Search Results - "Beignet, Julien"

Rac1 as a Target to Treat Dysfunctions and Cancer of the Bladder by Sauzeau, Vincent, Beignet, Julien, Bailly, Christian

“…Bladder pathologies, very common in the aged population, have a considerable negative impact on quality of life. Novel targets are needed to design drugs and…”
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Synthesis of a 35-Member Stereoisomer Library of Bistramide A: Evaluation of Effects on actin State, Cell Cycle and Tumor Cell Growth by Wrona, Iwona E, Lowe, Jason T, Turbyville, Thomas J, Johnson, Tanya R, Beignet, Julien, Beutler, John A, Panek, James S

“…Synthesis and preliminary biological evaluation of a 35-member library of bistramide A stereoisomers are reported. All eight stereoisomers of the C1−C13…”
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Rac1 as a therapeutic anticancer target: Promises and limitations by Bailly, Christian, Beignet, Julien, Loirand, Gervaise, Sauzeau, Vincent

“…[Display omitted] •The small GTPase RAC1 is implicated in multiple human pathologies, including cancers.•Rac1 is a ubiquitous protein but frequently…”
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Overexpressed or hyperactivated Rac1 as a target to treat hepatocellular carcinoma by Sauzeau, Vincent, Beignet, Julien, Vergoten, Gérard, Bailly, Christian

“…Despite novel targeted and immunotherapies, the prognosis remains bleak for patients with hepatocellular carcinoma (HCC), especially for advanced and/or…”
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Temporary Silicon Connection Strategies in Intramolecular Allylation of Aldehydes with Allylsilanes by Beignet, Julien, Jervis, Peter J, Cox, Liam R

“…Three γ-(amino)silyl-substituted allylsilanes 14a−c have been prepared in three steps from the corresponding dialkyldichlorosilane. The aminosilyl group has…”
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Stereoselective Synthesis of Allyl-C-mannosyl Compounds:  Use of a Temporary Silicon Connection in Intramolecular Allylation Strategies with Allylsilanes by Beignet, Julien, Tiernan, James, Woo, Chang H, Kariuki, Benson M, Cox, Liam R

“…Methyl mannoside 16 containing an allyldimethylsilyl ether at C(2) was synthesized in nine steps from d-mannose. Reaction with TMSOTf in MeCN at…”
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Using a Temporary Silicon Connection in Stereoselective Allylation with Allylsilanes:  Application to the Synthesis of Stereodefined 1,2,4-Triols by Beignet, Julien, Cox, Liam R

“…Treatment of aldehyde 6 with TMSOTf, in the presence of a Brønsted acid scavenger, effects an intramolecular allylation to provide the oxasilacycle 7 as the…”
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Stereoselective Synthesis of Allyl-C-mannosyl Compounds:  Use of a Temporary Silicon Connection in Intramolecular Allylation Strategies with Allylsilanes by Beignet, Julien, Tiernan, James, Woo, Chang H, Kariuki, Benson M, Cox, Liam R

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