Implementing the WHO Global Initiative for Childhood Cancer in Morocco: Survival study for the six indexed childhood cancers

Background In 2018, the World Health Organization (WHO) launched the Global Initiative for Childhood Cancer (GICC). The goal is to achieve a global survival rate of at least 60% for all children with cancer by 2030. Morocco was designated as a pilot country for this initiative. Procedure This retros...

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Published in:	Pediatric blood & cancer Vol. 69; no. 10; pp. e29788 - n/a
Main Authors:	Mechita, Nada Bennani, Cherkaoui, Siham, Abousselham, Loubna, Benmiloud, Sarra, Kili, Amina, Kababri, Maria El, Maani, Khadija, Houdzi, Jamila El, Benajiba, Noufissa, Madani, Abdellah, Bennani, Maria, Belakhel, Latefa, Bouffet, Eric, Patte, Catherine, Harif, Mhamed, Youbi, Mohammed, Hessissen, Laila
Format:	Journal Article
Language:	English
Published:	Glenview Wiley Subscription Services, Inc 01-10-2022
Subjects:	Acute lymphoblastic leukemia Brain tumors Burkitt's lymphoma Cancer childhood cancer Children Glioma Hematology Hodgkin's lymphoma Lymphoma Medical prognosis Oncology Patients Pediatrics Retina Retinoblastoma Survival WHO initiative Morocco
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Summary:	Background In 2018, the World Health Organization (WHO) launched the Global Initiative for Childhood Cancer (GICC). The goal is to achieve a global survival rate of at least 60% for all children with cancer by 2030. Morocco was designated as a pilot country for this initiative. Procedure This retrospective study included a cohort of children aged 0–15 years, with one of the six indexed cancers (acute lymphoblastic leukemia [ALL], Burkitt lymphoma [BL], Hodgkin lymphoma, retinoblastoma [RB], Wilms tumor or nephroblastoma, low‐grade glioma), diagnosed between January 1, 2017 and December 31, 2019 at the six Moroccan Pediatric Hematology and Oncology units. Patients were followed‐up until August 31, 2020. The Kaplan–Meier method was used to estimate survival rates, the log‐rank test for comparing survival curves, and the Cox model for identifying prognostic factors. Results Data on 878 patients were included in the study. The most frequently reported cancer type was ALL (n = 383, 43.6%), followed by Wilms tumor (n = 139, 15.8%) and BL (n = 133, 15%). Most patients were less than 5 years of age (n = 446, 50.9%) and the male/female ratio was 1.46. The 1, 2, and 3‐year overall survival rates were 80.1%, 73.6%, and 68.2%, respectively. In a multivariable Cox regression model, care center, cancer type, age group, and distance to the care center were statistically significantly associated to survival. Patients aged 10 years and older and patients living more than 100 km from the care center were more likely to die (respectively, HR = 1.39, p = .045 and HR = 1.44, p = .010). Conclusion The reported results represent the baseline for measuring the impact of GICC implementation in Morocco.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1545-5009 1545-5017
DOI:	10.1002/pbc.29788