Search Results - "Belal, Amany"

3D-Pharmacophore Modeling, Molecular Docking, and Virtual Screening for Discovery of Novel CDK4/6 Selective Inhibitors by Belal, Amany

“…Structure-based pharmacophore mapping, drug-likeness and ADMET profiles were used as tools in our virtual screening process, in addition to molecular docking…”
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Pyrrolizines as Potential Anticancer Agents: Design, Synthesis, Caspase-3 activation and Micronucleus (MN) Induction by Belal, Amany

“…For further exploration of the promising pyrrolizine scaffold and in continuation of our previous work, that proved the potential anticancer activity of the…”
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Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors by Belal, Amany, Abdel Gawad, Nagwa M., Mehany, Ahmed B. M., Abourehab, Mohammed A. S., Elkady, Hazem, Al-Karmalawy, Ahmed A., Ismael, Ahmed S.

“…A new series of 1H-pyrrole (6a-c, 8a-c), pyrrolo[3,2-d]pyrimidines (9a-c) and pyrrolo[3,2-e][1, 4]diazepines (11a-c) were designed and synthesised. These…”
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Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3- b ] Pyrrole Derivatives by Kamel, Moumen S, Belal, Amany, Aboelez, Moustafa O, Shokr, E Kh, Abdel-Ghany, H, Mansour, Hany S, Shawky, Ahmed M, El-Remaily, Mahmoud Abd El Aleem Ali Ali

“…Novel pyrrolo [2,3- ] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chemical structures of the…”
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Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies by Abo Elmaaty, Ayman, Eldehna, Wagdy, Khattab, Muhammad, Kutkat, Omnia, Alnajjar, Radwan, El-Taweel, Ahmed, Al-Rashood, Sara, Abourehab, Mohammed, Binjubair, Faizah, Saleh, Mohamed, Belal, Amany, Al-Karmalawy, Ahmed

“…In this article, 34 anticoagulant drugs were screened in silico against the main protease (Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux,…”
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Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management by Belal, Amany, Elanany, Mohamed A, Santali, Eman Y, Al-Karmalawy, Ahmed A, Aboelez, Moustafa O, Amin, Ali H, Abdellattif, Magda H, Mehany, Ahmed B M, Elkady, Hazem

“…Keratoconus (KC) is a serious disease that can affect people of any race or nationality, although the exact etiology and pathogenic mechanism are still…”
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Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents by Tawfik, Haytham O., Belal, Amany, Abourehab, Mohammed A. S., Angeli, Andrea, Bonardi, Alessandro, Supuran, Claudiu T., El-Hamamsy, Mervat H.

“…Herein we reported the design and synthesis of two series comprising twenty-two benzenesulfonamides that integrate the s-triazine moiety. Target compounds…”
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Evaluating the ability of some natural phenolic acids to target the main protease and AAK1 in SARS COV-2 by Ghamry, Heba I., Belal, Amany, El-Ashrey, Mohamed Kandeel, Tawfik, Haytham O., Alsantali, Reem I., Obaidullah, Ahmad J., El-Mansi, Ahmed A., Abdelrahman, Doaa

“…Researchers are constantly searching for drugs to combat the coronavirus pandemic caused by SARS-CoV-2, which has lasted for over two years. Natural compounds…”
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Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico , In Vitro , and SAR Studies by Ma, Chao, Taghour, Mohammed S, Belal, Amany, Mehany, Ahmed B M, Mostafa, Naglaa, Nabeeh, Ahmed, Eissa, Ibrahim H, Al-Karmalawy, Ahmed A

“…Guided by the structural optimization principle and the promising anticancer effect of the quinoxaline nucleus, a new series of novel HDAC inhibitors were…”
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Design, synthesis, and molecular docking studies of novel pomalidomide-based PROTACs as potential anti-cancer agents targeting EGFRWT and EGFRT790M by O. Aboelez, Moustafa, Belal, Amany, Xiang, Guangya, Ma, Xiang

“…A new class of EGFR PROTACs based on pomalidomide was developed, synthesised, and tested for their cytotoxic activity against a panel of human cancer cells…”
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An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance by Alrobaian, Majed, Azwari, Sana Al, Belal, Amany, Eldeab, Hany A

“…Two series of novel 5-arylazo-3-cyano-2-(2″,3″,4″,6″-tetra- -acetyl-β-d-galacto pyranosyloxy) pyridines and 3-cyano-2-(2″,3″,4″,6″-tetra-…”
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Optimization of tamoxifen solubility in carbon dioxide supercritical fluid and investigating other molecular targets using advanced artificial intelligence models by Alshahrani, Saad M., Alshetaili, Abdullah S., Alfadhel, Munerah M., Belal, Amany, Abourehab, Mohammad A. S., Al Saqr, Ahmed, Almutairy, Bjad K., Venkatesan, Kumar, Alsubaiyel, Amal M., Pishnamazi, Mahboubeh

“…Particle size, shape and morphology can be considered as the most significant functional parameters, their effects on increasing the performance of oral solid…”
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Discovery of Some Heterocyclic Molecules as Bone Morphogenetic Protein 2 (BMP-2)-Inducible Kinase Inhibitors: Virtual Screening, ADME Properties, and Molecular Docking Simulations by Belal, Amany, Elkady, Hazem, Al-Karmalawy, Ahmed A, Amin, Ali H, Ghoneim, Mohammed M, El-Sherbiny, Mohamed, Al-Serwi, Rasha Hamed, Abdou, Mohamed Attia, Ibrahim, Mona H, Mehany, Ahmed B. M

“…Bone morphogenetic proteins (BMPs) are growth factors that have a vital role in the production of bone, cartilage, ligaments, and tendons. Tumors’ upregulation…”
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Author Correction: Optimization of tamoxifen solubility in carbon dioxide supercritical fluid and investigating other molecular targets using advanced artificial intelligence models by Alshahrani, Saad M., Alshetaili, Abdullah S., Alfadhel, Munerah M., Belal, Amany, Abourehab, Mohammad A. S., Al Saqr, Ahmed, Almutairy, Bjad K., Venkatesan, Kumar, Alsubaiyel, Amal M., Pishnamazi, Mahboubeh

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Computational simulation and target prediction studies of solubility optimization of decitabine through supercritical solvent by Alshahrani, Saad M., Almutairy, Bjad K., Alfadhel, Munerah M., Belal, Amany, Abourehab, Mohammed A. S., Saqr, Ahmed Al, Alshetaili, Abdullah S., Venkatesan, Kumar, Alsubaiyel, Amal M., Pishnamazi, Mahboubeh

“…Computational analysis of drug solubility was carried out using machine learning approach. The solubility of Decitabine as model drug in supercritical CO 2 was…”
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Tolmetin Sodium Fast Dissolving Tablets for Rheumatoid Arthritis Treatment: Preparation and Optimization Using Box-Behnken Design and Response Surface Methodology by Elsayed, Mahmoud M A, Aboelez, Moustafa O, Elsadek, Bakheet E M, Sarhan, Hatem A, Khaled, Khaled Ali, Belal, Amany, Khames, Ahmed, Hassan, Yasser A, Abdel-Rheem, Amany A, Elkaeed, Eslam B, Raafat, Mohamed, Elsadek, Mahmoud Elkot Mostafa

“…Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM is used to treat inflammation, skeletal muscle injuries, and discomfort…”
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Novel saccharin analogs as promising antibacterial and anticancer agents: synthesis, DFT, POM analysis, molecular docking, molecular dynamic simulations, and cell-based assay by Abdellattif, Magda H., Elkamhawy, Ahmed, Hagar, Mohamed, Hadda, Taibi Ben, Shehab, Wesam S., Mansy, Wael, Belal, Amany, Arief, M. M. H., Hussien, Mostafa A.

“…Saccharine is a pharmacologically significant active scaffold for various biological activities, including antibacterial and anticancer activities. Herein,…”
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Hybridized Quinoline Derivatives as Anticancer Agents: Design, Synthesis, Biological Evaluation and Molecular Docking by Selim, Mohamed R, Zahran, Medhat A, Belal, Amany, Abusaif, Moustafa S, Shedid, Said A, Mehany, Ahmed B M, Elhagali, Gameel A M, Ammar, Yousry A

“…Conjugating quinolones with different bioactive pharmacophores to obtain potent anticancer active agents. Fused pyrazolopyrimidoquinolines 3a-d, Schiff bases…”
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Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies by Saad, Mohamed H., El-Moselhy, Tarek F., S, El-Din, Nabaweya, Mehany, Ahmed B. M., Belal, Amany, Abourehab, Mohammed A. S., Tawfik, Haytham O., El-Hamamsy, Mervat H.

“…Two new series of symmetric (1a-h) and asymmetric (2a-l) 1,4-DHP derivatives were designed, synthesised, and evaluated as anticancer agents. In vitro…”
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Correction: Belal et al. Therapeutic Potential of Zeolites/Vitamin B12 Nanocomposite on Complete Freund's Adjuvant-Induced Arthritis as a Bone Disorder: In Vivo Study and Bio-Molecular Investigations. Pharmaceuticals 2023, 16 , 285 by Belal, Amany, Mahmoud, Rehab, Taha, Mohamed, Halfaya, Fatma Mohamed, Hassaballa, Ahmed, Elbanna, Esraa Salah, Khaled, Esraa, Farghali, Ahmed, Abo El-Ela, Fatma I, Mahgoub, Samar M, Ghoneim, Mohammed M, Zaky, Mohamed Y

“…In the original publication [...]…”
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