Association between human polyomavirus infection and brain cancer: A systematic review and meta-analysis

The aim of this study was to investigate the prevalence and potential association between the infection with some members of the polyomaviridae family of viruses and development of the brain tumors. A systematic literature search was performed by finding relevant cross-sectional and case-control stu...

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Published in:	Microbial pathogenesis Vol. 173; p. 105797
Main Authors:	Goudarzi far, Fariba, Tambrchi, Vahid, Nahid samiei, Rahil, Nahid samiei, Mahboubeh, Saadati, Hassan, Moradi, Pouya, Keyvanlou, Zahra, Advay, Shoaib, Nili, Marzie, Abdi, Samaneh, Jamalvandi, Tasnim, Arash letafati, Behzadpour, Maral, Kamalpour, Maryam, Ebrahimdamavandi, Niayesh, Khatami, Alireza, Kiani, Seyed Jalal, Ghorbani, Saied
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-12-2022
Subjects:	Brain tumor JCV meta-Analysis Polyomavirus Brain tumor meta-Analysis JCV Polyomavirus
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Summary:	The aim of this study was to investigate the prevalence and potential association between the infection with some members of the polyomaviridae family of viruses and development of the brain tumors. A systematic literature search was performed by finding relevant cross-sectional and case-control studies from a large online database. Heterogeneity, OR, and corresponding 95% CI were applied to all studies by meta-analysis and forest plots. The analysis was performed using Stata Software v.14. Twenty-three articles (33 datasets) were included in the meta-analysis, four (four datasets) of which were case/control studies and the rest were cross-sectional. The pooled prevalence of polyomaviruses among brain cancer patients was 13% (95% CI: 8–20%; I2 = 96.91%). In subgroup analysis, the pooled prevalence of JCV, SV40, BKV and Merkel cell polyomavirus was 20%, 8%, 6%, and 16%, respectively. An association was found between polyomavirus infection and brain cancer [summary OR 7.22 (95% CI (2.36–22.05); I2 = 0%)]. The subgroup analysis, based on the virus type, demonstrated a strong association between JCV infection and brain cancer development [summary OR 10.34 (95% CI 1.10–97.42; I2 = 0%)]. The present study showed a significant association between polyomavirus infection and brain tumors. Moreover, these results suggest that polyomavirus infection may be a potential risk factor for the development of brain cancer. •The pooled prevalence of polyomaviruses among brain cancer patients was 13% (95% CI: 8–20%; I2 = 96.91%).•In subgroup analysis, the pooled prevalence of JCV, SV40, BKV and Merkel cell polyomavirus among brain cancer patients was 20%, 8%, 6%, and 16%, respectively.•An association of polyomavirus infection with brain cancer was [summary OR 7.22 (95% CI (2.36–22.05); I2 = 0%)].•An association of JCV infection with brain cancer was [summary OR 10.34 (95% CI 1.10–97.42; I2 = 0%)].•The present study showed a significant association between polyomavirus infection and brain tumors.•These results suggest that polyomavirus infection may be a potential risk factor for the development of brain cancer.
Bibliography:	SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Review-1 ObjectType-Article-3 ObjectType-Undefined-4
ISSN:	0882-4010 1096-1208
DOI:	10.1016/j.micpath.2022.105797