Search Results - "Behrens, Edward M."

UnDRESSing Systemic Juvenile Idiopathic Arthritis Lung Disease by Behrens, Edward M

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On the Alert for Cytokine Storm: Immunopathology in COVID‐19 by Henderson, Lauren A., Canna, Scott W., Schulert, Grant S., Volpi, Stefano, Lee, Pui Y., Kernan, Kate F., Caricchio, Roberto, Mahmud, Shawn, Hazen, Melissa M., Halyabar, Olha, Hoyt, Kacie J., Han, Joseph, Grom, Alexei A., Gattorno, Marco, Ravelli, Angelo, Benedetti, Fabrizio, Behrens, Edward M., Cron, Randy Q., Nigrovic, Peter A.

“…Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted…”
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Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition by Canna, Scott W., MD, Girard, Charlotte, MD, Malle, Louise, BS, de Jesus, Adriana, MD, PhD, Romberg, Neil, MD, Kelsen, Judith, MD, Surrey, Lea F., MD, Russo, Pierre, MD, Sleight, Andrew, PhD, Schiffrin, Eduardo, MD, Gabay, Cem, MD, Goldbach-Mansky, Raphaela, MD, MHS, Behrens, Edward M., MD

“…Clinical application of several rapidly evolving technologies-next-generation DNA sequencing, biomarker discovery, and targeted cytokine blockade-has been…”
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Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis by Das, Rupali, Guan, Peng, Sprague, Leslee, Verbist, Katherine, Tedrick, Paige, An, Qi Angel, Cheng, Cheng, Kurachi, Makoto, Levine, Ross, Wherry, E. John, Canna, Scott W., Behrens, Edward M., Nichols, Kim E.

“…Hemophagocytic lymphohistiocytosis (HLH) comprises an emerging spectrum of inherited and noninherited disorders of the immune system characterized by the…”
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Hyperinflammation, rather than hemophagocytosis, is the common link between macrophage activation syndrome and hemophagocytic lymphohistiocytosis by Weaver, Lehn K, Behrens, Edward M

“…PURPOSE OF REVIEWMacrophage activation syndrome is the rheumatic disease-associated member of a group of hyperinflammatory syndromes characterized by…”
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Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice by Behrens, Edward M, Canna, Scott W, Slade, Katharine, Rao, Sheila, Kreiger, Portia A, Paessler, Michele, Kambayashi, Taku, Koretzky, Gary A

“…Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are 2 similar diseases characterized by a cytokine storm, overwhelming…”
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Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era by Behrens, Edward M, Koretzky, Gary A

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Pediatric acute liver failure of undetermined cause: A research workshop by Alonso, Estella M., Horslen, Simon P., Behrens, Edward M., Doo, Edward

“…Pediatric acute liver failure (PALF) is a potentially devastating condition that occurs in previously healthy children of all ages and frequently leads to a…”
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Muscularis macrophage development in the absence of an enteric nervous system by Avetisyan, Marina, Rood, Julia E., Lopez, Silvia Huerta, Sengupta, Rajarshi, Wright-Jin, Elizabeth, Dougherty, Joseph D., Behrens, Edward M., Heuckeroth, Robert O.

“…The nervous system of the bowel regulates the inflammatory phenotype of tissue resident muscularis macrophages (MM), and in adult mice, enteric neurons are the…”
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CXCL9 inhibition does not ameliorate disease in murine models of both primary and secondary hemophagocytic lymphohistiocytosis by Diamond, Tamir, Lau, Michelle, Morrissette, Jeremy, Chu, Niansheng, Behrens, Edward M.

“…Hemophagocytic Lymphohistiocytosis (HLH) is a group of disorders culminating in systemic inflammation and multi-organ failure with high incidence of hepatic…”
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Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis by BEHRENS, Edward M, BEUKELMAN, Timothy, PAESSLER, Michele, CRON, Randy Q

“…OBJECTIVE: Macrophage activation syndrome (MAS) is a well described, but purportedly uncommon manifestation of systemic juvenile idiopathic arthritis (SJIA)…”
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Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion by Choa, Ruth, Tohyama, Junichiro, Wada, Shogo, Meng, Hu, Hu, Jian, Okumura, Mariko, May, Rebecca M, Robertson, Tanner F, Pai, Ruth-Anne Langan, Nace, Arben, Hopkins, Christian, Jacobsen, Elizabeth A, Haldar, Malay, FitzGerald, Garret A, Behrens, Edward M, Minn, Andy J, Seale, Patrick, Cotsarelis, George, Kim, Brian, Seykora, John T, Li, Mingyao, Arany, Zoltan, Kambayashi, Taku

“…Emerging studies indicate that the immune system can regulate systemic metabolism. Here, we show that thymic stromal lymphopoietin (TSLP) stimulates T cells to…”
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Measuring cytotoxicity by bioluminescence imaging outperforms the standard chromium-51 release assay by Karimi, Mobin A, Lee, Eric, Bachmann, Michael H, Salicioni, Ana Maria, Behrens, Edward M, Kambayashi, Taku, Baldwin, Cynthia L

“…The chromium-release assay developed in 1968 is still the most commonly used method to measure cytotoxicity by T cells and by natural killer cells. Target…”
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Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction by Diorio, Caroline, Shraim, Rawan, Vella, Laura A., Giles, Josephine R., Baxter, Amy E., Oldridge, Derek A., Canna, Scott W., Henrickson, Sarah E., McNerney, Kevin O., Balamuth, Frances, Burudpakdee, Chakkapong, Lee, Jessica, Leng, Tomas, Farrel, Alvin, Lambert, Michele P., Sullivan, Kathleen E., Wherry, E. John, Teachey, David T., Bassiri, Hamid, Behrens, Edward M.

“…Multi-system Inflammatory Syndrome in Children (MIS-C) is a major complication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in…”
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Making Sense of the Cytokine Storm: A Conceptual Framework for Understanding, Diagnosing, and Treating Hemophagocytic Syndromes by Canna, Scott W., MD, Behrens, Edward M., MD

“…Cytokine storm syndromes (CSS) are a group of disorders representing a variety of inflammatory causes. The clinical presentations of all CSS can be strikingly…”
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Effector memory CD8 T-cells as a novel peripheral blood biomarker for activated T-cell pediatric acute liver failure by Chapin, Catherine A, Burn, Thomas M, Diamond, Tamir, Loomes, Kathleen M, Alonso, Estella M, Behrens, Edward M

“…A distinct phenotype of pediatric acute liver failure (PALF) has been identified, labeled activated T-cell hepatitis. These patients, previously included…”
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Low-dose biliatresone treatment of pregnant mice causes subclinical biliary disease in their offspring: Evidence for a spectrum of neonatal injury by Gupta, Kapish, Xu, Jimmy P, Diamond, Tamir, de Jong, Iris E M, Glass, Andrew, Llewellyn, Jessica, Theise, Neil D, Waisbourd-Zinman, Orith, Winkler, Jeffrey D, Behrens, Edward M, Mesaros, Clementina, Wells, Rebecca G

“…Biliary atresia is a neonatal disease characterized by damage, inflammation, and fibrosis of the liver and bile ducts and by abnormal bile metabolism. It…”
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c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity by Dar, Asif A., Kim, Dale D., Gordon, Scott M., Klinzing, Kathleen, Rosen, Siera, Guha, Ipsita, Porter, Nadia, Ortega, Yohaniz, Forsyth, Katherine S., Roof, Jennifer, Fazelinia, Hossein, Spruce, Lynn A., Eisenlohr, Laurence C., Behrens, Edward M., Oliver, Paula M.

“…During infection, virus-specific CD8 + T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus-infected cells and…”
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Familial hemophagocytic lymphohistiocytosis hepatitis is mediated by IFN-γ in a predominantly hepatic-intrinsic manner by Diamond, Tamir, Burn, Thomas N, Nishiguchi, Mailyn A, Minichino, Danielle, Chase, Julie, Chu, Niansheng, Kreiger, Portia A, Behrens, Edward M

“…Interferon gamma (IFN-γ) is the main cytokine driving organ dysfunction in Familial Hemophagocytic Lymphohistiocytosis (FHL). Blockade of IFN-γ pathway…”
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Genetic Defects in Cytolysis in Macrophage Activation Syndrome by Zhang, Mingce, Behrens, Edward M., Atkinson, T. Prescott, Shakoory, Bita, Grom, Alexei A., Cron, Randy Q.

“…Macrophage activation syndrome (MAS), typically presenting beyond the first year of life, is an often lethal cousin of familial hemophagocytic…”
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