Search Results - "Beletskaya, Irina O."

Structure activity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: Preliminary results on the role of electronic characteristics for affinity and function by Yuan, Yunyun, Elbegdorj, Orgil, Beletskaya, Irina O., Selley, Dana E., Zhang, Yan

“…NAQ analogues. 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan (NAQ) was previously designed following the…”
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Design, Synthesis, and Biological Evaluation of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan Derivatives as Peripheral Selective μ Opioid Receptor Agents by Yuan, Yunyun, Elbegdorj, Orgil, Chen, Jianyang, Akubathini, Shashidhar K, Zhang, Feng, Stevens, David L, Beletskaya, Irina O, Scoggins, Krista L, Zhang, Zhenxian, Gerk, Phillip M, Selley, Dana E, Akbarali, Hamid I, Dewey, William L, Zhang, Yan

“…Peripheral selective μ opioid receptor (MOR) antagonists could alleviate the symptoms of opioid-induced constipation (OIC) without compromising the analgesic…”
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Opioid receptor selectivity profile change via isosterism for 14-O-substituted naltrexone derivatives by Zhang, Yan, Elbegdorj, Orgil, Yuan, Yunyun, Beletskaya, Irina O., Selley, Dana E.

“…Isosterism is commonly used in drug discovery and development to address stability, selectivity, toxicity, pharmacokinetics, and efficacy issues. A series of…”
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Structure selectivity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan derivatives toward the development of the mu opioid receptor antagonists by Yuan, Yunyun, Elbegdorj, Orgil, Chen, Jianyang, Akubathini, Shashidhar K., Beletskaya, Irina O., Selley, Dana E., Zhang, Yan

“…Mu opioid receptor antagonists have been applied to target a variety of diseases clinically. The current study is designed to explore the structure selectivity…”
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Opioid receptor selectivity profile change via isosterism for 14-O-substitued naltrexone derivatives by Zhang, Yan, Elbegdorj, Orgil, Yuan, Yunyun, Beletskaya, Irina O., Selley, Dana E.

“…Isosterism is commonly used in drug discovery and development to address stability, selectivity, toxicity, pharmacokinetics, and efficacy issues. A series of…”
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Structure selectivity relationship studies of 17-cyclopropylmethyl-3,14[beta]-dihydroxy-4,5[alpha]-epoxy-6[beta] - [(4'-pyridyl)carboxamido]morphinan derivatives toward the development of the mu opioid receptor antagonists by Yuan, Yunyun, Elbegdorj, Orgil, Chen, Jianyang, Akubathini, Shashidhar K, Beletskaya, Irina O, Selley, Dana E, Zhang, Yan

“…Mu opioid receptor antagonists have been applied to target a variety of diseases clinically. The current study is designed to explore the structure selectivity…”
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The effects of delta9-tetrahydrocannabinol physical dependence on brain cannabinoid receptors by Breivogel, Christopher S, Scates, Susan M, Beletskaya, Irina O, Lowery, Olivia B, Aceto, Mario D, Martin, Billy R

“…The effects of chronic Delta(9)-tetrahydrocannabinol on cannabinoid receptor levels and receptor-G-protein coupling were investigated. Male Sprague-Dawley rats…”
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The effects of Δ9-tetrahydrocannabinol physical dependence on brain cannabinoid receptors by BREIVOGEL, Christopher S, SCATES, Susan M, BELETSKAYA, Irina O, LOWERY, Olivia B, ACETO, Mario D, MARTIN, Billy R

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The effects of Δ 9-tetrahydrocannabinol physical dependence on brain cannabinoid receptors by Breivogel, Christopher S, Scates, Susan M, Beletskaya, Irina O, Lowery, Olivia B, Aceto, Mario D, Martin, Billy R

“…The effects of chronic Δ 9-tetrahydrocannabinol on cannabinoid receptor levels and receptor–G-protein coupling were investigated. Male Sprague–Dawley rats were…”
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