Search Results - "Belizaire, Roger"

Targeting Proteins to Distinct Subcellular Compartments Reveals Unique Requirements for MHC Class I and II Presentation by Belizaire, Roger, Unanue, Emil R.

“…Peptides derived from exogenous proteins are presented by both MHC class I and II. Despite extensive study, the features of the endocytic pathway that mediate…”
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Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia by Tothova, Zuzana, Krill-Burger, John M., Popova, Katerina D., Landers, Catherine C., Sievers, Quinlan L., Yudovich, David, Belizaire, Roger, Aster, Jon C., Morgan, Elizabeth A., Tsherniak, Aviad, Ebert, Benjamin L.

“…Hematologic malignancies are driven by combinations of genetic lesions that have been difficult to model in human cells. We used CRISPR/Cas9 genome engineering…”
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Altered Proteasomal Function in Sporadic Parkinson's Disease by St. P. McNaught, Kevin, Belizaire, Roger, Isacson, Ole, Jenner, Peter, Olanow, C.Warren

“…Parkinson's disease (PD) is characterized pathologically by preferential degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNc)…”
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Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease by Belizaire, Roger, Kim, Haesook T., Poryanda, Samuel J., Mirkovic, Nikola V., Hipolito, Evelyn, Savage, William J., Reynolds, Carol G., Fields, Marie J., Whangbo, Jennifer, Kubo, Tomohiro, Nikiforow, Sarah, Alyea, Edwin P., Armand, Philippe, Cutler, Corey S., Ho, Vincent T., Blazar, Bruce R., Antin, Joseph H., Ritz, Jerome, Soiffer, Robert J., Koreth, John

“…Chronic graft-versus-host disease (cGVHD) affects >50% of hematopoietic stem cell transplant patients. Extracorporeal photopheresis (ECP), an immunomodulatory…”
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Clonal Hematopoiesis and CKD Progression by Niroula, Abhishek, Belizaire, Roger

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SV2B Regulates Synaptotagmin 1 by Direct Interaction by Lazzell, Diana R, Belizaire, Roger, Thakur, Pratima, Sherry, David M, Janz, Roger

“…SV2 proteins are abundant synaptic vesicle proteins expressed in two major (SV2A and SV2B) and one minor (SV2C) isoform. SV2A and SV2B have been shown to be…”
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Characterization of synaptogyrin 3 as a new synaptic vesicle protein by Belizaire, Roger, Komanduri, Cheryl, Wooten, Kerry, Chen, Ming, Thaller, Christina, Janz, Roger

“…Synaptogyrins comprise a family of tyrosine‐phosphorylated proteins with two neuronal (synaptogyrins 1 and 3) and one ubiquitous (cellugyrin) isoform. Previous…”
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Clonal haematopoiesis and dysregulation of the immune system by Belizaire, Roger, Wong, Waihay J., Robinette, Michelle L., Ebert, Benjamin L.

“…Age-related diseases are frequently linked to pathological immune dysfunction, including excessive inflammation, autoreactivity and immunodeficiency. Recent…”
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To Fe, or not to Fe, that is the question by Belizaire, Roger, Stowell, Sean R.

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Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing by Heckl, Dirk, Kowalczyk, Monika S, Yudovich, David, Belizaire, Roger, Puram, Rishi V, McConkey, Marie E, Thielke, Anne, Aster, Jon C, Regev, Aviv, Ebert, Benjamin L

“…The genetic complexity of human leukemia is modeled using the CRISPR-Cas9 system in mice. Genome sequencing studies have shown that human malignancies often…”
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Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion by Belizaire, Roger, Makar, Robert S

“…Refractoriness to platelet transfusion is a common clinical problem encountered by the transfusion medicine specialist. It is well recognized that most causes…”
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Sensitivity to Targeted UBA1 Inhibition in a Myeloid Cell Line Model of Vexas Syndrome by Chiaramida, Adriana, Obwar, Sandra G., Griffin, Gabriel K., Nordstrom, Anja E.H., Ericsson, Maria, Khan, Dilshad H., Belizaire, Roger

“…Somatic UBA1 mutations in hematopoietic cells are a hallmark of VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome, which is a…”
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Red blood cell alloantibodies are associated with increased alloimmunization against human leukocyte antigens by Belizaire, Roger, Mack, Johnathan, Kadauke, Stephan, Kim, Yeowon, Saidman, Susan, Makar, Robert S.

“…BACKGROUND Alloantibodies recognizing human leukocyte antigens (HLA) can cause immune‐mediated refractoriness to platelet transfusion. An association between…”
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A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability by Koochaki, Sebastian H.J., Słabicki, Mikołaj, Lumpkin, Ryan, Zou, Charles, Belizaire, Roger, Fischer, Eric S., Ebert, Benjamin L.

“…The IL-3, IL-5, and GM-CSF family of cytokines play an essential role in the growth, differentiation, and effector functions of multiple hematopoietic cell…”
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CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1 by Belizaire, Roger, Koochaki, Sebastian H.J., Udeshi, Namrata D., Vedder, Alexis, Sun, Lei, Svinkina, Tanya, Hartigan, Christina, McConkey, Marie, Kovalcik, Veronica, Bizuayehu, Amanuel, Stanclift, Caroline, Schenone, Monica, Carr, Steven A., Padron, Eric, Ebert, Benjamin L.

“…Casitas B-lineage lymphoma (CBL) encodes an E3 ubiquitin ligase and signaling adaptor that regulates receptor and nonreceptor tyrosine kinases. Recurrent CBL…”
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Splicing Modulators Impair DNA Damage Response and Induce Killing of Cohesin-Mutant MDS/AML by Wheeler, Emily C, Martin, Benjamin, Doyle, William, Gorelov, Rebecca, Donahue, Melanie, Jann, Johann-Christoph, Abdel-Wahab, Omar, Taylor, Justin, Seiler, Michael, Buonamici, Silvia, Belizaire, Roger, Adelman, Karen, Tothova, Zuzana

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Oncogenic Mechanisms of CBL E3 Ubiquitin Ligase Mutations in Myeloid Malignancies by Belizaire, Roger, Koochaki, Sebastian, Udeshi, Namrata, Vedder, Alexis, Sun, Lei, Schenone, Monica, Carr, Steven, Padron, Eric, Ebert, Benjamin L.

“…CBL encodes an E3 ubiquitin ligase and signaling adaptor that acts downstream of cytokine receptors. Recurrent CBL mutations are found in a variety of myeloid…”
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UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability by Tsai, Jonathan M, Aguirre, Jacob D, Li, Yen-Der, Brown, Jared, Focht, Vivian, Kater, Lukas, Kempf, Georg, Sandoval, Brittany, Schmitt, Stefan, Rutter, Justine C, Galli, Pius, Sandate, Colby R, Cutler, Jevon A, Zou, Charles, Donovan, Katherine A, Lumpkin, Ryan J, Cavadini, Simone, Park, Paul M C, Sievers, Quinlan, Hatton, Charlie, Ener, Elizabeth, Regalado, Brandon D, Sperling, Micah T, Słabicki, Mikołaj, Kim, Jeonghyeon, Zon, Rebecca, Zhang, Zinan, Miller, Peter G, Belizaire, Roger, Sperling, Adam S, Fischer, Eric S, Irizarry, Rafael, Armstrong, Scott A, Thomä, Nicolas H, Ebert, Benjamin L

“…Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely targeted therapeutically. Agonist binding triggers NR activation and…”
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Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML by Wheeler, Emily C, Martin, Benjamin J E, Doyle, William C, Neaher, Sofia, Conway, Caroline A, Pitton, Caroline N, Gorelov, Rebecca A, Donahue, Melanie, Jann, Johann C, Abdel-Wahab, Omar, Taylor, Justin, Seiler, Michael, Buonamici, Silvia, Pikman, Yana, Garcia, Jacqueline S, Belizaire, Roger, Adelman, Karen, Tothova, Zuzana

“…Splicing modulation is a promising treatment strategy pursued to date only in splicing factor-mutant cancers; however, its therapeutic potential is poorly…”
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Salt Accelerates Allograft Rejection through Serum- and Glucocorticoid-Regulated Kinase-1-Dependent Inhibition of Regulatory T Cells by Safa, Kassem, Ohori, Shunsuke, Borges, Thiago J, Uehara, Mayuko, Batal, Ibrahim, Shimizu, Tetsunosuke, Magee, Ciara N, Belizaire, Roger, Abdi, Reza, Wu, Chuan, Chandraker, Anil, Riella, Leonardo V

“…A high-salt diet (HSD) in humans is linked to a number of complications, including hypertension and cardiovascular events. Whether a HSD affects the immune…”
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