Search Results - "Beinke, Sören"

Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate by Beinke, Sören, Phee, Hyewon, Clingan, Jonathan M., Schlessinger, Joseph, Matloubian, Mehrdad, Weiss, Arthur

“…T-cell interactions with antigen-presenting cells are important for CD8 T-cell effector or memory fate determination. The integrin leukocyte…”
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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection by Aegerter, Helena, Kulikauskaite, Justina, Crotta, Stefania, Patel, Harshil, Kelly, Gavin, Hessel, Edith M., Mack, Matthias, Beinke, Soren, Wack, Andreas

“…Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance…”
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βTrCP-Mediated Proteolysis of NF-κB1 p105 Requires Phosphorylation of p105 Serines 927 and 932 by Lang, Valerie, Janzen, Julia, Fischer, Gregory Zvi, Soneji, Yasmina, Beinke, Sören, Salmeron, Andres, Allen, Hamish, Hay, Ronald T., Ben-Neriah, Yinon, Ley, Steven C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment by Davidson, Sophia, McCabe, Teresa M, Crotta, Stefania, Gad, Hans Henrik, Hessel, Edith M, Beinke, Soren, Hartmann, Rune, Wack, Andreas

“…Influenza A virus (IAV)‐induced severe disease is characterized by infected lung epithelia, robust inflammatory responses and acute lung injury. Since type I…”
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Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection by Groeger, David, Schiavi, Elisa, Grant, Ray, Kurnik-Łucka, Magdalena, Michalovich, David, Williamson, Rick, Beinke, Soren, Kiely, Barry, Akdis, Cezmi A, Hessel, Edith M, Shanahan, Fergus, O’ Mahony, Liam

“…Prophylactic strategies are urgently needed for prevention of severe inflammatory responses to respiratory viral infections. Bacterial-host interactions may…”
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Suppression of inflammation by a synthetic histone mimic by NICODEME, Edwige, JEFFREY, Kate L, WHITE, Julia, KIRILOVSKY, Jorge, RICE, Charles M, LORA, Jose M, PRINJHA, Rab K, LEE, Kevin, TARAKHOVSKY, Alexander, SCHAEFER, Uwe, BEINKE, Soren, DEWELL, Scott, CHUNG, Chun-Wa, CHANDWANI, Rohit, MARAZZI, Ivan, WILSON, Paul, COSTE, Hervé

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Functions of NF-κB1 and NF-κB2 in immune cell biology by BEINKE, Sören, LEY, Steven C.

“…Two members of the NF-κB (nuclear factor κB)/Rel transcription factor family, NF-κB1 and NF-κB2, are produced as precursor proteins, NF-κB1 p105 and NF-κB2…”
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The Death Domain of NF-κB1 p105 Is Essential for Signal-induced p105 Proteolysis by Beinke, Sören, Belich, Monica P., Ley, Steven C.

“…Stimulation of cells with tumor necrosis factor α (TNFα) triggers NF-κB1 p105 proteolysis, releasing associated Rel subunits to translocate into the nucleus…”
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Suppression of inflammation by a synthetic histone mimic by Schaefer, Uwe, Coste, Hervé, Marazzi, Ivan, Dewell, Scott, Kirilovsky, Jorge, Beinke, Soren, Rice, Charles M, Lee, Kevin, Lora, Jose M, Chandwani, Rohit, Chung, Chun-wa, Tarakhovsky, Alexander, Jeffrey, Kate L, Prinjha, Rab K, Nicodeme, Edwige, White, Julia, Wilson, Paul

“…Interaction of pathogens with cells of the immune system results in activation of inflammatory gene expression. This response, although vital for immune…”
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PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K by Malek, Mouhannad, Kielkowska, Anna, Chessa, Tamara, Anderson, Karen E., Barneda, David, Pir, Pınar, Nakanishi, Hiroki, Eguchi, Satoshi, Koizumi, Atsushi, Sasaki, Junko, Juvin, Véronique, Kiselev, Vladimir Y., Niewczas, Izabella, Gray, Alexander, Valayer, Alexandre, Spensberger, Dominik, Imbert, Marine, Felisbino, Sergio, Habuchi, Tomonori, Beinke, Soren, Cosulich, Sabina, Le Novère, Nicolas, Sasaki, Takehiko, Clark, Jonathan, Hawkins, Phillip T., Stephens, Len R.

“…The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P3…”
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PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K by Malek, Mouhannad, Kielkowska, Anna, Chessa, Tamara, Anderson, Karen E, Barneda, David, Pir, Pınar, Nakanishi, Hiroki, Eguchi, Satoshi, Koizumi, Atsushi, Sasaki, Junko, Juvin, Véronique, Kiselev, Vladimir Y, Niewczas, Izabella, Gray, Alexander, Valayer, Alexandre, Spensberger, Dominik, Imbert, Marine, Felisbino, Sergio, Habuchi, Tomonori, Beinke, Soren, Cosulich, Sabina, Le Novère, Nicolas, Sasaki, Takehiko, Clark, Jonathan, Hawkins, Phillip T, Stephens, Len R

“…The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P …”
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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia by Dawson, Mark A., Prinjha, Rab K., Dittmann, Antje, Giotopoulos, George, Bantscheff, Marcus, Chan, Wai-In, Robson, Samuel C., Chung, Chun-wa, Hopf, Carsten, Savitski, Mikhail M., Huthmacher, Carola, Gudgin, Emma, Lugo, Dave, Beinke, Soren, Chapman, Trevor D., Roberts, Emma J., Soden, Peter E., Auger, Kurt R., Mirguet, Olivier, Doehner, Konstanze, Delwel, Ruud, Burnett, Alan K., Jeffrey, Phillip, Drewes, Gerard, Lee, Kevin, Huntly, Brian J. P., Kouzarides, Tony

“…BET proteins as targets in mixed lineage leukaemia Rearrangements of the MLL (mixed lineage leukaemia) gene, and chimaeric MLL-fusion proteins, occur in a…”
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Activation-induced cell protrusions and vesicle secretion of human lung macrophages revealed by super-resolution microscopy by Dechantsreiter, Susanne, Ambrose, Ashley, Hessel, Edith M, Beinke, Soren, Tannahill, Gillian, Davis, Daniel M

“…Recent studies using super-resolution microscopy have established that the organisation of immune cell receptors impacts signal integration and cellular…”
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Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages by Ambrose, Ashley R., Dechantsreiter, Susanne, Shah, Rajesh, Montero, M. Angeles, Quinn, Anne Marie, Hessel, Edith M., Beinke, Soren, Tannahill, Gillian M., Davis, Daniel M.

“…Observing the cell surface and underlying cytoskeleton at nanoscale resolution using super-resolution microscopy has enabled many insights into cell signaling…”
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The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport by Howes, Ashleigh, Rogerson, Clare, Belyaev, Nikolai, Karagyozova, Tina, Rapiteanu, Radu, Fradique, Ricardo, Pellicciotta, Nicola, Mayhew, David, Hurd, Catherine, Crotta, Stefania, Singh, Tanya, Dingwell, Kevin, Myatt, Anniek, Arad, Navot, Hasan, Hikmatyar, Bijlsma, Hielke, Panjwani, Aliza, Vijayan, Vinaya, Young, George, Bridges, Angela, Petit-Frere, Sebastien, Betts, Joanna, Larminie, Chris, Smith, James C, Hessel, Edith M, Michalovich, David, Walport, Louise, Cicuta, Pietro, Powell, Andrew J, Beinke, Soren, Wack, Andreas

“…Single nucelotide polymorphisms (SNPs) at the locus are among the most commonly reported risk alleles associated with chronic obstructive pulmonary disease…”
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Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A) by Seal, Jonathan, Lamotte, Yann, Donche, Frédéric, Bouillot, Anne, Mirguet, Olivier, Gellibert, Françoise, Nicodeme, Edwige, Krysa, Gael, Kirilovsky, Jorge, Beinke, Soren, McCleary, Scott, Rioja, Inma, Bamborough, Paul, Chung, Chun-Wa, Gordon, Laurie, Lewis, Toni, Walker, Ann L., Cutler, Leanne, Lugo, David, Wilson, David M., Witherington, Jason, Lee, Kevin, Prinjha, Rab K.

“…A novel series of quinoline isoxazole BET family bromodomain inhibitors are discussed. Crystallography is used to illustrate binding modes and rationalize…”
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Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures by Wronski, Sabine, Beinke, Soren, Obernolte, Helena, Belyaev, Nikolai N., Saunders, Ken A., Lennon, Mark G., Schaudien, Dirk, Braubach, Peter, Jonigk, Danny, Warnecke, Gregor, Zardo, Patrick, Fieguth, Hans-Gerd, Wilkens, Ludwig, Braun, Armin, Hessel, Edith M., Sewald, Katherina

“…Human rhinovirus (RV) is a major risk factor for chronic obstructive pulmonary disease (COPD) and asthma exacerbations. The exploration of RV pathogenesis has…”
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Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface by Rapiteanu, Radu, Karagyozova, Tina, Zimmermann, Natalie, Singh, Kuljit, Wayne, Gareth, Martufi, Matteo, Belyaev, Nikolai N, Hessel, Edith M, Michalovich, David, Macarron, Ricardo, Rowan, Wendy C, Cairns, William J, Roger, Jan, Betts, Joanna, Beinke, Soren, Maratou, Klio

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Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology by Beinke, Sören, Ley, Steven C

“…Two members of the NF-kappaB (nuclear factor kappaB)/Rel transcription factor family, NF-kappaB1 and NF-kappaB2, are produced as precursor proteins, NF-kappaB1…”
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MAP kinase kinase kinases and innate immunity by Symons, Antony, Beinke, Soren, Ley, Steven C.

“…Toll-like receptors, which respond to invariant microbial molecules, and receptors for the proinflammatory cytokines tumour necrosis factor and interleukin-1…”
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