Search Results - "Beier, H."

Welding residual stresses as needed for the prediction of fatigue crack propagation and fatigue strength by Hensel, J., Nitschke-Pagel, T., Tchoffo Ngoula, D., Beier, H.-Th, Tchuindjang, D., Zerbst, U.

“…•Discussion of general mechanisms of welding residual stress generation and their relaxation behavior under fatigue loading.•Residual stress effects on crack…”
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The IBESS model – Elements, realisation and validation by Madia, M., Zerbst, U., Th. Beier, H., Schork, B.

“…•Fracture mechanics-based fatigue strength assessment of welded joints.•Modelling of short crack propagation with focus on crack closure effects.•Modelling of…”
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Helios expression is a marker of T cell activation and proliferation by Akimova, Tatiana, Beier, Ulf H, Wang, Liqing, Levine, Matthew H, Hancock, Wayne W

“…Foxp3+ T-regulatory cells (Tregs) normally serve to attenuate immune responses and are key to maintenance of immune homeostasis. Over the past decade, Treg…”
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Sirtuin‐1 in immunotherapy: A Janus‐headed target by Chadha, Sakshum, Wang, Liqing, Hancock, Wayne W., Beier, Ulf H.

“…Sirtuin‐1 (Sirt1), a member of the NAD‐dependent sirtuin family of histone/protein deacetylases (HDAC), is an important target for immunotherapy due to its…”
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Lactate Limits T Cell Proliferation via the NAD(H) Redox State by Quinn, William J., Jiao, Jing, TeSlaa, Tara, Stadanlick, Jason, Wang, Zhonglin, Wang, Liqing, Akimova, Tatiana, Angelin, Alessia, Schäfer, Patrick M., Cully, Michelle D., Perry, Caroline, Kopinski, Piotr K., Guo, Lili, Blair, Ian A., Ghanem, Louis R., Leibowitz, Michael S., Hancock, Wayne W., Moon, Edmund K., Levine, Matthew H., Eruslanov, Evgeniy B., Wallace, Douglas C., Baur, Joseph A., Beier, Ulf H.

“…Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor…”
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Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function by Huang, Jianbing, Wang, Liqing, Dahiya, Satinder, Beier, Ulf H., Han, Rongxiang, Samanta, Arabinda, Bergman, Joel, Sotomayor, Eduardo M., Seto, Edward, Kozikowski, Alan P., Hancock, Wayne W.

“…Current interest in Foxp3+ T-regulatory (Treg) cells as therapeutic targets in transplantation is largely focused on their harvesting pre-transplant, expansion…”
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Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells by de Zoeten, Edwin F., Wang, Liqing, Butler, Kyle, Beier, Ulf H., Akimova, Tatiana, Sai, Hong, Bradner, James E., Mazitschek, Ralph, Kozikowski, Alan P., Matthias, Patrick, Hancock, Wayne W.

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Sirtuin-1 Targeting Promotes Foxp3+ T-Regulatory Cell Function and Prolongs Allograft Survival by Beier, Ulf H., Wang, Liqing, Bhatti, Tricia R., Liu, Yujie, Han, Rongxiang, Ge, Guanghui, Hancock, Wayne W.

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Review on fracture and crack propagation in weldments – A fracture mechanics perspective by Zerbst, U., Ainsworth, R.A., Beier, H.Th, Pisarski, H., Zhang, Z.L., Nikbin, K., Nitschke-Pagel, T., Münstermann, S., Kucharczyk, P., Klingbeil, D.

“…•Comprehensive review on fracture mechanics application to weldments.•Discussion of recent developments in areas such as materials testing, strength mismatch…”
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MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity by Di Giorgio, Eros, Wang, Liqing, Xiong, Yan, Akimova, Tatiana, Christensen, Lanette M, Han, Rongxiang, Samanta, Arabinda, Trevisanut, Matteo, Bhatti, Tricia R, Beier, Ulf H, Hancock, Wayne W

“…The transcription factor MEF2D is important in the regulation of differentiation and adaptive responses in many cell types. We found that among T cells, MEF2D…”
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Mbd2 Promotes Foxp3 Demethylation and T-Regulatory-Cell Function by Wang, Liqing, Liu, Yujie, Han, Rongxiang, Beier, Ulf H., Thomas, Rajan M., Wells, Andrew D., Hancock, Wayne W.

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Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs by Beier, H, Grimm, M

“…Translational stop codon readthrough provides a regulatory mechanism of gene expression that is extensively utilised by positive-sense ssRNA viruses. The…”
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Distinct Bioenergetic Features of Human Invariant Natural Killer T Cells Enable Retained Functions in Nutrient-Deprived States by Khurana, Priya, Burudpakdee, Chakkapong, Grupp, Stephan A, Beier, Ulf H, Barrett, David M, Bassiri, Hamid

“…Invariant natural killer T (iNKT) cells comprise a unique subset of lymphocytes that are primed for activation and possess innate NK-like functional features…”
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A model for fracture mechanics based prediction of the fatigue strength: Further validation and limitations by Zerbst, U., Madia, M., Beier, H.Th

“…•Analytical fracture mechanics model for predicting the finite life fatigue strength of components.•Validation exercises based on literature data show…”
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Targeting Sirtuin-1 prolongs murine renal allograft survival and function by Levine, Matthew H, Wang, Zhonglin, Xiao, Haiyan, Jiao, Jing, Wang, Liqing, Bhatti, Tricia R, Hancock, Wayne W, Beier, Ulf H

“…Current immunosuppressive medications used after transplantation have significant toxicities. Foxp3(+) T-regulatory cells can prevent allograft rejection…”
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HDAC inhibitor therapy in autoimmunity and transplantation by Hancock, Wayne W, Akimova, Tatiana, Beier, Ulf H, Liu, Yujie, Wang, Liqing

“…Pharmacological inhibitors of histone/protein deacetylases (HDACi) have considerable therapeutic potential as anti-inflammatory and immunosuppressive drugs…”
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Pharmacokinetics of inhaled colistin in patients with cystic fibrosis by Ratjen, F., Rietschel, E., Kasel, D., Schwiertz, R., Starke, K., Beier, H., van Koningsbruggen, S., Grasemann, H.

“…Objectives: Inhaled colistin is commonly used in patients with cystic fibrosis (CF), but only limited data are available to define its pharmacokinetic profile…”
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A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells by Di Giorgio, Eros, Wang, Liqing, Xiong, Yan, Christensen, Lanette M, Akimova, Tatiana, Han, Rongxiang, Samanta, Arabinda, Trevisanut, Matteo, Brancolini, Claudio, Beier, Ulf H, Hancock, Wayne W

“…The Mads/Mef2 (Mef2a/b/c/d) family of transcription factors (TFs) regulates differentiation of muscle cells, neurons and hematopoietic cells. By functioning in…”
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HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury by Aufhauser, David D., Hernandez, Paul, Concors, Seth J., O’Brien, Ciaran, Wang, Zhonglin, Murken, Douglas R., Samanta, Arabinda, Beier, Ulf H., Krumeich, Lauren, Bhatti, Tricia R., Wang, Yanfeng, Ge, Guanghui, Wang, Liqing, Cheraghlou, Shayan, Wagner, Florence F., Holson, Edward B., Kalin, Jay H., Cole, Philip A., Hancock, Wayne W., Levine, Matthew H.

“…Histone/protein deacetylases (HDAC) 1 and 2 are typically viewed as structurally and functionally similar enzymes present within various co-regulatory…”
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Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity by Wang, Liqing, Kumar, Suresh, Dahiya, Satinder, Wang, Feng, Wu, Jian, Newick, Kheng, Han, Rongxiang, Samanta, Arabinda, Beier, Ulf H., Akimova, Tatiana, Bhatti, Tricia R., Nicholson, Benjamin, Kodrasov, Mathew P., Agarwal, Saket, Sterner, David E., Gu, Wei, Weinstock, Joseph, Butt, Tauseef R., Albelda, Steven M., Hancock, Wayne W.

“…Foxp3+ T-regulatory (Treg) cells are known to suppress protective host immune responses to a wide variety of solid tumors, but their therapeutic targeting is…”
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