Search Results - "Beier, Eric"

Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration by Neal, Matthew L., Fleming, Sheila M., Budge, Kevin M., Boyle, Alexa M., Kim, Chunki, Alam, Gelareh, Beier, Eric E., Wu, Long‐Jun, Richardson, Jason R.

“…Increased pro‐inflammatory cytokine levels and proliferation of activated microglia have been found in Parkinson's disease (PD) patients and animal models of…”
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Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide by Beier, Eric E., Neal, Matthew, Alam, Gelerah, Edler, Melissa, Wu, Long-Jun, Richardson, Jason R.

“…Inflammation arising from central and/or peripheral sources contributes to the pathogenesis of multiple neurodegenerative diseases including Parkinson's…”
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High-Fat Diet Causes Bone Loss in Young Mice by Promoting Osteoclastogenesis Through Alteration of the Bone Marrow Environment by Shu, Lei, Beier, Eric, Sheu, Tzong, Zhang, Hengwei, Zuscik, Michael J., Puzas, Edward J., Boyce, Brendan F., Mooney, Robert A., Xing, Lianping

“…Obesity is a severe health problem in children, afflicting several organ systems including bone. However, the role of obesity on bone homeostasis and bone cell…”
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Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice by Beier, Eric E, Inzana, Jason A, Sheu, Tzong-Jen, Shu, Lei, Puzas, J Edward, Mooney, Robert A

“…Lead (Pb) exposure and obesity are co-occurring risk factors for decreased bone mass in the young, particularly in low socioeconomic communities. The goal of…”
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Neonatal hyperoxia impairs adipogenesis of bone marrow-derived mesenchymal stem cells and fat accumulation in adult mice by Woeller, Collynn F., Lim, Sydney A., Roztocil, Elisa, Yee, Min, Beier, Eric E., Puzas, J. Edward, O'Reilly, Michael A.

“…Preterm birth is a risk factor for growth failure and development of respiratory disease in children and young adults. Their early exposure to oxygen may…”
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Elevated Lifetime Lead Exposure Impedes Osteoclast Activity and Produces an Increase in Bone Mass in Adolescent Mice by Beier, Eric E, Holz, Jonathan D, Sheu, Tzong-Jen, Puzas, J Edward

“…The heavy metal lead (Pb) has a deleterious effect on skeletal health. Because bone mass is maintained through a balance of bone formation and resorption, it…”
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Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling by Beier, Eric E, Maher, Jason R, Sheu, Tzong-Jen, Cory-Slechta, Deborah A, Berger, Andrew J, Zuscik, Michael J, Puzas, J Edward

“…Exposure to lead (Pb) from environmental and industrial sources remains an overlooked serious public health risk. Elucidating the effect of Pb on bone cell…”
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Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/β-CATENIN SIGNALING PATHWAY by Beier, Eric E, Sheu, Tzong-Jen, Dang, Deborah, Holz, Jonathan D, Ubayawardena, Resika, Babij, Philip, Puzas, J Edward

“…Exposure to lead (Pb) from environmental sources remains an overlooked and serious public health risk. Starting in childhood, Pb in the skeleton can disrupt…”
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Inhibition of beta-catenin signaling by Pb leads to incomplete fracture healing by Beier, Eric E., Sheu, Tzong-jen, Buckley, Taylor, Yukata, Kiminori, O'Keefe, Regis, Zuscik, Michael J., Puzas, J. Edward

“…ABSTRACT There is strong evidence in the clinical literature to suggest that elevated lead (Pb) exposure impairs fracture healing. Since Pb has been…”
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Voltage-Gated Proton Channel Hv1 Regulates Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson's Disease Models by Neal, Matthew L, Beier, Eric E, Hossain, Muhammad M, Boyle, Alexa, Zheng, Jiaying, Kim, Chunki, Mhatre-Winters, Isha, Wu, Long-Jun, Richardson, Jason R

“…Although the precise mechanisms for neurodegeneration in Parkinson's disease (PD) are unknown, evidence suggests that neuroinflammation is a critical factor in…”
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Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice by Beier, Eric E, Sheu, Tzong-Jen, Resseguie, Emily A, Takahata, Masahiko, Awad, Hani A, Cory-Slechta, Deborah A, Puzas, J Edward

“…Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal…”
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Stage- and scenario-wise Fenchel decomposition for stochastic mixed 0-1 programs with special structure by Beier, Eric, Venkatachalam, Saravanan, Corolli, Luca, Ntaimo, Lewis

“…Solving stochastic integer programs (SIPs) is generally difficult. This paper considers a comparative study of stage- and scenario-wise Fenchel decomposition…”
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Effects of combined exposure to lead and high-fat diet on bone quality in juvenile male mice by Beier, Eric E, Inzana, Jason A, Sheu, Tzong-Jen, Shu, Lei, Puzas, J. Edward, Mooney, Robert A

“…BACKGROUND: Lead (Pb) exposure and obesity are co-occurring risk factors for decreased bone mass in the young, particularly in low socioeconomic communities…”
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Heavy Metal Ion Regulation of Gene Expression by Beier, Eric E., Sheu, Tzong-jen, Dang, Deborah, Holz, Jonathan D., Ubayawardena, Resika, Babij, Philip, Puzas, J. Edward

“…Exposure to lead (Pb) from environmental sources remains an overlooked and serious public health risk. Starting in childhood, Pb in the skeleton can disrupt…”
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Lead Exposure Decreases BMD as Measured by DXA and Micro CT in an In Vivo Rat Model by Muzytchuk, Catherine, Beier, Eric, Puzas, J. Edward

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Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-β signaling by Holz, Jonathan D., Beier, Eric, Sheu, Tzong-Jen, Ubayawardena, Resika, Wang, Meina, Sampson, Erik R., Rosier, Randy N., Zuscik, Michael, Puzas, J. Edward

“…Lead remains a significant environmental toxin, and we believe we may have identified a novel target of lead toxicity in articular chondrocytes. These cells…”
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Lead Inhibits Skeletal Wnt Signaling and Manifests in Osteoporosis by Beier, Eric E

“…Purpose: Exposure to lead (Pb) from environmental sources remains an overlooked, but serious public health risk. We believe that intoxication from Pb, starting…”
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Occupational Risk Factors and Back Injury by Craig, Brian N., Congleton, Jerome J., Beier, Eric, Kerk, Carter J., Amendola, Alfred A., Gaines, William G.

“…Twenty-one risk factors affecting laborers in manual materials handling tasks were analyzed to determine what, if any, statistically significant relationships…”
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Subgradient-based decomposition methods for stochastic mixed-integer programs with special structures by Beier, Eric Benjamin

“…The focus of this dissertation is solution strategies for stochastic mixed-integer programs with special structures. Motivation for the methods comes from the…”
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Nodal decomposition-coordination for stochastic programs with private information restrictions by Beier, Eric, Venkatachalam, Saravanan, Leon, V. Jorge, Ntaimo, Lewis

“…We present a nodal decomposition-coordination method for stochastic programs with private data (information) restrictions. We consider coordinated systems…”
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