Sex differences in the association between neck circumference and asthma

Summary Introduction The association between obesity and asthma control/quality of life commonly relies on body mass index (BMI) as the anthropomorphic measure. Due to limitations of BMI and the existence of alternative measures, such as neck circumference (NC), we examined the association between N...

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Published in:	Pediatric pulmonology Vol. 51; no. 9; pp. 893 - 900
Main Authors:	Maltz, Lisa, Matz, Ethan L., Gordish-Dressman, Heather, Pillai, Dinesh K., Teach, Stephen J., Camargo Jr, Carlos A., Hubal, Monica J., Behniwal, Simran, Prosper, Guy D., Certner, Nicole, Marwah, Raman, Mansell, Douglas M., Nwachukwu, Fisayo, Lazaroff, Risa, Tsegaye, Yodit, Freishtat, Robert J.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-09-2016 Wiley Subscription Services, Inc
Subjects:	Adiposity Adolescent Asthma - complications Asthma - diagnosis Asthma - prevention & control Body Mass Index Child Female Humans Male Neck - anatomy & histology Obesity - complications pediatric obesity pediatrics Quality of Life Sex Factors Young Adult adiposity pediatric obesity body mass index pediatrics
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Summary:	Summary Introduction The association between obesity and asthma control/quality of life commonly relies on body mass index (BMI) as the anthropomorphic measure. Due to limitations of BMI and the existence of alternative measures, such as neck circumference (NC), we examined the association between NC and asthma control/quality of life, with particular attention to male–female differences. Materials and Methods The AsthMaP‐2 Project is an observational study of youth with physician–diagnosed asthma. NC was stratified according to age‐ and sex‐specific cutoffs and associated with asthma control (via Asthma Control Test [ACT]) and quality of life (via Integrated Therapeutics Group [ITG]—Asthma Short Form). Results The mean ± SD age was 11.9 ± 3.6 years, and 53% were male (N = 116). The mean BMI percentile was at the 71 ± 28 percentile. Thirty‐one participants (27%) met criteria for high NC. Males with high NC had significantly worse asthma control (P = 0.02) and lower quality of life than those with low NC. No similar association was found for females and the proportion of variability in ACT and ITG was best explained by BMI percentile. Conversely, for males, the proportion of variability in these scores explained by NC was larger than BMI percentile alone (Cohen's f2 = 0.04–0.09, a small to medium effect size). Discussion Among male youth with asthma, combined use of NC and BMI percentile explained asthma control and quality of life better than BMI alone. Future studies of asthma should include measurement of NC and other anthropogenic measures of regional adiposity to clarify sex differences in asthma. Pediatr Pulmonol. 2016; 51:893–900. © 2016 Wiley Periodicals, Inc.
Bibliography:	Clark Charitable Foundation ArticleID:PPUL23381 istex:B820AD6E1222FCA34E39DBFEAC8480ED86D605A7 NIH - No. R01MD007075; No. UL1TR000075 ark:/67375/WNG-SH4V27DB-2 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	8755-6863 1099-0496
DOI:	10.1002/ppul.23381