Search Results - "Belinsky, Martin"

Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study by von Mehren, Margaret, George, Suzanne, Heinrich, Michael C, Schuetze, Scott M, Yap, Jeffrey T, Yu, Jain Q, Abbott, Amanda, Litwin, Samuel, Crowley, John, Belinsky, Martin, Janeway, Katherine A, Hornick, Jason L, Flieder, Douglas B, Chugh, Rashmi, Rink, Lori, Van den Abbeele, Annick D

“…Most gastrointestinal stromal tumors (GIST) have activating mutations of , or uncommonly . Fifteen percent of adult and 85% of pediatric GISTs are wild type…”
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The MRP family of drug efflux pumps by Kruh, Gary D, Belinsky, Martin G

“…The MRP family is comprised of nine related ABC transporters that are able to transport structurally diverse lipophilic anions and function as drug efflux…”
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organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis by Rao, Anuradha, Haywood, Jamie, Craddock, Ann L, Belinsky, Martin G, Kruh, Gary D, Dawson, Paul A

“…The apical sodium-dependent bile acid transporter (Asbt) is responsible for transport across the intestinal brush border membrane; however, the carrier(s)…”
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Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor by Zook, Phillip, Pathak, Harsh B, Belinsky, Martin G, Gersz, Lawrence, Devarajan, Karthik, Zhou, Yan, Godwin, Andrew K, von Mehren, Margaret, Rink, Lori

“…Gastrointestinal stromal tumors (GIST) generally harbor activating mutations in the receptor tyrosine kinase KIT or in the related platelet-derived growth…”
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Succinate dehydrogenase deficiency in a PDGFRA mutated GIST by Belinsky, Martin G, Cai, Kathy Q, Zhou, Yan, Luo, Biao, Pei, Jianming, Rink, Lori, von Mehren, Margaret

“…Most gastrointestinal stromal tumors (GISTs) harbor mutually exclusive gain of function mutations in the receptor tyrosine kinase (RTK) KIT (70-80%) or in the…”
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Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors by Belinsky, Martin G, Rink, Lori, von Mehren, Margaret

“…Gastrointestinal stromal tumors (GISTs) in adults are generally driven by somatic gain-of-function mutations in KIT or PDGFRA, and biological therapies…”
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Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors by Belinsky, Martin G., Rink, Lori, Flieder, Douglas B., Jahromi, Mona S., Schiffman, Joshua D., Godwin, Andrew K., Mehren, Margaret von

“…Approximately 15% of gastrointestinal stromal tumors (GISTs) in adults and 85% in children lack mutations in KIT and PDGFRA and are known as wild‐type GISTs…”
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ABCC10, ABCC11, and ABCC12 by Kruh, Gary D, Guo, Yanping, Hopper-Borge, Elizabeth, Belinsky, Martin G, Chen, Zhe-Sheng

“…Multidrug resistance protein (MRP)7, MRP8, and MRP9 (gene symbols ABCC10, ABCC11, and ABCC12) are recently identified members of the MRP family that are at…”
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Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case by Belinsky, Martin G, Rink, Lori, Cai, Kathy Q, Capuzzi, Stephen J, Hoang, Yen, Chien, Jeremy, Godwin, Andrew K, von Mehren, Margaret

“…Approximately 10-15 % of gastrointestinal stromal tumors (GISTs) lack gain of function mutations in the KIT and platelet-derived growth factor receptor alpha…”
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MRP8, ATP-binding Cassette C11 (ABCC11), Is a Cyclic Nucleotide Efflux Pump and a Resistance Factor for Fluoropyrimidines 2′,3′-Dideoxycytidine and 9′-(2′-Phosphonylmethoxyethyl)adenine by Guo, Yanping, Kotova, Elena, Chen, Zhe-Sheng, Lee, Kun, Hopper-Borge, Elizabeth, Belinsky, Martin G., Kruh, Gary D.

“…MRP8 (ABCC11) is a recently identified cDNA that has been assigned to the multidrug resistance-associated protein (MRP) family of ATP-binding cassette…”
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Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): Resistance to docetaxel by HOPPER-BORGE, Elizabeth, CHEN, Zhe-Sheng, SHCHAVELEVA, Irina, BELINSKY, Martin G, KRUH, Gary D

“…The multidrug resistance protein (MRP) family consists of nine members that can be categorized according to whether or not a third (NH(2)-terminal)…”
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Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10-/- Mice by HOPPER-BORGE, Elizabeth A, CHURCHILL, Timothy, KLEIN-SZANTO, Andres J, BELINSKY, Martin G, KRUH, Gary D, PAULOSE, Chelsy, NICOLAS, Emmanuelle, JACOBS, Joely D, NGO, Olivia, YEHONG KUANG, GRINBERG, Alex, WESTPHAL, Heiner, CHEN, Zhe-Sheng

“…Recently, we reported that the ATP-binding cassette transporter 10 (ABCC10), also known as multidrug resistance protein 7 (MRP7), is able to confer resistance…”
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Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6) by BELINSKY, Martin G, CHEN, Zhe-Sheng, SHCHAVELEVA, Irina, HAO ZENG, KRUH, Gary D

“…Mutations in human multidrug resistance protein 6 (MRP6, ABCC6), a member of the MRP family of drug efflux pumps, are the genetic basis of Pseudoxanthoma…”
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Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice by Kruh, Gary D, Belinsky, Martin G, Gallo, James M, Lee, Kun

“…The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of conferring resistance to various…”
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Transport of methotrexate, methotrexate polyglutamates, and 17β-estradiol 17-(β-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport by CHEN, Zhe-Sheng, ROBEY, Robert W, BELINSKY, Martin G, SHCHAVELEVA, Irina, REN, Xiao-Qin, SUGIMOTO, Yoshikazu, ROSS, Douglas D, BATES, Susan E, KRUH, Gary D

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Analysis of the in vivo functions of Mrp3 by Belinsky, Martin G, Dawson, Paul A, Shchaveleva, Irina, Bain, Lisa J, Wang, Renxue, Ling, Victor, Chen, Zhe-Sheng, Grinberg, Alex, Westphal, Heiner, Klein-Szanto, Andres, Lerro, Anthony, Kruh, Gary D

“…Multidrug resistance protein 3 (MRP3) is an ATP-binding cassette transporter that is able to confer resistance to anticancer agents such as etoposide and to…”
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Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor by Kozinova, Marya, Joshi, Shalina, Ye, Shuai, Belinsky, Martin G, Sharipova, Dinara, Farma, Jeffrey M, Reddy, Sanjay S, Litwin, Samuel, Devarajan, Karthik, Campos, Alex Rosa, Yu, Yi, Schwartz, Brian, von Mehren, Margaret, Rink, Lori

“…The majority of gastrointestinal stromal tumor (GIST) patients develop resistance to the first-line KIT inhibitor, imatinib mesylate (IM), through acquisition…”
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Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11) by Chen, Zhe-Sheng, Guo, Yanping, Belinsky, Martin G, Kotova, Elena, Kruh, Gary D

“…We previously determined that expression of human multidrug resistance protein (MRP) 8, a recently described member of the MRP family of ATP-binding cassette…”
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Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10) by Chen, Zhe-Sheng, Hopper-Borge, Elizabeth, Belinsky, Martin G, Shchaveleva, Irina, Kotova, Elena, Kruh, Gary D

“…Human multidrug resistance protein 7 (MRP7, ABCC10) is a recently described member of the C family of ATP binding cassette proteins (Cancer Lett 162:181-191,…”
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Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor by Rink, Lori, Skorobogatko, Yuliya, Kossenkov, Andrew V, Belinsky, Martin G, Pajak, Thomas, Heinrich, Michael C, Blanke, Charles D, von Mehren, Margaret, Ochs, Michael F, Eisenberg, Burton, Godwin, Andrew K

“…Despite initial efficacy of imatinib mesylate in most gastrointestinal stromal tumor (GIST) patients, many experience primary/secondary drug resistance…”
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