Search Results - "Belani, Jitendra D"

Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response by Myers, Benjamin R., Sever, Navdar, Chong, Yong Chun, Kim, James, Belani, Jitendra D., Rychnovsky, Scott, Bazan, J. Fernando, Beachy, Philip A.

“…Hedgehog (Hh) signaling during development and in postembryonic tissues requires activation of the 7TM oncoprotein Smoothened (Smo) by mechanisms that may…”
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Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions by Bukiya, Anna N, Belani, Jitendra D, Rychnovsky, Scott, Dopico, Alex M

“…The activity (Po) of large-conductance voltage/Ca(2+)-gated K(+) (BK) channels is blunted by cholesterol levels within the range found in natural membranes. We…”
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Aryne Multicomponent Reactions by Directed C−H Activation by Sunnam, Sunil Kumar, Belani, Jitendra D.

“…Arylation via ortho C−H activation by the aid of directing groups has been explored recently by many researchers. Herein, a palladium‐catalyzed C−H arylation…”
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Dual Roles for Cholesterol in Mammalian Cells by Fang Xu, Rychnovsky, Scott D., Jitendra D. Belani, Hobbs, Helen H., Cohen, Jonathan C., Rawson, Robert B.

“…The structural features of sterols required to support mammalian cell growth have not been fully defined. Here, we use mutant CHO cells that synthesize only…”
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Chirality Effect on Cholesterol Modulation of Protein Function by Belani, Jitendra D

“…Cholesterol is a key steroidal, lipid biomolecule found abundantly in plasma membranes of eukaryotic cells. It is an important structural component of cellular…”
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Role of chirality in peptide-induced formation of cholesterol-rich domains by Epand, Richard M, Rychnovsky, Scott D, Belani, Jitendra D, Epand, Raquel F

“…The chiral specificity of the interactions of peptides that induce the formation of cholesterol-rich domains has not been extensively investigated. Both the…”
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Substrate Chirality and Specificity of Diacylglycerol Kinases and the Multisubstrate Lipid Kinase by Epand, Richard M, Shulga, Yulia V, Timmons, Heath C, Perri, Alexandra L, Belani, Jitendra D, Perinpanathan, Kirishanth, Johnson-McIntire, Laura Beth, Bajjalieh, Sandra, Dicu, Armela O, Elias, Cynthia, Rychnovsky, Scott D, Topham, Matthew K

“…The α, ζ, and ε isoforms of diacylglycerol kinase exhibit a high degree of stereospecificity in the phosphorylation of diacylglycerol. In comparison, a…”
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Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses by Kristiana, Ika, Luu, Winnie, Stevenson, Julian, Cartland, Sian, Jessup, Wendy, Belani, Jitendra D, Rychnovsky, Scott D, Brown, Andrew J

“…How cholesterol is sensed to maintain homeostasis has been explained by direct binding to a specific protein, Scap, or through altering the physical properties…”
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Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitution by Wang, Jin, Sun, Fang, Zhang, Da-wei, Ma, Yongming, Xu, Fang, Belani, Jitendra D, Cohen, Jonathan C, Hobbs, Helen H, Xie, Xiao-Song

“…ATP-binding cassette transporters G5 and G8 are half-transporters expressed on the apical membranes of enterocytes and hepatocytes that limit intestinal uptake…”
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A Concise Synthesis of ent-Cholesterol by Belani, Jitendra D, Rychnovsky, Scott D

“…ent-Cholesterol was synthesized in 16 steps from commercially available (S)-citronellol. The overall yield for the synthesis was 2.0%. This route is amenable…”
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Design, synthesis and biological evaluation of a series of thioamides as non-nucleoside reverse transcriptase inhibitors by Mehanna, Ahmed S, Belani, Jitendra D, Kelley, Charles J, Pallansc, Luke A

“…A series of thioamides were designed as bio-isosteres to the non-nucleoside reverse transcriptase inhibitor trovirdine by replacement of the thiourea NH groups…”
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Sterol Transfer by ABCG5 and ABCG8 by Wang, Jin, Sun, Fang, Zhang, Da-wei, Ma, Yongming, Xu, Fang, Belani, Jitendra D., Cohen, Jonathan C., Hobbs, Helen H., Xie, Xiao-Song

“…ATP-binding cassette transporters G5 and G8 are half-transporters expressed on the apical membranes of enterocytes and hepatocytes that limit intestinal uptake…”
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Cholesterol through the Looking Glass by Kristiana, Ika, Luu, Winnie, Stevenson, Julian, Cartland, Sian, Jessup, Wendy, Belani, Jitendra D., Rychnovsky, Scott D., Brown, Andrew J.

“…How cholesterol is sensed to maintain homeostasis has been explained by direct binding to a specific protein, Scap, or through altering the physical properties…”
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Specificity of cholesterol and analogs to modulate BK channels points to direct sterol–channel protein interactions by Bukiya, Anna N., Belani, Jitendra D., Rychnovsky, Scott, Dopico, Alex M.

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Strict Structural Requirements for Cholesterol to Inhibit BK Channels Point to Specific Steroid-Protein Interactions by Bukiya, Anna N., Singh, Aditya K., Belani, Jitendra D., Rychnovsky, Scott, Dopico, Alejandro M.

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Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions by Bukiya, Anna N, Belani, Jitendra D, Rychnovsky, Scott, Dopico, Alex M

“…The activity (Po) of large-conductance voltage/Ca2+-gated K+ (BK) channels is blunted by cholesterol levels within the range found in natural membranes. We…”
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Multidrug resistance protein 1 is not associated to detergent-resistant membranes by Cerf, Emilie, Gasper, Régis, Rychnovsky, Scott, Chang, Xiu-bao, Buyse, Frédéric, Ruysschaert, Jean-Marie

“…Multidrug resistance protein 1 (MRP1) is a member of the ATP-binding cassette superfamily. Using the energy provided by ATP hydrolysis, it transports a broad…”
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Corrigendum to “Multidrug resistance protein 1 is not associated to detergent-resistant membranes” [Biochem. Biophys. Res. Commun. 355 (2007) 1025–1030] by Cerf, Emilie, Gasper, Régis, Belani, Jitendra D., Rychnovsky, Scott, Chang, Xiu-bao, Buyse, Frédéric, Ruysschaert, Jean-Marie

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Total syntheses of ent-cholesterol by Belani, Jitendra D

“…This dissertation presents total syntheses of ent-cholesterol. The original synthesis reported by Rychnovsky was optimized and the molecule was prepared in 23…”
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Total syntheses of ent-cholesterol by Belani, Jitendra D

“…This dissertation presents total syntheses of ent-cholesterol. The original synthesis reported by Rychnovsky was optimized and the molecule was prepared in 23…”
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