Search Results - "Beigelman, L."

Short duration treatment with AL-335 and odalasvir, with or without simeprevir, in treatment naïve patients with hepatitis C infection with or without cirrhosis by Gane, E, Stedman, C, McClure, M, Apelian, D, Westland, C, Vuong, J, Patel, M, Kakuda, T, Chanda, S, Blatt, L, Beigelman, L, Smith, D, Fry, J

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AL-335, a Once-Daily Pangenotypic Nucleotide HCV Polymerase Inhibitor, Demonstrates Potent Antiviral Activity over 7 Days in Treatment-Naïve Genotype 1-4 Patients by Berliba, E, Tsertsvadze, T, Ghicavii, N, Guyader, D, Kakabadze, T, Westland, C, Chanda, S, Patat, A, Zhang, Q, Smith, D, Yogaratnam, J, McClure, M, Beigelman, L, Blatt, L, Fry, J

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Pan-Genotypic Evaluation of AL-335, a Clinical Stage Uridine Analogue Inhibitor of Hepatitis C Virus Polymerase by Deval, J, Fung, A, Behera, I, Jin, Z, Stoycheva, A, Blatt, L.M, Wang, G, Dyatkina, N, Prhavc, M, Symons, J.A, Smith, D.B, Beigelman, L

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P0679 : Derisking the potential for mitochondrial toxicity of nucleoside analogs by Jin, Z, Deval, J, Symons, J.A, Tan, H, Shaw, K, Chanda, S.M, Zhang, Q, Tam, Y, Blatt, L.M, Wang, G, Dyatkina, N, Beigelman, L, Smith, D.B

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P0682 : Preclinical characterization of AL-335, a potent uridine based nucleoside polymerase inhibitor for the treatment of chronic hepatitis C by Tan, H, Shaw, K, Jekel, A, Deval, J, Jin, Z, Fung, A, Tam, Y, Blatt, L.M, Chanda, S.M, Wang, G, Prhavc, M, Serebryany, V, Zhang, Q, Symons, J.A, Beigelman, L, Smith, D.B

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1222 IN VITRO RESISTANCE TO ALS-2200, A POTENT NUCLEOTIDE POLYMERASE INHIBITOR FOR THE TREATMENT OF CHRONIC HEPATITIS C by Tan, H, Jekle, A, Kang, H, Moy, C, Deval, J, Tigges, A, Zhang, E, Jiang, M, Andzinski, A, Dyatkina, N, Wang, G, Rijnbrand, R, Kieffer, T.L, Blatt, L.M, Beigelman, L, Smith, D.B, Symons, J.A

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1219 VX-135, A POTENT SINGLE DIASTEREOMER OF ALS-2200, FOR THE TREATMENT OF CHRONIC HEPATITIS C by Tan, H, Deval, J, Kang, H, Moy, C, Jin, Z, Jiang, M, Ardzinski, A, Rijnbrand, R, Kieffer, T, Blatt, L.M, Chanda, S.M, Dyatkina, N, Wang, G, Zhang, Q, Symons, J.A, Beigelman, L, Smith, D.B

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866 ALS-2200, A NOVEL ONCE-DAILY NUCLEOTIDE HCV POLYMERASE INHIBITOR, DEMONSTRATED POTENT ANTIVIRAL ACTIVITY IN TREATMENT-NAÏVE PATIENTS WITH COMPENSATED CIRRHOSIS OR GENOTYPE 2–4 CHRONIC HEPATITIS C by Marcellin, P, Popa, S, Streinu-Cercel, A, Boyer, N, Dospinoiu, D, Patat, A, Ghicavii, N, Garg, V, Kauffman, R.S, Koziel, M, Tong, M.J, Chanda, S, Zhang, Q, Westland, C, Beigelman, L, Blatt, L.M, Fry, J

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19 DEVELOPMENT OF NOVEL HYPERGLYGOSYLATED TYPE 1 INTERFERONS: A STRATEGY TO IMPROVE PK PERFORMANCE WITHOUT LOSS OF BIOLOGICAL POTENCY by Blatt, L.M, Seiwert, S, Beigelman, L

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Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance by Beigelman, L, McSwiggen, J A, Draper, K G, Gonzalez, C, Jensen, K, Karpeisky, A M, Modak, A S, Matulic-Adamic, J, DiRenzo, A B, Haeberli, P

“…A systematic study of selectively modified, 36-mer hammerhead ribozymes has resulted in the identification of a generic, catalytically active and nuclease…”
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Rescue of Abasic Hammerhead Ribozymes by Exogenous Addition of Specific Bases by Peracchi, Alessio, Beigelman, Leonid, Usman, Nassim, Herschlag, Daniel

“…We have synthesized 13 hammerhead ribozyme variants, each containing an abasic residue at a specific position of the catalytic core. The activity of each of…”
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936 COMBINATION OF THE NS3/4A PROTEASE INHIBITOR ITMN-191 WITH THE ALLOSTERIC NS5B POLYMERASE INHIBITOR ITMN-8020 ENHANCES REPLICON CLEARANCE AND REDUCES THE EMERGENCE OF DRUG RESISTANT VARIANTS by Tan, H, Wang, G, Moy, C, Kossen, K, Rajagopalan, R, Misialek, S, Ruhrmund, D, Hooi, L, Snarskaya, N, Stoycheva, A, Buckman, B, Seiwert, S, Beigelman, L

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938 DISCOVERY OF POTENT, BIOAVAILABLE HCV NS3/4A INHIBITORS THAT DISPLAY UNIMPAIRED ACTIVITY AGAINST AN NS3 SEQUENCE VARIANT ASSOCIATED WITH RESISTANCE TO LINEAR TETRAPEPTIDES AND MACROCYCLIC INHIBITORS by Buckman, B, Kossen, K, Ruhrmund, D, Rajagopalan, R, Stevens, S, Hooi, L, Snarskaya, L, Wang, T, Hong, J, Lim, S, Pan, L, Huang, L, Stoycheva, N, Beigelman, L, Seiwert, S

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Synthesis of 2′-O-Substituted Ribonucleosides by Serebryany, V., Beigelman, L.

“…An efficient synthesis of 2′-O-substituted ribonucleosides, including 2′-O-TBDMS and 2′-O-TOM protected as well as 2′-O-Me and 2′-O-allyl derivatives is…”
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Base and Sugar Requirements for RNA Cleavage of Essential Nucleoside Residues in Internal Loop B of the Hairpin Ribozyme: Implications for Secondary Structure by Schmidt, Sabine, Beigelman, Leonid, Karpeisky, Alexander, Usman, Nassim, Sørensen, Ulrik S., Gait, Michael J.

“…The hairpin ribozyme is a small self-cleaving RNA that can be engineered for RNA cleavage in trans and has potential as a therapeutic agent. We have used a…”
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Synthesis of 1,4-Anhydro-2-deoxy-D-ribitol Derivatives from Thymidine by Serebryany, V., Beigelman, L.

“…1,2-Dideoxyribose 5-O-succinate, a component of solid support employed in the synthesis of ribozymes, was synthesized from thymidine. The key step was…”
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Characterization of nuclease-resistant ribozymes directed against hepatitis B virus RNA by Morrissey, D. V., Lee, P. A., Johnson, D. A., Overly, S. L., McSwiggen, J. A., Beigelman, L., Mokler, V. R., Maloney, L., Vargeese, C., Bowman, K., O'Brien, J. T., Shaffer, C. S., Conrad, A., Schmid, P., Morrey, J. D., Macejak, D. G., Pavco, P. A., Blatt, L. M.

“…Hepatitis B virus (HBV) is responsible for > 350 million cases of chronic hepatitis B worldwide and 1.2 million deaths each year. To explore the use of…”
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Nuclease-Resistant Ribozymes Decrease Stromelysin mRNA Levels in Rabbit Synovium Following Exogenous Delivery to the Knee Joint by Flory, Craig M., Pavco, Pamela A., Jarvis, Thale C., Lesch, Mark E., Wincott, Francine E., Beigelman, Leonid, Hunt, Stephen W., Schrier, Denis J.

“…Catalytic RNA molecules, or ribozymes, have generated significant interest as potential therapeutic agents for controlling gene expression. Although ribozymes…”
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An Improved Synthesis of Inosine 3′-Phosphoramidite by Matulic-Adamic, Jasenka, Beigelman, Leonid

“…A protocol for the efficient conversion of inosine into its 3′-phosphoramidite synthon for solid phase oligonucleotide synthesis has been developed…”
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Photophysical and photochemical properties of C-linked ribosides of pyridin-2-one by Wenska, G, Skalski, B, Gdaniec, Z, Adamiak, R.W, Matulic-Adamic, J, Beigelman, L

“…Absorption and emission properties as well as photochemical behavior of C-ribosides bearing pyridone as the aglycone, namely 5-(β-…”
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