Search Results - "Belanger, Adam J."

Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors by Yamakawa, Midori, Liu, Louis X, Date, Taro, Belanger, Adam J, Vincent, Karen A, Akita, Geoffrey Y, Kuriyama, Takayuki, Cheng, Seng H, Gregory, Richard J, Jiang, Canwen

“…ABSTRACT—Hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of vascular endothelial growth factor (VEGF) and other hypoxia-responsive…”
Get full text

Inhibition of osteoclastogenesis by prolyl hydroxylase inhibitor dimethyloxallyl glycine by Leger, Andrew J, Altobelli, Allison, Mosquea, Leocadia M, Belanger, Adam J, Song, Antonius, Cheng, Seng H, Jiang, Canwen, Yew, Nelson S

“…Studies examining the effects of hypoxia upon osteoclast biology have consistently revealed a stimulatory effect; both osteoclast differentiation and…”
Get full text

Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia-Inducible Factor 1 by Liu, Louis X., Lu, Hsienwie, Luo, Yuxia, Date, Taro, Belanger, Adam J., Vincent, Karen A., Akita, Geoffrey Y., Goldberg, Mark, Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…Hypoxia regulates expression of vascular endothelial growth factor (VEGF) by increasing its transcription and by stabilizing its mRNA. Despite the pivotal role…”
Get full text

Comparison of Microflow and Analytical Flow Liquid Chromatography Coupled to Mass Spectrometry Global Metabolomics Methods Using a Urea Cycle Disorder Mouse Model by Geller, Sarah, Lieberman, Harvey, Belanger, Adam J, Yew, Nelson S, Kloss, Alla, Ivanov, Alexander R

“…Microscale-based separations are increasingly being applied in the field of metabolomics for the analysis of small-molecule metabolites. These methods have the…”
Get full text

Excretion of excess nitrogen and increased survival by loss of SLC6A19 in a mouse model of ornithine transcarbamylase deficiency by Belanger, Adam J., Gefteas, Estelle, Przybylska, Malgorzata, Geller, Sarah, Anarat‐Cappillino, Gülbenk, Kloss, Alla, Yew, Nelson S.

“…Protein catabolism ultimately yields toxic ammonia, which must be converted to urea by the liver for renal excretion. In extrahepatic tissues, ammonia is…”
Get full text

Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor α/retinoid X receptor by Belanger, Adam J., Luo, Zhengyu, Vincent, Karen A., Akita, Geoffrey Y., Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…In response to cellular hypoxia, cardiomyocytes adapt to consume less oxygen by shifting ATP production from mitochondrial fatty acid β-oxidation to…”
Get full text

Myocardial expression of baculoviral p35 alleviates doxorubicin-induced cardiomyopathy in rats by Date, Taro, Luo, Zhengyu, Yamakawa, Midori, Belanger, Adam J, Scaria, Abraham, Cheng, Seng H, Gregory, Richard J, Mochizuki, Seibu, Jiang, Canwen

“…The clinical use of doxorubicin, one of the most effective antitumor drugs, is limited by its cardiotoxicity, which results in irreversible cardiomyopathy and…”
Get more information

A hypoxic inducible factor-1α hybrid enhances collateral development and reduces vascular leakage in diabetic rats by Kajiwara, Hidetoshi, Luo, Zhengyu, Belanger, Adam J., Urabe, Akihiro, Vincent, Karen A., Akita, Geoffrey Y., Cheng, Seng H., Mochizuki, Seibu, Gregory, Richard J., Jiang, Canwen

“…Background Diabetes mellitus is a common comorbidity of atherosclerosis. Hypoxia‐inducible factor‐1 (HIF‐1) is the master regulator of the angiogenic response…”
Get full text

Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis by Yamakawa, Midori, Liu, Louis X, Belanger, Adam J, Date, Taro, Kuriyama, Takayuki, Goldberg, Mark A, Cheng, Seng H, Gregory, Richard J, Jiang, Canwen

“…The hereditary von Hippel-Lindau (VHL) syndrome predisposes sufferers to highly vascularized tumors such as renal clear cell carcinoma (RCC) and central…”
Get more information

Differential effects of membrane and soluble Fas ligand on cardiomyocytes: role in ischemia/reperfusion injury by Date, Taro, Mochizuki, Seibu, Belanger, Adam J., Yamakawa, Midori, Luo, Zhengyu, Vincent, Karen A., Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…Cardiomyocyte apoptosis by Fas ligand (FasL)/Fas signaling is associated with various pathophysiological conditions, such as ischemia/reperfusion injury and…”
Get full text

Gene expression profiles in human cardiac cells subjected to hypoxia or expressing a hybrid form of HIF-1 alpha by Jiang, Canwen, Lu, Hsienwie, Vincent, Karen A, Shankara, Srinivas, Belanger, Adam J, Cheng, Seng H, Akita, Geoffrey Y, Kelly, Ralph A, Goldberg, Mark A, Gregory, Richard J

“…The cellular response to hypoxia depends on rapid posttranslational modifications of proteins as well as regulation of gene expression. We performed serial…”
Get full text

Adenovirus-mediated expression of p35 prevents hypoxia/reoxygenation injury by reducing reactive oxygen species and caspase activity by DATE, Taro, BELANGER, Adam J, MOCHIZUKI, Seibu, SULLIVAN, Jennifer A, LIU, Louis X, SCARIA, Abraham, CHENG, Seng H, GREGORY, Richard J, JIANG, Canwen

“…This study aimed to examine the effects of adenovirus-mediated expression of p35, a baculovirus gene, on apoptosis induced by hypoxia/reoxygenation (H/R) in…”
Get full text

Fas ligand/Fas-mediated apoptosis in human coronary artery smooth muscle cells : therapeutic implications of fratricidal mode of action by BELANGER, Adam J, SCARIA, Abraham, HSIENWIE LU, SULLIVAN, Jennifer A, CHENG, Seng H, GREGORY, Richard J, CANWEN JIANG

“…This study aimed to determine the mode of action of Fas ligand (FasL)/Fas at mediating apoptosis so as to evaluate the potential of FasL in gene therapy for…”
Get full text

Enhancement of Fas ligand-induced inhibition of neointimal formation in rabbit femoral and iliac arteries by coexpression of p35 by Luo, Z, Garron, T, Palasis, M, Lu, H, Belanger, A J, Scaria, A, Vincent, K A, Date, T, Akita, G Y, Cheng, S H, Barry, J, Gregory, R J, Jiang, C

“…Adenovirus-mediated gene transfer of Fas ligand (FasL) inhibits neointimal formation in balloon-injured rat carotid arteries. Vascular smooth muscle (VSM)…”
Get more information

Hypoxia Up-regulates Expression of Peroxisome Proliferator-activated Receptor γ Angiopoietin-related Gene (PGAR) in Cardiomyocytes: Role of Hypoxia Inducible Factor 1α by Belanger, Adam J., Lu, Hsienwie, Date, Taro, Liu, Louis X., Vincent, Karen A., Akita, Geoffery Y., Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…A. J. Belanger, H. Lu, T. Date, L. X. Liu, K. A. Vincent, G. Y. Akita, S. H. Cheng, R. J. Gregory and C. Jiang. Hypoxia Up-regulates Expression of Peroxisome…”
Get full text

Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor {alpha}/retinoid X receptor by Belanger, Adam J., Luo Zhengyu, Vincent, Karen A., Akita, Geoffrey Y., Cheng, Seng H., Gregory, Richard J., Jiang Canwen

“…In response to cellular hypoxia, cardiomyocytes adapt to consume less oxygen by shifting ATP production from mitochondrial fatty acid {beta}-oxidation to…”
Get full text

A hypoxic inducible factor-1[alpha] hybrid enhances collateral development and reduces vascular leakage in diabetic rats by Kajiwara, Hidetoshi, Luo, Zhengyu, Belanger, Adam J, Urabe, Akihiro, Vincent, Karen A, Akita, Geoffrey Y, Cheng, Seng H, Mochizuki, Seibu, Gregory, Richard J, Jiang, Canwen

“…Background Diabetes mellitus is a common comorbidity of atherosclerosis. Hypoxia-inducible factor-1 (HIF-1) is the master regulator of the angiogenic response…”
Get full text

A hypoxic inducible factor-1a hybrid enhances collateral development and reduces vascular leakage in diabetic rats by Kajiwara, Hidetoshi, Luo, Zhengyu, Belanger, Adam J, Urabe, Akihiro, Vincent, Karen A, Akita, Geoffrey Y, Cheng, Seng H, Mochizuki, Seibu, Gregory, Richard J, Jiang, Canwen

“…Background Diabetes mellitus is a common comorbidity of atherosclerosis. Hypoxia-inducible factor-1 (HIF-1) is the master regulator of the angiogenic response…”
Get full text

A constitutively active hypoxia-inducible factor-1alpha/VP16 hybrid factor activates expression of the human B-type natriuretic peptide gene by Luo, Yuxia, Jiang, Canwen, Belanger, Adam J, Akita, Geoffrey Y, Wadsworth, Samuel C, Gregory, Richard J, Vincent, Karen A

“…Hypoxia-inducible factor-1 (HIF-1) is a primary regulator of the physiological response to hypoxia. A recombinant adenovirus expressing a constitutively active…”
Get more information

Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury by Date, Taro, Mochizuki, Seibu, Belanger, Adam J, Yamakawa, Midori, Luo, Zhengyu, Vincent, Karen A, Cheng, Seng H, Gregory, Richard J, Jiang, Canwen

“…Preconditioning in cultured cardiomyocytes elevates the expression of several protective genes including Glut-4 and heat shock protein (HSP)70…”
Get more information