Search Results - "Beier, Kevin"

Modified viral-genetic mapping reveals local and global connectivity relationships of ventral tegmental area dopamine cells by Beier, Kevin

“…Dopamine cells in the ventral tegmental area (VTA ) are critical for a variety of motivated behaviors. These cells receive synaptic inputs from over 100…”
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Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping by Beier, Kevin T., Steinberg, Elizabeth E., DeLoach, Katherine E., Xie, Stanley, Miyamichi, Kazunari, Schwarz, Lindsay, Gao, Xiaojing J., Kremer, Eric J., Malenka, Robert C., Luo, Liqun

“…Dopamine (DA) neurons in the midbrain ventral tegmental area (VTA) integrate complex inputs to encode multiple signals that influence motivated behaviors via…”
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Can transsynaptic viral strategies be used to reveal functional aspects of neural circuitry? by Rogers, Alexandra, Beier, Kevin T.

“…•One-step RABV mapping does not recapitulate key aspects of functional connectivity.•Viruses label only a small fraction of the inputs onto first-order…”
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A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins by François, Amaury, Low, Sarah A., Sypek, Elizabeth I., Christensen, Amelia J., Sotoudeh, Chaudy, Beier, Kevin T., Ramakrishnan, Charu, Ritola, Kimberly D., Sharif-Naeini, Reza, Deisseroth, Karl, Delp, Scott L., Malenka, Robert C., Luo, Liqun, Hantman, Adam W., Scherrer, Grégory

“…Pain thresholds are, in part, set as a function of emotional and internal states by descending modulation of nociceptive transmission in the spinal cord…”
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Hitchhiking on the neuronal highway: Mechanisms of transsynaptic specificity by Beier, Kevin T.

“…•Discuss what is known and unknown about the mechanisms of transsynaptic specificity.•Examine how viruses can label either inputs and/or outputs of starter…”
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Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits by Lerner, Talia N., Shilyansky, Carrie, Davidson, Thomas J., Evans, Kathryn E., Beier, Kevin T., Zalocusky, Kelly A., Crow, Ailey K., Malenka, Robert C., Luo, Liqun, Tomer, Raju, Deisseroth, Karl

“…Recent progress in understanding the diversity of midbrain dopamine neurons has highlighted the importance—and the challenges—of defining mammalian neuronal…”
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Control of REM sleep by ventral medulla GABAergic neurons by Weber, Franz, Chung, Shinjae, Beier, Kevin T., Xu, Min, Luo, Liqun, Dan, Yang

“…Activation of GABAergic neurons in the ventral medulla can reliably induce REM sleep and prolong the duration of REM episodes in mice. Control of REM sleep…”
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5-HT modulation of a medial septal circuit tunes social memory stability by Wu, Xiaoting, Morishita, Wade, Beier, Kevin T., Heifets, Boris D., Malenka, Robert C.

“…Social memory—the ability to recognize and remember familiar conspecifics—is critical for the survival of an animal in its social group 1 , 2 . The dorsal CA2…”
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Gating of social reward by oxytocin in the ventral tegmental area by Hung, Lin W., Neuner, Sophie, Polepalli, Jai S., Beier, Kevin T., Wright, Matthew, Walsh, Jessica J., Lewis, Eastman M., Luo, Liqun, Deisseroth, Karl, Dölen, Gül, Malenka, Robert C.

“…The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral…”
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Viral-genetic tracing of the input–output organization of a central noradrenaline circuit by Schwarz, Lindsay A., Miyamichi, Kazunari, Gao, Xiaojing J., Beier, Kevin T., Weissbourd, Brandon, DeLoach, Katherine E., Ren, Jing, Ibanes, Sandy, Malenka, Robert C., Kremer, Eric J., Luo, Liqun

“…To better understand the relationship between input and output connectivity for neurons of interest in specific brain regions, a viral-genetic tracing approach…”
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Prefrontal cortical regulation of REM sleep by Hong, Jiso, Lozano, David E., Beier, Kevin T., Chung, Shinjae, Weber, Franz

“…Rapid eye movement (REM) sleep is accompanied by intense cortical activity, underlying its wake-like electroencephalogram. The neural activity inducing REM…”
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Regulation of REM and Non-REM Sleep by Periaqueductal GABAergic Neurons by Weber, Franz, Hoang Do, Johnny Phong, Chung, Shinjae, Beier, Kevin T., Bikov, Mike, Saffari Doost, Mohammad, Dan, Yang

“…Mammalian sleep consists of distinct rapid eye movement (REM) and non-REM (NREM) states. The midbrain region ventrolateral periaqueductal gray (vlPAG) is known…”
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Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers by Xu, Xiangmin, Holmes, Todd C., Luo, Min-Hua, Beier, Kevin T., Horwitz, Gregory D., Zhao, Fei, Zeng, Wenbo, Hui, May, Semler, Bert L., Sandri-Goldin, Rozanne M.

“…Viral tracers are important tools for neuroanatomical mapping and genetic payload delivery. Genetically modified viruses allow for cell-type-specific targeting…”
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Identification of preoptic sleep neurons using retrograde labelling and gene profiling by Chung, Shinjae, Weber, Franz, Zhong, Peng, Tan, Chan Lek, Nguyen, Thuc Nghi, Beier, Kevin T., Hörmann, Nikolai, Chang, Wei-Cheng, Zhang, Zhe, Do, Johnny Phong, Yao, Shenqin, Krashes, Michael J., Tasic, Bosiljka, Cetin, Ali, Zeng, Hongkui, Knight, Zachary A., Luo, Liqun, Dan, Yang

“…Identification of sleep-active and sleep-promoting neurons in the preoptic area of the hypothalamus using neural projection tracing tools to target this…”
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Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning by Steinberg, Elizabeth E., Gore, Felicity, Heifets, Boris D., Taylor, Madison D., Norville, Zane C., Beier, Kevin T., Földy, Csaba, Lerner, Talia N., Luo, Liqun, Deisseroth, Karl, Malenka, Robert C.

“…The central amygdala (CeA) orchestrates adaptive responses to emotional events. While CeA substrates for defensive behaviors have been studied extensively, CeA…”
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Defining the interconnectivity of the medial prefrontal cortex and ventral midbrain by Hui, May, Beier, Kevin T.

“…Dysfunction in dopamine (DA) signaling contributes to neurological disorders ranging from drug addiction and schizophrenia to depression and Parkinson’s…”
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Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons by Smith, Jennifer, Honig-Frand, Adam, Antila, Hanna, Choi, Ashley, Kim, Hannah, Beier, Kevin T, Weber, Franz, Chung, Shinjae

“…Sleep disturbances are detrimental to our behavioral and emotional well-being. Stressful events disrupt sleep, in particular by inducing brief awakenings…”
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Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction by Chen, Yun-Hsuan, Yang, Jie, Wu, Hemmings, Beier, Kevin T, Sawan, Mohamad

“…Achieving abstinence from drugs is a long journey and can be particularly challenging in the case of methamphetamine, which has a higher relapse rate than…”
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Topological Organization of Ventral Tegmental Area Connectivity Revealed by Viral-Genetic Dissection of Input-Output Relations by Beier, Kevin T., Gao, Xiaojing J., Xie, Stanley, DeLoach, Katherine E., Malenka, Robert C., Luo, Liqun

“…Viral-genetic tracing techniques have enabled mesoscale mapping of neuronal connectivity by teasing apart inputs to defined neuronal populations in regions…”
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Integrated anatomical and physiological mapping of striatal afferent projections by Choi, Kyuhyun, Holly, Elizabeth N., Davatolhagh, M. Felicia, Beier, Kevin T., Fuccillo, Marc V.

“…The dorsomedial striatum, a key site of reward‐sensitive motor output, receives extensive afferent input from cortex, thalamus and midbrain. These projections…”
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