Search Results - "Beitz, Laurie O."

In vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand by Nicolai, Christopher J., Parker, Maura H., Qin, Jim, Tang, Weiliang, Ulrich-Lewis, Justin T., Gottschalk, Rebecca J., Cooper, Sara E., Hernandez Lopez, Susana A., Parrilla, Don, Mangio, Richard S., Ericson, Nolan G., Brandes, Alissa H., Umuhoza, Saluwa, Michels, Kathryn R., McDonnell, Mollie M., Park, Lisa Y., Shin, Seungjin, Leung, Wai-Hang, Scharenberg, Andrew M., Kiem, Hans-Peter, Larson, Ryan P., Beitz, Laurie O., Ryu, Byoung Y.

“…•Lentiviral vectors displaying T-cell activation and costimulatory molecules (VivoVec) generate CAR T cells in vivo without lymphodepletion.•VivoVec…”
Get full text

Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition by Goldbach-Mansky, Raphaela, Dailey, Natalie J, Canna, Scott W, Gelabert, Ana, Jones, Janet, Rubin, Benjamin I, Kim, H. Jeffrey, Brewer, Carmen, Zalewski, Christopher, Wiggs, Edythe, Hill, Suvimol, Turner, Maria L, Karp, Barbara I, Aksentijevich, Ivona, Pucino, Frank, Penzak, Scott R, Haverkamp, Margje H, Stein, Leonard, Adams, Barbara S, Moore, Terry L, Fuhlbrigge, Robert C, Shaham, Bracha, Jarvis, James N, O'Neil, Kathleen, Vehe, Richard K, Beitz, Laurie O, Gardner, Gregory, Hannan, William P, Warren, Robert W, Horn, William, Cole, Joe L, Paul, Scott M, Hawkins, Philip N, Pham, Tuyet Hang, Snyder, Christopher, Wesley, Robert A, Hoffmann, Steven C, Holland, Steven M, Butman, John A, Kastner, Daniel L

“…Among patients with neonatal-onset multisystem inflammatory disease — a disorder characterized by fever, urticarial rash, aseptic meningitis, deforming…”
Get full text

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals by Scharenberg, Andrew M., El-Hillal, Ousama, Fruman, David A., Beitz, Laurie O., Li, Zuomei, Lin, Siqi, Gout, Ivan, Cantley, Lewis C., Rawlings, David J., Kinet, Jean-Pierre

“…Tec family non‐receptor tyrosine kinases have been implicated in signal transduction events initiated by cell surface receptors from a broad range of cell…”
Get full text

SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling by Beitz, Laurie O., Fruman, David A., Kurosaki, Tomohiro, Cantley, Lewis C., Scharenberg, Andrew M.

“…We have recently demonstrated that the D3-phosphoinositide phosphatidylinositol 3,4,5-trisphosphate (PtdIns-3,4,5-P3) is critical for producing sustained…”
Get full text

Activation of Syk Tyrosine Kinase Is Required for c-Cbl-mediated Ubiquitination of FcεRI and Syk in RBL Cells by Paolini, Rossella, Molfetta, Rosa, Beitz, Laurie O., Zhang, Juan, Scharenberg, Andrew M., Piccoli, Mario, Frati, Luigi, Siraganian, Reuben, Santoni, Angela

“…Engagement of the high affinity receptor for IgE (FcεRI) on mast cells and basophils results in FcεRI β and γ subunits ubiquitination by an as yet undefined…”
Get full text

Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells by Ota, Y, Beitz, L O, Scharenberg, A M, Donovan, J A, Kinet, J P, Samelson, L E

“…Tyrosine phosphorylation of the Cbl protooncogene has been shown to occur after engagement of a number of different receptors on hematopoietic cells. However,…”
Get full text

Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1[beta] Inhibition by Goldbach-Mansky, Raphaela, Dailey, Natalie J, Canna, Scott W, Gelabert, Ana, Jones, Janet, Rubin, Benjamin I, Kim, H Jeffrey, Brewer, Carmen, Zalewski, Christopher, Wiggs, Edythe, Hill, Suvimol, Turner, Maria L, Karp, Barbara I, Aksentijevich, Ivona, Pucino, Frank, Penzak, Scott R, Haverkamp, Margje H, Stein, Leonard, Adams, Barbara S, Moore, Terry L, Fuhlbrigge, Robert C, Shaham, Bracha, Jarvis, James N, O'Neil, Kathleen, Vehe, Richard K, Beitz, Laurie O, Gardner, Gregory, Hannan, William P, Warren, Robert W, Horn, William, Cole, Joe L, Paul, Scott M, Hawkins, Philip N, Pham, Tuyet Hang, Snyder, Christopher, Wesley, Robert A, Hoffmann, Steven C, Holland, Steven M, Butman, John A, Kastner, Daniel L

“…Background Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss,…”
Get full text

Activation of Syk Tyrosine Kinase Is Required for c-Cbl-mediated Ubiquitination of FcεRI and Syk in RBL Cells by Rossella Paolini, Rosa Molfetta, Laurie O. Beitz, Juan Zhang, Andrew M. Scharenberg, Mario Piccoli, Luigi Frati, Reuben Siraganian, Angela Santoni

“…Engagement of the high affinity receptor for IgE (FcεRI) on mast cells and basophils results in FcεRI β and γ subunits ubiquitination by an as yet…”
Get full text

Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells by Paolini, Rossella, Molfetta, Rosa, Beitz, Laurie O, Zhang, Juan, Scharenberg, Andrew M, Piccoli, Mario, Frati, Luigi, Siraganian, Reuben, Santoni, Angela

“…Engagement of the high affinity receptor for IgE (FcepsilonRI) on mast cells and basophils results in FcepsilonRI beta and gamma subunits ubiquitination by an…”
Get full text

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition by Goldbach-Mansky, Raphaela, Dailey, Natalie J, Canna, Scott W, Gelabert, Ana, Jones, Janet, Rubin, Benjamin I, Kim, H Jeffrey, Brewer, Carmen, Zalewski, Christopher, Wiggs, Edythe, Hill, Suvimol, Turner, Maria L, Karp, Barbara I, Aksentijevich, Ivona, Pucino, Frank, Penzak, Scott R, Haverkamp, Margje H, Stein, Leonard, Adams, Barbara S, Moore, Terry L, Fuhlbrigge, Robert C, Shaham, Bracha, Jarvis, James N, O'Neil, Kathleen, Vehe, Richard K, Beitz, Laurie O, Gardner, Gregory, Hannan, William P, Warren, Robert W, Horn, William, Cole, Joe L, Paul, Scott M, Hawkins, Philip N, Pham, Tuyet Hang, Snyder, Christopher, Wesley, Robert A, Hoffmann, Steven C, Holland, Steven M, Butman, John A, Kastner, Daniel L

“…Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental…”
Get full text