Search Results - "Belelli, D"

Neurosteroids: endogenous regulators of the GABA A receptor by Lambert, Jeremy J, Belelli, Delia

“…GABA(A) (gamma-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically…”
Get full text

GABAA receptor subtype involvement in addictive behaviour by Stephens, D. N., King, S. L., Lambert, J. J., Belelli, D., Duka, T.

“…GABAA receptors form the major class of inhibitory neurotransmitter receptors in the mammalian brain. This review sets out to summarize the evidence that…”
Get full text

GABA A receptor subtype involvement in addictive behaviour by Stephens, D N, King, S L, Lambert, J J, Belelli, D, Duka, T

“…GABA receptors form the major class of inhibitory neurotransmitter receptors in the mammalian brain. This review sets out to summarize the evidence that…”
Get full text

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABAA receptors by Jensen, ML, Wafford, KA, Brown, AR, Belelli, D, Lambert, JJ, Mirza, NR

“…Background and Purpose Most GABAA receptor subtypes comprise 2α, 2β and 1γ subunit, although for some isoforms, a δ replaces a γ‐subunit. Extrasynaptic δ‐GABAA…”
Get full text

Endogenous neurosteroids influence synaptic GABAA receptors during postnatal development by Belelli, D., Brown, A. R., Mitchell, S. J., Gunn, B. G., Herd, M. B., Phillips, G. D., Seifi, M., Swinny, J. D., Lambert, J. J.

“…GABA plays a key role in both embryonic and neonatal brain development. For example, during early neonatal nervous system maturation, synaptic transmission,…”
Get full text

Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule by Zhang, H, Etherington, L-A, Hafner, A-S, Belelli, D, Coussen, F, Delagrange, P, Chaouloff, F, Spedding, M, Lambert, J J, Choquet, D, Groc, L

“…The plasticity of excitatory synapses is an essential brain process involved in cognitive functions, and dysfunctions of such adaptations have been linked to…”
Get full text

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors by Jensen, M L, Wafford, K A, Brown, A R, Belelli, D, Lambert, J J, Mirza, N R

“…Most GABA(A) receptor subtypes comprise 2α, 2β and 1γ subunit, although for some isoforms, a δ replaces a γ-subunit. Extrasynaptic δ-GABA(A) receptors are…”
Get full text

Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus by Wafford, K A, van Niel, M B, Ma, Q P, Horridge, E, Herd, M B, Peden, D R, Belelli, D, Lambert, J J

“…Inhibition in the brain is dominated by the neurotransmitter gamma-aminobutyric acid (GABA); operating through GABA(A) receptors. This form of neural…”
Get full text

Neuroactive steroids and inhibitory neurotransmission: Mechanisms of action and physiological relevance by Belelli, D., Herd, M.B., Mitchell, E.A., Peden, D.R., Vardy, A.W., Gentet, L., Lambert, J.J.

“…Dysfunction of GABA A receptor-mediated inhibition is implicated in a number of neurological and psychiatric conditions including epilepsy and affective…”
Get full text

Novel compounds selectively enhance δ subunit containing GABAA receptors and increase tonic currents in thalamus by Wafford, K.A., van Niel, M.B., Ma, Q.P., Horridge, E., Herd, M.B., Peden, D.R., Belelli, D., Lambert, J.J.

“…Inhibition in the brain is dominated by the neurotransmitter γ-aminobutyric acid (GABA); operating through GABAA receptors. This form of neural inhibition was…”
Get full text

Endogenous neurosteroids influence synaptic GABA A receptors during postnatal development by Belelli, D, Brown, A R, Mitchell, S J, Gunn, B G, Herd, M B, Phillips, G D, Seifi, M, Swinny, J D, Lambert, J J

“…GABA plays a key role in both embryonic and neonatal brain development. For example, during early neonatal nervous system maturation, synaptic transmission,…”
Get full text

The influence of subunit composition on the interaction of neurosteroids with GABA A receptors by Belelli, Delia, Casula, Anna, Ling, Alice, Lambert, Jeremy J.

“…The influence of the subunit composition of human GABA A receptors upon the GABA-modulatory properties of 5α-pregnan-3α-ol-20-one (5α,3α) has been examined…”
Get full text

The contraceptive agent Provera enhances GABA(A) receptor-mediated inhibitory neurotransmission in the rat hippocampus: evidence for endogenous neurosteroids? by Belelli, Delia, Herd, Murray B

“…Neurosteroids typified by 5alpha-pregnan-3alpha-ol-20-one (5alpha3alpha) have emerged as the most potent endogenous positive modulators of the GABAA receptor,…”
Get full text

S.12.02 Histaminergic regulation of presumed serotonin neurons in the dorsal raphe nucleus by Panetta, K, Lambert, J.J, Belelli, D

Get full text

P.1.017 Histaminergic regulation of presumed serotonin neurons in the dorsal raphe nucleus by Panetta, K, Belelli, D, Lambert, J

Get full text

Neurosteroids and GABA A receptor function by Lambert, Jeremy J., Belelli, Delia, Hill-Venning, Claire, Peters, John A.

“…In 1984, a potent and selective interaction of the steroidal anaesthetic alphaxalone with the GABA A receptor was demonstrated. Subsequent studies established…”
Get full text

S.07.05 The effects of early life stress on nucleus accumbens GABAA receptor function and cocaine mediated behaviour by Mitchell, S.J, Maguire, E.P, Gunn, B.G, Cunningham, L, Herd, M.B, Swinny, J.D, Lambert, J.J, Belelli, D

Get full text

P.2.015 The effects of early life stress on nucleus accumbens GABAA receptor function and cocaine mediated behaviour by Mitchell, S, Maguire, E.P, Gunn, B.G, Cunningham, L, Herd, M.B, Swinny, J.D, Lambert, J.J, Belelli, D

Get full text

The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors by Weir, C.J., Ling, A.T.Y., Belelli, D, Wildsmith, J.A.W., Peters, J.A., Lambert, J.J.

“…Anaesthetic steroids are established positive allosteric modulators of GABAA receptors, but little is known concerning steroid modulation of…”
Get full text

S.24.01 Neurosteroids: endogenous modulators of GABA-A receptor by Lambert, J, Gunn, B, Brown, A, Mitchell, E, Simmons, R, Herd, M.B, Belelli, D

Get full text