Search Results - "Behr, T. M"

Combination of ‘idiopathic’ REM sleep behaviour disorder and olfactory dysfunction as possible indicator for α-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT by Stiasny-Kolster, K., Doerr, Y., Möller, J. C., Höffken, H., Behr, T. M., Oertel, W. H., Mayer, G.

“…REM sleep behaviour disorder (RBD) and olfactory dysfunction are common and very early features of α-synucleinopathies, in particular Parkinson's disease. To…”
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High-resolution SPECT using multipinhole collimation by Schramm, N.U., Ebel, G., Engeland, U., Schurrat, T., Behe, M., Behr, T.M.

“…The authors present a novel SPECT imaging technique for small animal research based on multipinhole collimation. This new method is an extension of…”
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Quantitative [123I]FP-CIT pinhole SPECT imaging predicts striatal dopamine levels, but not number of nigral neurons in different mouse models of Parkinson's disease by Alvarez-Fischer, D., Blessmann, G., Trosowski, C., Béhé, M., Schurrat, T., Hartmann, A., Behr, T.M., Oertel, W.H., Höglinger, G.U., Höffken, H.

“…Single photon emission computed tomography (SPECT) using [123I]FP-CIT as radioligand for the dopamine transporter has become a widely used tool to monitor the…”
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Reducing the renal uptake of radiolabeled antibody fragments and peptides for diagnosis and therapy: present status, future prospects and limitations by Behr, T M, Goldenberg, D M, Becker, W

“…Elevated renal uptake and prolonged retention of radiolabeled antibody fragments and peptides is a problem in the therapeutic application of such agents. Over…”
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Radiolabeled Peptides for Targeting Cholecystokinin-B/Gastrin Receptor-Expressing Tumors by Behr, Thomas M, Jenner, Niels, Behe, Martin, Angerstein, Christa, Gratz, Stefan, Raue, Friedhelm, Becker, Wolfgang

“…The high sensitivity of pentagastrin stimulation in detecting primary or metastatic medullary thyroid cancer (MTC) suggests widespread expression of the…”
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Incidental Non-Secreting Adrenal Masses in Cancer Patients: Intra-Individual Comparison of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography with Computed Tomography and Shift Magnetic Resonance Imaging by Gratz, S, Kemke, B, Kaiser, W, Heinis, J, Behr, TM, Höffken, H

“…The ability of integrated 18F-fluoro-deoxyglucose positron emission tomography and computed tomography (FDG PET/CT) to distinguish between benign and malignant…”
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Development and clinical application of peptide-based radiopharmaceuticals by Gotthardt, M, Boermann, O C, Behr, T M, Béhé, M P, Oyen, W J G

“…Peptide-based radiopharmaceuticals have been introduced into clinical work more than a decade ago. The first and most successful imaging agent to date is the…”
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Therapeutic advantages of Auger electron- over beta-emitting radiometals or radioiodine when conjugated to internalizing antibodies by Behr, T M, Béhé, M, Löhr, M, Sgouros, G, Angerstein, C, Wehrmann, E, Nebendahl, K, Becker, W

“…Recent studies suggest a higher anti-tumour efficacy of internalizing monoclonal antibodies (MAbs) when labelled with Auger electron emitters, as compared with…”
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Drug interference with MIBG uptake in a patient with metastatic paraganglioma by ZAPLATNIKOV, K, MENZEL, C, DÖBERT, N, HAMSCHO, N, KRANERT, W. T, GOTTHARD, M, BEHR, T. M, GRÜNWALD, F

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Targeting of cholecystokinin-B/gastrin receptors in vivo: preclinical and initial clinical evaluation of the diagnostic and therapeutic potential of radiolabelled gastrin by Behr, T M, Jenner, N, Radetzky, S, Béhe, M, Gratz, S, Yücekent, S, Raue, F, Becker, W

“…The outstanding sensitivity of pentagastrin in detecting the presence of primary, recurrent or metastatic medullary thyroid cancer (MTC) suggests widespread…”
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LeukoScan for Imaging Infection in Different Clinical Settings: A Retrospective Evaluation and Extended Review of the Literature by GRATZ, S, SCHIPPER, M L, DÖRNER, J, HÖFFKEN, H, BECKER, W, KAISER, J W, BÉHÉ, M, BEHR, T M

“…PURPOSE The aim of the current study was to determine the overall diagnostic accuracy of Tc-99m–labeled antigranulocyte monoclonal antibody Fab’ fragments…”
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99mTc-Labeling and in Vitro and in Vivo Evaluation of HYNIC- and (Nα-His)Acetic Acid-Modified [d-Glu1]-Minigastrin by von Guggenberg, E, Behe, M, Behr, T. M, Saurer, M, Seppi, T, Decristoforo, C

“…Gastrin/CCK-2 receptors are overexpressed in a number of tumors such as medullary thyroid cancer (MTC) and small cell lung cancer (SCLC). Recently…”
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Correlation between radiation dose, synovial thickness, and efficacy of radiosynoviorthesis by Gratz, S, Göbel, D, Behr, T M, Herrmann, A, Becker, W

“…To correlate the therapeutic efficacy of radiosynoviorthesis (RSO) to radiation doses achieved. In 20 patients with known rheumatoid arthritis,…”
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Phase I/II Clinical Radioimmunotherapy with an Iodine-131 -Labeled Anti-Carcinoembryonic Antigen Murine Monoclonal Antibody IgG by Behr, Thomas M, Sharkey, Robert M, Juweid, Malik E, Dunn, Robert M, Vagg, Rae C, Ying, Zhiliang, Zhang, Cun-H, Swayne, Lawrence C, Vardi, Yehuda, Siegel, Jeffry A, Goldenberg, David M

“…The aim of this study was to determine, in a Phase I/II clinical trial, the pharmacokinetics, dosimetry and toxicity, as well as antitumor activity, of the…”
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Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives by BEHR, T. M, SHARKEY, R. M, JUWEID, M. E, BLUMENTHAL, R. D, DUNN, R. M, GRIFFITHS, G. L, BAIR, H.-J, WOLF, F. G, BECKER, W. S, GOLDENBERG, D. M

“…The renal uptake of radiolabeled antibody fragments and peptides is a problem in radioimmunodetection and radioimmunotherapy, especially with intracellular…”
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Experimental studies on the role of antibody fragments in cancer radio‐immunotherapy: Influence of radiation dose and dose rate on toxicity and anti‐tumor efficacy by Behr, Thomas M., Memtsoudis, Stavros, Sharkey, Robert M., Blumenthal, Rosalyn D., Dunn, Robert M., Gratz, Stefan, Wieland, Eberhard, Nebendahl, Klaus, Schmidberger, Heinz, Goldenberg, David M., Becker, Wolfgang

“…Whereas bivalent fragments have been widely used for radio‐immunotherapy, no systematic study has been published on the therapeutic performance of monovalent…”
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Rapid blood clearance of mouse IgG2a and human IgG1 in many nude and nu/+ mouse strains is due to low IgG2a serum concentrations by REDDY, N, GAIK LIN ONG, BEHR, T. M, SHARKEY, R. M, GOLDENBERG, D. M, MATTES, M. J

“…We reported previously that the blood clearance of injected mouse IgG2a was extremely rapid in many strains of nude and nu/+ mice. In an attempt to determine…”
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Improved treatment of medullary thyroid cancer in a nude mouse model by combined radioimmunochemotherapy : Doxorubicin potentiates the therapeutic efficacy of radiolabeled antibodies in a radioresistant tumor type by BEHR, T. M, WULST, E, RADETZKY, S, BLUMENTHAL, R. D, DUNN, R. M, GRATZ, S, RAVE-FRÄNK, M, SCHMIDBERGER, H, RAUE, F, BECKER, W

“…Whereas in advanced metastatic medullary thyroid cancer (MTC), a variety of chemotherapeutic regimens have achieved only limited success clinically, more…”
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Reduction of Renal Uptake of Monoclonal Antibody Fragments by Amino Acid Infusion by Behr, Thomas M, Becker, Wolfgang S, Sharkey, Robert M, Juweid, Malik E, Dunn, Robert M, Bair, Hans-J, Wolf, Friedrich G, Goldenberg, David M

“…The renal uptake of radiolabeled antibody fragments and peptides presents a problem in radioimmunodetection and therapy, compromising lesion sensitivity,…”
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What is the best pre-therapeutic dosimetry for successful radioiodine therapy of multifocal autonomy? by Gotthardt, M, Rubner, C, Bauhofer, A, Berce, F, Oyen, W J G, Goecke, J, Pfestroff, A, Schlieck, A, Corstens, F H, Béhé, M, Behr, T M

“…Dose calculation for radioiodine therapy (RIT) of multifocal autonomies (MFA) is a problem as therapeutic outcome may be worse than in other kinds of…”
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