Search Results - "Belinsky, Glenn S"

Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex by Moore, Anna R, Zhou, Wen-Liang, Sirois, Carissa L, Belinsky, Glenn S, Zecevic, Nada, Antic, Srdjan D

“…Significance Young neurons require occasional bursts of action-potential firing to maintain intracellular processes, to drive gene expression, to indicate…”
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Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis by Nakanishi, Masako, Montrose, David C, Clark, Patsy, Nambiar, Prashant R, Belinsky, Glenn S, Claffey, Kevin P, Xu, Daigen, Rosenberg, Daniel W

“…Elevated levels of prostaglandin E(2) (PGE(2)) are often found in colorectal cancers. Thus, nonsteroidal anti-inflammatory drugs, including selective…”
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Mild hypothermia inhibits differentiation of human embryonic and induced pluripotent stem cells by Belinsky, Glenn S, Antic, Srdjan D

“…Culture of pluripotent stem cells at 35°C strikingly reduces unwanted spontaneous differentiation during hESC and iPSC maintenance compared with 37°C. Growth…”
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Patch-clamp recordings and calcium imaging followed by single-cell PCR reveal the developmental profile of 13 genes in iPSC-derived human neurons by Belinsky, Glenn S., Rich, Matthew T., Sirois, Carissa L., Short, Shaina M., Pedrosa, Erika, Lachman, Herbert M., Antic, Srdjan D.

“…Molecular genetic studies are typically performed on homogenized biological samples, resulting in contamination from non-neuronal cells. To improve expression…”
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Physiological properties of neurons derived from human embryonic stem cells using a dibutyryl cyclic AMP-based protocol by Belinsky, Glenn S, Moore, Anna R, Short, Shaina M, Rich, Matthew T, Antic, Srdjan D

“…Neurons derived from human embryonic stem cells hold promise for the therapy of neurological diseases. Quality inspection of human embryonic stem cell-derived…”
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Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis by ILSLEY, Jillian N. M, NAKANISHI, Masako, FLYNN, Christopher, BELINSKY, Glenn S, DE GUISE, Sylvain, ADIB, John N, DOBROWSKY, Rick T, BONVENTRE, Joseph V, ROSENBERG, Daniel W

“…Cellular pools of free arachidonic acid are tightly controlled through enzymatic release of the fatty acid and subsequent utilization by downstream enzymes…”
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Pigment epithelium‐derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade by Belinsky, Glenn S., Sreekumar, Bharath, Andrejecsk, Jillian W., Saltzman, W. Mark, Gong, Jingjing, Herzog, Raimund I., Lin, Samantha, Horsley, Valerie, Carpenter, Thomas O., Chung, Chuhan

“…ABSTRACT Null mutations in for pigment epithelium‐derived factor (PEDF), the protein product of the SERPINF1 gene, are the cause of osteogenesis imperfecta…”
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DNA damage response to the Mdm2 inhibitor Nutlin-3 by Verma, Rajeev, Rigatti, Marc J., Belinsky, Glenn S., Godman, Cassandra A., Giardina, Charles

“…Mdm2 inhibitors represent a promising class of p53 activating compounds that may be useful in cancer treatment and prevention. However, the consequences of…”
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Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells by Rigatti, Marc J., Verma, Rajeev, Belinsky, Glenn S., Rosenberg, Daniel W., Giardina, Charles

“…The p53 tumor suppressor protein performs a number of cellular functions, ranging from the induction of cell cycle arrest and apoptosis to effects on DNA…”
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Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver by Protiva, Petr, Gong, Jingjing, Sreekumar, Bharath, Torres, Richard, Zhang, Xuchen, Belinsky, Glenn S, Cornwell, Mona, Crawford, Susan E, Iwakiri, Yasuko, Chung, Chuhan

“…Background & Aims Pigment epithelium-derived factor (PEDF) is a secretory protein that inhibits multiple tumor types. PEDF inhibits the Wnt coreceptor,…”
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Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI by Belinsky, Glenn S., Ward, Leanne, Chung, Chuhan

“…Osteogenesis imperfecta (OI) Type VI is characterized by a defect in bone mineralization, which results in multiple fractures early in life. Null mutations in…”
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Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions by Sreekumar, Bharath K, Belinsky, Glenn S, Einwachter, Henrik, Rhim, Andrew D, Schmid, Roland, Chung, Chuhan

“…A functional vacuolar adenosine triphosphatase (v-ATPase) complex regulates canonical Wnt/β-catenin signaling. The goal of this study was to identify the…”
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Dopamine receptors in human embryonic stem cell neurodifferentiation by Belinsky, Glenn S, Sirois, Carissa L, Rich, Matthew T, Short, Shaina M, Moore, Anna R, Gilbert, Sarah E, Antic, Srdjan D

“…We tested whether dopaminergic drugs can improve the protocol for in vitro differentiation of H9 human embryonic stem cells (hESCs) into dopaminergic neurons…”
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cPLA2 Is Protective Against COX Inhibitor–Induced Intestinal Damage by Montrose, David C., Kadaveru, Krishna, Ilsley, Jillian N. M., Root, Sierra H., Rajan, Thiruchanduri V., Ramesh, Manish, Nichols, Frank C., Liang, Bruce T., Sonin, Dmitry, Hand, Arthur R., Zarini, Simona, Murphy, Robert C., Belinsky, Glenn S., Nakanishi, Masako, Rosenberg, Daniel W.

“…Cytosolic phospholipase A2 (cPLA2) is the rate-limiting enzyme responsible for the generation of prostaglandins (PGs), which are bioactive lipids that play…”
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Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth by Belinsky, Glenn S., Rajan, Thiruchandurai V., Saria, Elizabeth A., Giardina, Charles, Rosenberg, Daniel W.

“…Secretory phospholipase A2 (sPLA2‐IIA) has been shown to attenuate intestinal tumorigenesis in ApcMin mice, demonstrating that it is a tumor modifier. To…”
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Epigenetic alterations in RASSF1A in human aberrant crypt foci by Greenspan, Emily J., Jablonski, Melissa A., Rajan, Thiruchandurai V., Levine, Joel, Belinsky, Glenn S., Rosenberg, Daniel W.

“…CpG island methylation (CIM) is an epigenetic mechanism for transcriptional silencing that occurs at various stages of colon tumorigenesis. CIM has been found…”
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Inverse association between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis by Dong, Mei, Guda, Kishore, Nambiar, Prashant R., Rezaie, Anahita, Belinsky, Glenn S., Lambeau, Gérard, Giardina, Charles, Rosenberg, Daniel W.

“…Cytosolic phospholipase A2 (cPLA2) releases arachidonic acid (AA) from intracellular phospholipids. We evaluated the status of cPLA2 in azoxymethane…”
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The Contribution of Methotrexate Exposure and Host Factors on Transcriptional Variance in Human Liver by Belinsky, Glenn S., Parke, Ann L., Huang, Qihong, Blanchard, Kerry, Jayadev, Supriya, Stoll, Raymond, Rothe, Marti, Achenie, Luke E. K., Gupta, Rishi R., Wu, George Y., Rosenberg, Daniel W.

“…Long-term administration of methotrexate (MTX) for management of chronic inflammatory diseases is associated with risk of liver damage. In this study, we…”
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Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors by Aizu, Wataru, Belinsky, Glenn S., Flynn, Christopher, Noonan, Emily J., Boes, Colleen C., Godman, Cassandra A., Doshi, Bindi, Nambiar, Prashant R., Rosenberg, Daniel W., Giardina, Charles

“…The p53 tumor suppressor protein is sequence-normal in azoxymethane (AOM)-induced mouse colon tumors, making them a good model for human colon cancers that…”
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Dietary iron promotes azoxymethane-induced colon tumors in mice by Ilsley, J.N.M, Belinsky, G.S, Guda, K, Zhang, Q, Huang, X, Blumberg, J.B, Millbury, P.E, Roberts, L.J. II, Stevens, R.G, Rosenberg, D.W

“…There is accumulating evidence that high levels of dietary iron may play a role in colon carcinogenesis. We used a mouse model to investigate the impact of…”
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