Search Results - "Beitz, J"
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Inhibition of cytochrome P450c17 reduces spinal astrocyte activation in a mouse model of neuropathic pain via regulation of p38 MAPK phosphorylation
Published in Biomedicine & pharmacotherapy (01-10-2019)“…[Display omitted] •P450c17 inhibition suppresses the activation of spinal astrocytes in CCI mice.•P450c17 inhibition has no effect on the activation of spinal…”
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Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents
Published in Biological & pharmaceutical bulletin (01-02-2018)“…Despite the relatively high prevalence of migraine or headache, the pathophysiological mechanisms triggering headache-associated peripheral hypersensitivities,…”
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Intrathecal interleukin-1β decreases sigma-1 receptor expression in spinal astrocytes in a murine model of neuropathic pain
Published in Biomedicine & pharmacotherapy (01-12-2021)“…The sigma-1 receptor (Sig-1R) plays an important role in spinal pain transmission by increasing phosphorylation of the N-methyl-D-aspartate (NMDA) receptor…”
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Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice
Published in Neuropharmacology (01-12-2016)“…We have previously shown using a spinal cord injury (SCI) model that gap junctions contribute to the early spread of astrocyte activation in the lumbar spinal…”
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Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception
Published in Proceedings of the National Academy of Sciences - PNAS (09-07-2013)“…The low effectiveness of morphine and related mu opioid analgesics for the treatment of chronic inflammatory pain is a result of opioid-induced release of…”
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Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Published in Frontiers in pharmacology (11-12-2023)“…Progesterone has been shown to have neuroprotective capabilities against a wide range of nervous system injuries, however there are negative clinical studies…”
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σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain
Published in British journal of pharmacology (01-12-2014)“…Background and Purpose Spinal astrocytes have emerged as important mechanistic contributors to the genesis of mechanical allodynia (MA) in neuropathic pain. We…”
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Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain
Published in Frontiers in pharmacology (06-12-2019)“…Research indicates that neurosteroids are locally synthesized in the central nervous system and play an important modulatory role in nociception. While the…”
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Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model
Published in European journal of pharmacology (15-11-2014)“…The therapeutic management of chronic pain associated with many cancers is problematic due to the development of tolerance and other adverse effects during the…”
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Clonidine, an alpha‐2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin‐induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension
Published in International journal of cancer (15-05-2016)“…Cancer chemotherapy with platinum‐based antineoplastic agents including oxaliplatin frequently results in a debilitating and painful peripheral neuropathy. We…”
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Spinal Sigma-1 Receptor-mediated Dephosphorylation of Astrocytic Aromatase Plays a Key Role in Formalin-induced Inflammatory Nociception
Published in Neuroscience (21-02-2018)“…•Dephosphorylated aromatase in astrocyte is involved in the process of formalin-induced acute nociception.•Activation of astrocyte sigma-1 receptors is…”
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Differential involvement of ipsilateral and contralateral spinal cord astrocyte D‐serine in carrageenan‐induced mirror‐image pain: role of σ1 receptors and astrocyte gap junctions
Published in British journal of pharmacology (01-02-2018)“…Background and Purpose Although we have recently demonstrated that spinal astrocyte gap junctions mediate the development of mirror‐image pain (MIP), it is…”
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Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats
Published in Pharmacological research (01-08-2013)“…We have recently demonstrated that spinal sigma-1 receptors (Sig-1Rs) mediate pain hypersensitivity in mice and neuropathic pain in rats. In this study, we…”
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Functional Interactions between Tumor and Peripheral Nerve: Morphology, Algogen Identification, and Behavioral Characterization of a New Murine Model of Cancer Pain
Published in The Journal of neuroscience (01-12-2001)“…This paper describes a model of tumor-induced bone destruction and hyperalgesia produced by implantation of fibrosarcoma cells into the mouse calcaneus bone…”
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Spinal Interleukin-1β Inhibits Astrocyte Cytochrome P450c17 Expression Which Controls the Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain
Published in Frontiers in molecular neuroscience (20-06-2019)“…We have recently demonstrated that sciatic nerve injury increases the expression of spinal cytochrome P450c17, a key neurosteroidogenic enzyme, which plays a…”
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Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors
Published in Journal of neurophysiology (01-02-2012)“…The rostral ventromedial medulla (RVM) is part of descending circuitry that modulates nociceptive processing at the level of the spinal cord. RVM output can…”
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Activation of spinal microglia in a murine model of peripheral inflammation-induced, long-lasting contralateral allodynia
Published in Neuroscience letters (25-07-2008)“…Increased sensitivity contralateral to an injury has been described in humans and in various models of neuropathic pain in rats. The mechanism underlying…”
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Intrathecal Injection of the ς1Receptor Antagonist BD1047 Blocks Both Mechanical Allodynia and Increases in Spinal NR1 Expression during the Induction Phase of Rodent Neuropathic Pain
Published in Anesthesiology (Philadelphia) (01-11-2008)“…Background Selective blockade of spinal sigma(1) receptors (Sig-1R) suppresses nociceptive behaviors in the mouse formalin test. The current study was designed…”
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Activation of the spinal sigma‐1 receptor enhances NMDA‐induced pain via PKC‐ and PKA‐dependent phosphorylation of the NR1 subunit in mice
Published in British journal of pharmacology (01-07-2008)“…Background and purpose: Previously we demonstrated that the spinal sigma‐1 receptor (Sig‐1 R) plays an important role in pain transmission, although the exact…”
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Spinal sigma-1 receptor activation increases the production of d-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain
Published in Pharmacological research (01-10-2015)“…[Display omitted] DAAO, d-amino acid oxidase; i.t., intrathecal; LSOS, l-serine O-sulfate potassium salt; NMDA R, N-methyl-d-aspartate receptor; Sig-1R,…”
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