Search Results - "Bekay, Rajaa El"
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The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
Published in Metabolites (30-04-2020)“…White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy…”
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Caspase Induction and BCL2 Inhibition in Human Adipose Tissue
Published in Diabetes care (01-03-2013)“…OBJECTIVE Cell death determines the onset of obesity and associated insulin resistance. Here, we analyze the relationship among obesity, adipose tissue…”
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3
Different response to hypoxia of adipose-derived multipotent cells from obese subjects with and without metabolic syndrome
Published in PloS one (22-11-2017)“…Multiple studies suggest that hypoxia, together with inflammation, could be one of the phenomena involved in the onset and progression of obesity-related…”
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4
An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability
Published in Oxidative medicine and cellular longevity (01-01-2016)“…Background. Fragile X syndrome is the most common genetic cause of mental disability. Although many research has been performed, the mechanism underlying the…”
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Myocardial Ischemic Subject's Thymus Fat: A Novel Source of Multipotent Stromal Cells
Published in PloS one (10-12-2015)“…Adipose Tissue Stromal Cells (ASCs) have important clinical applications in the regenerative medicine, cell replacement and gene therapies. Subcutaneous…”
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6
VEGF Gene Expression in Adult Human Thymus Fat: A Correlative Study with Hypoxic Induced Factor and Cyclooxigenase-2
Published in PloS one (14-12-2009)“…It is well known that the adult human thymus degenerates into fat tissue; however, it has never been considered as a potential source of angiogenic factors…”
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Genetic Epidemiology of Glucose-6-Dehydrogenase Deficiency in the Arab World
Published in Scientific reports (17-11-2016)“…A systematic search was implemented using four literature databases (PubMed, Embase, Science Direct and Web of Science) to capture all the causative mutations…”
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The obese healthy paradox: is inflammation the answer?
Published in Biochemical journal (15-08-2010)“…A paradoxical but common finding in the obesity clinic is the identification of individuals who can be considered 'inappropriately' healthy for their degree of…”
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Study of the Potential Association of Adipose Tissue GLP-1 Receptor with Obesity and Insulin Resistance
Published in Endocrinology (Philadelphia) (01-11-2011)“…The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of…”
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10
MiR-221-3p/222-3p Cluster Expression in Human Adipose Tissue Is Related to Obesity and Type 2 Diabetes
Published in International journal of molecular sciences (13-12-2023)“…The progression of obesity and type 2 diabetes (T2D) is intricately linked with adipose tissue (AT) angiogenesis. Despite an established network of microRNAs…”
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Au@16-pH-16/miR-21 mimic nanosystem: An efficient treatment for obesity through browning and thermogenesis induction
Published in Biomedicine & pharmacotherapy (01-02-2024)“…Despite the abundance of registered clinical trials worldwide, the availability of effective drugs for obesity treatment is limited due to their associated…”
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miR-21 mimic blocks obesity in mice: A novel therapeutic option
Published in Molecular therapy. Nucleic acids (03-12-2021)“…MicroRNAs (miRNAs) are promising drug targets for obesity and metabolic disorders. Recently, miRNA mimics are providing a unique mechanism of action that…”
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13
Alpha-tocopherol protects against oxidative stress in the fragile X knockout mouse: an experimental therapeutic approach for the Fmr1 deficiency
Published in Neuropsychopharmacology (New York, N.Y.) (01-03-2009)“…Fragile X syndrome is the most common genetic cause of mental disability. The mechanisms underlying the pathogenesis remain unclear and specific treatments are…”
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Adipogenic impairment of adipose tissue-derived mesenchymal stem cells in subjects with metabolic syndrome: possible protective role of FGF2
Published in The journal of clinical endocrinology and metabolism (01-02-2017)“…Context:The decreased expansion capacity of adipose tissue plays a crucial role in the onset of disorders associated with metabolic syndrome.Objetive:The aim…”
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Proteasome Dysfunction Associated to Oxidative Stress and Proteotoxicity in Adipocytes Compromises Insulin Sensitivity in Human Obesity
Published in Antioxidants & redox signaling (01-09-2015)“…Obesity is characterized by a low-grade systemic inflammatory state and adipose tissue (AT) dysfunction, which predispose individuals to the development of…”
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16
Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects
Published in Scientific reports (30-11-2018)“…Psychiatric disorders have been widely reported to be associated with systemic inflammation upregulation and adiposity. However, there are no data that link…”
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Caspase Induction and BCL2 Inhibition in Human Adipose Tissue: A potential relationship with insulin signaling alteration
Published in Diabetes care (01-03-2013)“…Cell death determines the onset of obesity and associated insulin resistance. Here, we analyze the relationship among obesity, adipose tissue apoptosis, and…”
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Differences in the Osteogenic Differentiation Capacity of Omental Adipose-Derived Stem Cells in Obese Patients With and Without Metabolic Syndrome
Published in Endocrinology (Philadelphia) (01-12-2015)“…Multiple studies have suggested that the reduced differentiation capacity of multipotent adipose tissue-derived mesenchymal stem cells (ASCs) in obese subjects…”
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RPL13A and EEF1A1 Are Suitable Reference Genes for qPCR during Adipocyte Differentiation of Vascular Stromal Cells from Patients with Different BMI and HOMA-IR
Published in PloS one (01-06-2016)“…Real-time or quantitative PCR (qPCR) is a useful technique that requires reliable reference genes for data normalization in gene expression analysis…”
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Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta‐analysis
Published in Diabetes/metabolism research and reviews (01-10-2018)“…Summary The aim of this study was to conduct a systematic review and meta‐analysis and determine the prevalence of diabetic nephropathy (DN) among Arab…”
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