Search Results - "Bekisz, Joseph"

New function of type I IFN: induction of autophagy by Schmeisser, Hana, Bekisz, Joseph, Zoon, Kathryn C

“…Autophagy is a highly conserved cellular process responsible for recycling of intracellular material. It is induced by different stress signals, including…”
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Antiproliferative Properties of Type I and Type II Interferon by Bekisz, Joseph, Baron, Samuel, Balinsky, Corey, Morrow, Angel, Zoon, Kathryn C

“…The clinical possibilities of interferon (IFN) became apparent with early studies demonstrating that it was capable of inhibiting tumor cells in culture and in…”
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Attenuating mutations in the P/C gene of human parainfluenza virus type 1 (HPIV1) vaccine candidates abrogate the inhibition of both induction and signaling of type I interferon (IFN) by wild-type HPIV1 by Van Cleve, William, Amaro-Carambot, Emerito, Surman, Sonja R., Bekisz, Joseph, Collins, Peter L., Zoon, Kathryn C., Murphy, Brian R., Skiadopoulos, Mario H., Bartlett, Emmalene J.

“…Recombinant human parainfluenza virus type 1 (HPIV1) and mutants containing point and deletion (Δ) mutations in the P/C gene (r-C Δ10–15HN T553A, r-C R84G, r-C…”
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Divergence of Binding, Signaling, and Biological Responses to Recombinant Human Hybrid IFN by Hu, Renqiu, Bekisz, Joseph, Hayes, Mark, Audet, Susette, Beeler, Judy, Petricoin, Emanuel, Zoon, Kathryn

“…Three human IFN-alpha hybrids, HY-1 [IFN-alpha21a(1-75)/alpha2c(76-165)], HY-2 [IFN-alpha21a(1-95)/alpha2c(96-165)], and HY-3…”
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Type I interferons induce autophagy in certain human cancer cell lines by Schmeisser, Hana, Fey, Samuel B., Horowitz, Julie, Fischer, Elizabeth R., Balinsky, Corey A., Miyake, Kotaro, Bekisz, Joseph, Snow, Andrew L., Zoon, Kathryn C.

“…Autophagy is an evolutionarily conserved cellular recycling mechanism that occurs at a basal level in all cells. It can be further induced by various stimuli…”
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Immunomodulatory effects of interferons in malignancies by Bekisz, Joseph, Sato, Yuki, Johnson, Chase, Husain, Syed R, Puri, Raj K, Zoon, Kathryn C

“…Investigation of the antitumor and immunomodulatory activities of interferon (IFN) began shortly after the cytokine was discovered in 1957. Early work showed a…”
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Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid‐mediated apoptosis through Bak activation in ovarian cancer cells by Miyake, Kotaro, Bekisz, Joseph, Zhao, Tongmao, Clark, Christopher R., Zoon, Kathryn C.

“…Previously we have shown that interferon (IFN)-α induced apoptosis is predominantly mediated by the upregulation of tumor necrosis factor related…”
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101 by Green, Daniel S., Bekisz, Joseph, Dolan, Michael, Zoon, Kathryn C.

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101 : Characterization of the interferon alpha inducible protein LY6E by Green, Daniel S., Bekisz, Joseph, Dolan, Michael, Zoon, Kathryn C.

“…Ly6E is a member of the Ly family of proteins whose genes are clustered on Chromosome 8. In micro array experiments performed by both our lab and others has…”
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Structural variants of IFNα preferentially promote antiviral functions by Vázquez, Nancy, Schmeisser, Hana, Dolan, Michael A., Bekisz, Joseph, Zoon, Kathryn C., Wahl, Sharon M.

“…IFNα, a cytokine with multiple functions in innate and adaptive immunity and a potent inhibitor of HIV, exerts antiviral activity, in part, by enhancing…”
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18: Characterization of human interferon-alpha subtypes and mutants by Bekisz, Joseph, Eichberg, Daniel, Dolan, Michael, Zhao, Tongmao, Zoon, Kathryn C.

“…IFN-α subtypes and mutants have been cloned in our laboratory in a yeast expression system. The mutants were constructed with point mutations at the C-termini…”
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18 by Bekisz, Joseph, Eichberg, Daniel, Dolan, Michael, Zhao, Tongmao, Zoon, Kathryn C.

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133 by Johnson, Chase L., Green, Daniel S., Bekisz, Joseph, Zoon, Kathryn C.

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133 : In vitro eradication of serous ovarian cancer with IFN-α2α and IFN-γ in combination with monocytes by Johnson, Chase L., Green, Daniel S., Bekisz, Joseph, Zoon, Kathryn C.

“…Interferons (IFNs) have been utilized for their antiproliferative and antitumor effects against human cancers, including hairy cell leukemia, chronic…”
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Induction of autophagy by Type I interferon in human cancer cells (P6217) by Zoon, Kathryn, Fey, Samuel, Horowitz, Julie, Fischer, Elizabeth, Balinsky, Corey, Miyake, Kotaro, Bekisz, Joseph, Snow, Andrew, Schmeisser, Hana

“…Abstract Type I IFNs (interferons) are cytokines that induce an antiviral state in cells and have antiproliferative, pro-apoptotic, and immunomodulatory…”
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PS1-050 Pro-Inflammatory Cytokine Expression in Three Cell Types after Treatment with IFN-alpha subtypes as Assessed by Multiplex Assays by Bekisz, Joseph, Zhao, Tongmao, Zoon, Kathryn C.

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Structural Determinants of IFNα Distinguish Antiviral and Potentially Toxic Functions. (39.7) by Vazquez, Nancy, Schmeisser, Hana, Bekisz, Joseph, Zoon, Kathryn, Wahl, Sharon

“…Abstract Interferon alpha (IFNα), a cytokine with multiple functions in innate and adaptive immunity and a potent inhibitor of human immunodeficiency virus…”
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Human interferons alpha, beta and omega by Bekisz, Joseph, Schmeisser, Hana, Hernandez, Jessica, Goldman, Neil D, Zoon, Kathryn C

“…Type I interferons (IFNs), IFN-alpha, IFN-beta, IFN-omega, IFN-delta and IFN-tau are a family of structurally related, species-specific proteins found only in…”
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Potent antitumor effects of combination therapy with IFNs and monocytes in mouse models of established human ovarian and melanoma tumors by Nakashima, Hideyuki, Miyake, Kotaro, Clark, Christopher R., Bekisz, Joseph, Finbloom, Joel, Husain, Syed R., Baron, Samuel, Puri, Raj K., Zoon, Kathryn C.

“…Interferon-activated monocytes are known to exert cytocidal activity against tumor cells in vitro. Here, we have examined whether a combination of IFN-α2a and…”
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Structural variants of IFNa preferentially promote antiviral functions by VAZQUEZ, Nancy, SCHMEISSER, Hana, DOLAN, Michael A, BEKISZ, Joseph, ZOON, Kathryn C, WAHL, Sharon M

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