Selective determination of an ovarian cancer biomarker at low concentrations with surface imprinted nanotube based chemosensor

Selective determination of an ovarian cancer biomarker at low concentrations with surface imprinted nanotube based chemosensor

•Surface imprinted PPy-NT based chemosensor was devised for CA125 biomarker determination.•CA125 imprinted PPy nanotubes were synthesized via vapor deposition polymerization.•The chemosensor sensitivity and selectivity towards the CA125 biomarker were favorable. In this study, an electrochemical che...

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Bibliographic Details
Published in:Bioelectrochemistry (Amsterdam, Netherlands) Vol. 157; p. 108655
Main Authors: Can, Faruk, Akkas, Tugce, Bekler, Sevinc Yagmur, Takmakli, Selma, Uzun, Lokman, Ozaydin Ince, Gozde
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-06-2024
Subjects:
Biomarkers, Tumor
CA125
Electrochemical biosensor
Electrochemical Techniques - methods
Electrodes
Humans
Limit of Detection
Molecular Imprinting - methods
Molecularly imprinted polymer
Nanotubes
Neoplasms
Ovarian cancer
Polymers - chemistry
Polypyrrole nanotube
Pyrroles - chemistry
Screen-printed electrode
Vapor deposition polymerization
Molecularly imprinted polymer
CA125
Screen-printed electrode
Electrochemical biosensor
Vapor deposition polymerization
Ovarian cancer
Polypyrrole nanotube
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Summary:•Surface imprinted PPy-NT based chemosensor was devised for CA125 biomarker determination.•CA125 imprinted PPy nanotubes were synthesized via vapor deposition polymerization.•The chemosensor sensitivity and selectivity towards the CA125 biomarker were favorable. In this study, an electrochemical chemosensor that utilizes a conductive polymer-based molecularly imprinted polymer (MIP) surface for rapid and reliable determination of CA125 was devised. A novel method has been applied to fabricate CA125 imprinted polypyrrole nanotubes (MI-PPy NT) via vapor deposition polymerization (VDP) as a recognition element for highly selective and sensitive determination of CA125. The chemosensor was prepared by immobilizing MI-PPy NT onto screen-printed gold electrodes (Au-SPE) and the performance of the sensor was evaluated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) in terms of selectivity, sensitivity, linear dynamic concentration range (LDR) and limit of detection (LOD). The MI-PPy NT@Au-SPE sensor exhibited high sensitivity (68.57 μA per decade) to the CA125 concentration ranging from 0.1 U mL−1 to 100 U mL−1 at an LOD of 0.4 U mL−1 with a correlation coefficient of 0.9922. The developed chemosensors with their novel design combined with a facile fabrication method, prove to be promising as future state-of-the-art biosensors.
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ISSN:1567-5394
1878-562X
DOI:10.1016/j.bioelechem.2024.108655