoimmune disease. A recently identified de…”
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Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection by Biering, Scott B., Sarnik, Sylvia A., Wang, Eleanor, Zengel, James R., Leist, Sarah R., Schäfer, Alexandra, Sathyan, Varun, Hawkins, Padraig, Okuda, Kenichi, Tau, Cyrus, Jangid, Aditya R., Duffy, Connor V., Wei, Jin, Gilmore, Rodney C., Alfajaro, Mia Madel, Strine, Madison S., Nguyenla, Xammy, Van Dis, Erik, Catamura, Carmelle, Yamashiro, Livia H., Belk, Julia A., Begeman, Adam, Stark, Jessica C., Shon, D. Judy, Fox, Douglas M., Ezzatpour, Shahrzad, Huang, Emily, Olegario, Nico, Rustagi, Arjun, Volmer, Allison S., Livraghi-Butrico, Alessandra, Wehri, Eddie, Behringer, Richard R., Cheon, Dong-Joo, Schaletzky, Julia, Aguilar, Hector C., Puschnik, Andreas S., Button, Brian, Pinsky, Benjamin A., Blish, Catherine A., Baric, Ralph S., O’Neal, Wanda K., Bertozzi, Carolyn R., Wilen, Craig B., Boucher, Richard C., Carette, Jan E., Stanley, Sarah A., Harris, Eva, Konermann, Silvana, Hsu, Patrick D.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute…”
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Leveraging nonstructural data to predict structures and affinities of protein–ligand complexes by Paggi, Joseph M., Belk, Julia A., Hollingsworth, Scott A., Villanueva, Nicolas, Powers, Alexander S., Clark, Mary J., Chemparathy, Augustine G., Tynan, Jonathan E., Lau, Thomas K., Sunahara, Roger K., Dror, Ron O.

“…Over the past five decades, tremendous effort has been devoted to computational methods for predicting properties of ligands—i.e., molecules that bind…”
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A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages by Brioschi, Simone, Belk, Julia A., Peng, Vincent, Molgora, Martina, Rodrigues, Patrick Fernandes, Nguyen, Khai M., Wang, Shoutang, Du, Siling, Wang, Wei-Le, Grajales-Reyes, Gary E., Ponce, Jennifer M., Yuede, Carla M., Li, Qingyun, Baer, John M., DeNardo, David G., Gilfillan, Susan, Cella, Marina, Satpathy, Ansuman T., Colonna, Marco

“…Genetic tools to target microglia specifically and efficiently from the early stages of embryonic development are lacking. We generated a constitutive Cre line…”
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