Development of an injectable composite for bone regeneration

Abstract With the development of minimally invasive surgical techniques, there is a growing interest in the research and development of injectable biomaterials especially for orthopedic applications. In a view to enhance the overall surgery benefits for the patient, the BIOSINJECT project aims at pr...

Full description

Saved in:

Bibliographic Details
Published in:	Ingénierie et recherche biomédicale Vol. 34; no. 2; pp. 176 - 179
Main Authors:	Jacquart, S, Belime, A, Pigasse, C, Siadous, R, Fatnassi, M, Tadier, S, Auzély-Velty, R, Girod-Fullana, S, Bareille, R, Roques, C, El Kissi, N, Anagnostou, F, Bignon, A, Cordier, D, Rey, C, Brouillet, F, Amédée, J, Galliard, H, Combes, C
Format:	Journal Article
Language:	English
Published:	Elsevier Masson SAS 01-04-2013 Elsevier Masson
Subjects:	Engineering Sciences Internal Medicine Materials Micro and nanotechnologies Microelectronics Calcium carbonate-calcium phosphate Composite Bone regeneration Cement
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract With the development of minimally invasive surgical techniques, there is a growing interest in the research and development of injectable biomaterials especially for orthopedic applications. In a view to enhance the overall surgery benefits for the patient, the BIOSINJECT project aims at preparing a new generation of mineral-organic composites for bone regeneration exhibiting bioactivity, therapeutic activity and easiness of use to broaden the application domains of the actual bone mineral cements and propose an alternative strategy with regard to their poor resorbability, injectability difficulties and risk of infection. First, a physical-chemical study demonstrated the feasibility of self-setting injectable composites associating calcium carbonate-calcium phosphate cement and polysaccharides (tailor-made or commercial polymer) in the presence or not of an antibacterial agent within the composite formulation. Then, bone cell response and antimicrobial activity of the composite have been evaluated in vitro. Finally, in order to evaluate resorption rate and bone tissue response an animal study has been performed and the histological analysis is still in progress. These multidisciplinary and complementary studies led to promising results in a view of the industrial development of such composite for dental and orthopaedic applications.
ISSN:	1959-0318
DOI:	10.1016/j.irbm.2013.01.008