Search Results - "Beijnen, JH"

Mice Lacking Multidrug Resistance Protein 3 Show Altered Morphine Pharmacokinetics and Morphine-6-Glucuronide Antinociception by Zelcer, Noam, van de Wetering, Koen, Hillebrand, Michel, Sarton, Elise, Kuil, Annemieke, Wielinga, Peter R., Tephly, Thomas, Dahan, Albert, Beijnen, Jos H., Borst, Piet

“…Glucuronidation is a major detoxification pathway for endogenous and exogenous compounds in mammals that results in the intracellular formation of polar…”
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Improvement of Oral Drug Treatment by Temporary Inhibition of Drug Transporters and/or Cytochrome P450 in the Gastrointestinal Tract and Liver: An Overview by Kruijtzer, C.M.F., Beijnen, J.H., Schellens, J.H.M.

“…The oral bioavailability of many cytotoxic drugs is low and/or highly variable. This can be caused by high affinity for drug transporters and activity of…”
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Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice by Bardelmeijer, Heleen A, Ouwehand, Mariët, Beijnen, Jos H, Schellens, Jan H M, van Tellingen, Olaf

“…P-glycoprotein inhibitors can increase the oral bioavailability of paclitaxel. We have now explored the mechanisms that determine the efficacy of several novel…”
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Effects of cytochrome P450 3A (CYP3A) and the drug transporters P‐glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir by van Waterschoot, RAB, ter Heine, R, Wagenaar, E, van der Kruijssen, CMM, Rooswinkel, RW, Huitema, ADR, Beijnen, JH, Schinkel, AH

“…Background and purpose:  Lopinavir is extensively metabolized by cytochrome P450 3A (CYP3A) and is considered to be a substrate for the drug transporters ABCB1…”
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Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin by TERWOGT, Jetske M, GROENEWEGEN, Gerard, BEIJNEN, Jos H, SCHELLENS, Jan H. M, PLUIM, Dick, MALIEPAARD, Marc, TIBBEN, Matthijs M, HUISMAN, Albert, TEN BOKKEL HUININK, Wim W, SCHOT, Margaret, WELBANK, Helen, VOEST, Emile E

“…To investigate the safety and pharmacokinetics of a new liposomal formulation of cisplatin, SPI-77, in patients with advanced malignancies. Patients with…”
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Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin by Kerbusch, Thomas, Jansen, Rob L. H., Mathôt, Ron A. A., Huitema, Alwin D. R., Jansen, Myra, Rijswijk, Ruud E. N., Beijnen, Jos H.

“…Background The autoinducible metabolic transformation of the anticancer agent ifosfamide involves activation through 4‐hydroxyifosfamide to the ultimate…”
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Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies by Keizer, Ron J., Huitema, Alwin D. R., Schellens, Jan H. M., Beijnen, Jos H.

“…Monoclonal antibodies (mAbs) have been used in the treatment of various diseases for over 20 years and combine high specificity with generally low toxicity…”
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Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not? by Stokvis, Ellen, Rosing, Hilde, Beijnen, Jos H.

“…It appears to be a general belief that stable isotopically labeled (SIL) internal standards yield better assay performance results for quantitative…”
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PK PD Model of Indisulam and Capecitabine: Interaction Causes Excessive Myelosuppression by Zandvliet, AS, Siegel‐Lakhai, WS, Beijnen, JH, Copalu, W, Etienne‐Grimaldi, M‐C, Milano, G, Schellens, JHM, Huitema, ADR

“…The anticancer agent indisulam was evaluated in a dose‐escalation study in combination with capecitabine. Severe myelotoxicity was observed after multiple…”
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Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs by Breedveld, Pauline, Beijnen, Jos H., Schellens, Jan H.M.

“…P-glycoprotein (ABCB1) and breast cancer resistance protein [BCRP (also known as ABCG2)] are drug efflux transporters of the ATP binding cassette (ABC) family…”
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Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol by van den Bongard, H J G Desirée, Sparidans, Rolf W, Critchley, David J P, Beijnen, Jos H, Schellens, Jan H M

“…E7070 is a novel sulfonamide anticancer agent that arrests cancer cells at the G1/S boundary of the cell cycle. Three patients receiving chronic therapy with…”
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A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent by RADEMAKER-LAKHAI, Jeany M, VAN DEN BONGARD, Desiree, PLUIM, Dick, BEIJNEN, Jos H, SCHELLENS, Jan H. M

“…Purpose: NAMI-A {H 2 Im[ trans- RuCl 4 (DMSO)HIm] or imidazolium- trans- DMSO-imidazole-tetrachlororuthenate} is a novel ruthenium-containing compound that has…”
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Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization with trans-4′-hydrazino-2-stilbazole by Sparidans, Rolf W., Schellens, Jan H. M., López-Lázaro, Luis, Jimeno, José M., Beijnen, Jos H.

“…A sensitive bio‐analytical assay for the depsipeptide aplidine in plasma has been modified and tested for human whole blood samples. The adapted method is based…”
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Drug interactions in oncology by Beijnen, Jos H, Schellens, Jan H M

“…Drug interactions are an ongoing concern in treatment of cancer, especially when cytotoxic drugs are being used. However, the clinical relevance of these…”
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Pharmacokinetic interaction between rifampin and zidovudine by BURGER, D. M, MEENHORST, P. L, KOKS, C. H. W, BEIJNEN, J. H

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Therapeutic drug monitoring of non-anticancer drugs in cancer patients by JOERGER, M, SCHELLENS, J. H. M, BEIJNEN, J. H

“…Therapeutic drug monitoring (TDM) or the measurement of drug concentrations in plasma, serum or blood, aims to improve clinical activity, avoid toxicity, and…”
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Clinical pharmacokinetics of cyclophosphamide by DE JONGE, Milly E, HUITEMA, Alwin D. R, RODENHUIS, Sjoerd, BEIJNEN, Jos H

“…Cyclophosphamide is an extensively used anticancer and immunosuppressive agent. It is a prodrug undergoing a complicated process of metabolic activation and…”
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Development of Farnesyl Transferase Inhibitors: A Review by Appels, Natalie M.G.M., Beijnen, Jos H., Schellens, Jan H.M.

“…Learning Objectives After completing this course, the reader will be able to: Describe the potential mechanisms by which farnesyl transferases inhibit tumor…”
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The Effects of Fall-Risk-Increasing Drugs on Postural Control: A Literature Review by de Groot, Maartje H., van Campen, Jos P. C. M., Moek, Marije A., Tulner, Linda R., Beijnen, Jos H., Lamoth, Claudine J. C.

“…Meta-analyses showed that psychotropic drugs (antidepressants, neuroleptics, benzodiazepines, antiepileptic drugs) and some cardiac drugs (digoxin, type IA…”
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The Breast Cancer Resistance Protein Protects against a Major Chlorophyll-Derived Dietary Phototoxin and Protoporphyria by Jonker, Johan W., Buitelaar, Marije, Wagenaar, Els, van der Valk, Martin A., Scheffer, George L., Scheper, Rik J., Plösch, Torsten, Kuipers, Folkert, Ronald P.J. Oude Elferink, Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H.

“…The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various…”
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