Search Results - "Beierle, John M."
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Temperature-Responsive "Catch and Release" of Proteins by using Multifunctional Polymer-Based Nanoparticles
Published in Angewandte Chemie International Edition (05-03-2012)“…Catch me if you can: Multifunctional, polymer‐based nanoparticles that are capable of temperature‐responsive “catch‐and‐release” of a target protein have been…”
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2
Autoamplification of Molecular Chirality through the Induction of Supramolecular Chirality
Published in Angewandte Chemie International Edition (12-05-2014)“…The novel concept for the autoamplification of molecular chirality, wherein the amplification proceeds through the induction of supramolecular chirality, is…”
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3
Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides
Published in Angewandte Chemie (International ed.) (01-01-2009)“…Fooling enzymes with mock amides: Analogues of apicidin, a cyclic-tetrapeptide inhibitor of histone deacetylase (HDAC), were designed with a 1,4- or…”
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4
Self-Assembling Sequence-Adaptive Peptide Nucleic Acids
Published in Science (American Association for the Advancement of Science) (03-07-2009)“…Several classes of nucleic acid analogs have been reported, but no synthetic informational polymer has yet proven responsive to selection pressures under…”
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5
Light–induced disassembly of self-assembled vesicle-capped nanotubes observed in real time
Published in Nature nanotechnology (14-08-2011)“…Molecular self-assembly is the basis for the formation of numerous artificial nanostructures 1 , 2 . The self-organization of peptides 3 , 4 , 5 , 6 ,…”
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Epitope Discovery for a Synthetic Polymer Nanoparticle: A New Strategy for Developing a Peptide Tag
Published in Journal of the American Chemical Society (29-01-2014)“…We describe a novel epitope discovery strategy for creating an affinity agent/peptide tag pair. A synthetic polymer nanoparticle (NP) was used as the “bait” to…”
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Conformationally Homogeneous Heterocyclic Pseudotetrapeptides as Three‐Dimensional Scaffolds for Rational Drug Design: Receptor‐Selective Somatostatin Analogues
Published in Angewandte Chemie International Edition (01-01-2009)“…A would‐be amide: A 1,4‐disubstituted 1,2,3‐triazole was used as a surrogate for a trans amide bond to create a library of 16 diastereomeric…”
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Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
Published in Chemical reviews (14-08-2013)“…Issues surrounding the reversible photocontrol of biological systems by the incorporation of molecular photoswitches are examined. Photoswitches are used for…”
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Dynamic polythioesters via ring-opening polymerization of 1,4-thiazine-2,5-diones
Published in Organic & biomolecular chemistry (01-01-2009)“…We describe the preparation and characterization of polythioesters composed of alternating alpha-amino acid and alpha-thioglycolic acid residues that undergo…”
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10
A Fast-Moving [2]Rotaxane Whose Stoppers Are Remote from the Copper Complex Core
Published in Organic letters (22-12-2005)“…A new copper-complexed rotaxane is described. It consists of a two-coordination site ring threaded by a sterically non-hindering 2,2‘-bipyridine derivative. An…”
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11
Templated Self-Assembly of Dynamic Peptide Nucleic Acids
Published in Biochemistry (Easton) (09-01-2018)“…Template-directed macromolecule synthesis is a hallmark of living systems. Inspired by this natural process, several fundamentally novel mechanisms for…”
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Polymer Nanoparticle Hydrogels with Autonomous Affinity Switching for the Protection of Proteins from Thermal Stress
Published in Angewandte Chemie International Edition (25-08-2014)“…We report a new material design concept for synthetic, thermally responsive poly(N‐isopropylacrylamide)‐based copolymer nanoparticle (NP) hydrogels, which…”
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13
Metal-Free Polymer-Based Affinity Medium for Selective Purification of His6-Tagged Proteins
Published in Biomacromolecules (12-04-2021)“…We report a metal free synthetic hydrogel copolymer with affinity and selectivity for His6-tagged peptides and proteins. Small libraries of copolymers…”
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Design, Synthesis, Biological Evaluation, and Structural Characterization of Potent Histone Deacetylase Inhibitors Based on Cyclic α/β-Tetrapeptide Architectures
Published in Journal of the American Chemical Society (04-03-2009)“…Histone deacetylases (HDACs) are a family of enzymes found in bacteria, fungi, plants, and animals that profoundly affect cellular function by catalyzing the…”
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15
Autoamplification of Molecular Chirality through the Induction of Supramolecular Chirality
Published in Angewandte Chemie (12-05-2014)“…The novel concept for the autoamplification of molecular chirality, wherein the amplification proceeds through the induction of supramolecular chirality, is…”
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16
An Improved Method for Site-Specific End Modification of Zeolite L for the Formation of Zeolite L and Gold Nanoparticle Self-Assembled Structures
Published in Particle & particle systems characterization (01-03-2013)“…The ability to site‐selectively modify micro‐ and nanosized particles has allowed for directed self‐assembly in two and three dimensions. Site‐selective…”
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Polymer Nanoparticle Hydrogels with Autonomous Affinity Switching for the Protection of Proteins from Thermal Stress
Published in Angewandte Chemie (25-08-2014)“…We report a new material design concept for synthetic, thermally responsive poly(N‐isopropylacrylamide)‐based copolymer nanoparticle (NP) hydrogels, which…”
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18
Temperature-Responsive "Catch and Release" of Proteins by using Multifunctional Polymer-Based Nanoparticles
Published in Angewandte Chemie (05-03-2012)“…Fang mich doch! Multifunktionelle polymerbasierte Nanopartikel wurden synthetisiert, die Zielproteine reversibel und temperaturgesteuert einfangen und wieder…”
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19
Synthesis of Louisianin C
Published in Journal of organic chemistry (13-06-2003)“…The synthesis of louisianin C (3), a member of a small family of 3,4,5-trisubstituted pyridyl natural products, is achieved in six steps and 11% overall yield…”
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20
Temperature‐Responsive “Catch and Release” of Proteins by using Multifunctional Polymer‐Based Nanoparticles
Published in Angewandte Chemie (05-03-2012)Get full text
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