Search Results - "Behnam, Babak"

The Intricate Role of CXCR4 in Cancer by Chatterjee, Samit, Behnam Azad, Babak, Nimmagadda, Sridhar

“…Chemokines mediate numerous physiological and pathological processes related primarily to cell homing and migration. The chemokine CXCL12, also known as…”
Get full text

PET imaging of distinct brain uptake of a nanobody and similarly-sized PAMAM dendrimers after intra-arterial administration by Lesniak, Wojciech G., Chu, Chengyan, Jablonska, Anna, Behnam Azad, Babak, Zwaenepoel, Olivier, Zawadzki, Michal, Lisok, Ala, Pomper, Martin G., Walczak, Piotr, Gettemans, Jan, Janowski, Miroslaw

“…Introduction We have recently shown that intracerebral delivery of an anti-VEGF monoclonal antibody bevacizumab using an intra-arterial (IA) infusion is more…”
Get full text

Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts by Frésard, Laure, Smail, Craig, Ferraro, Nicole M., Teran, Nicole A., Li, Xin, Smith, Kevin S., Bonner, Devon, Kernohan, Kristin D., Marwaha, Shruti, Zappala, Zachary, Balliu, Brunilda, Davis, Joe R., Liu, Boxiang, Prybol, Cameron J., Kohler, Jennefer N., Zastrow, Diane B., Reuter, Chloe M., Fisk, Dianna G., Grove, Megan E., Davidson, Jean M., Hartley, Taila, Joshi, Ruchi, Strober, Benjamin J., Utiramerur, Sowmithri, Lind, Lars, Ingelsson, Erik, Battle, Alexis, Bejerano, Gill, Bernstein, Jonathan A., Ashley, Euan A., Boycott, Kym M., Merker, Jason D., Wheeler, Matthew T., Montgomery, Stephen B.

“…It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene 1 . The current…”
Get full text

A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors by Chatterjee, Samit, Lesniak, Wojciech G, Gabrielson, Matthew, Lisok, Ala, Wharram, Bryan, Sysa-Shah, Polina, Azad, Babak Behnam, Pomper, Martin G, Nimmagadda, Sridhar

“…Antibodies targeting the PD-1/PD-L1 immune checkpoint lead to tumor regression and improved survival in several cancers. PD-L1 expression in tumors may be…”
Get full text

A comprehensive iterative approach is highly effective in diagnosing individuals who are exome negative by Schoch, Kelly, Spillmann, Rebecca, Tan, Queenie K.-G., McConkie-Rosell, Allyn, Jiang, Yong-Hui, Goldstein, David B., Adams, David R., Allard, Patrick, Ashley, Euan A., Bacino, Carlos A., Beggs, Alan H., Birch, Camille L., Bonner, Devon, Boone, Braden E., Brown, Donna M., Chen, Shan, Coakley, Terra R., Cogan, Joy D., Cooper, Cynthia M., Cope, Heidi, Craigen, William J., Davidson, Jean M., Dayal, Jyoti G., Dell’Angelica, Esteban C., Dipple, Katrina M., Donnell-Fink, Laurel A., Dorrani, Naghmeh, Draper, David D., Dries, Annika M., Eckstein, David J., Emrick, Lisa T., Enns, Gregory M., Esteves, Cecilia, Estwick, Tyra, Fernandez, Liliana, Ferreira, Carlos, Fisher, Paul G., Fogel, Brent L., Friedman, Noah D., Gahl, William A., Goldstein, David B., Gourdine, Jean-Philippe F., Haendel, Melissa, Handley, Lori H., Krasnewich, Donna M., Krier, Joel B., Lazar, Jozef, Levy, Shawn E., Lincoln, Sharyn A., Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., MacRae, Calum A., Majcherska, Marta M., Mamounas, Laura A., Manolio, Teri A., Markello, Thomas C., Marom, Ronit, Martin, Martin G., McConkie-Rosell, Allyn, McCormack, Colleen E., Might, Matthew, Morimoto, Marie, Mulvihill, John J., Murphy, Jennifer L., Muzny, Donna M., Nehrebecky, Michele E., Nelson, Stan F., Newberry, J. Scott, Newman, John H., Nicholas, Sarah K., Pallais, J. Carl, Palmer, Christina GS, Parker, Neil H., Phillips, John A., Postlethwait, John H., Reuter, Chloe M., Sampson, Jacinda B., Scott, Daryl A., Sharma, Prashant, Shashi, Vandana, Silverman, Edwin K., Tifft, Cynthia J., Toro, Camilo, Tran, Alyssa A., Urv, Tiina K., Vogel, Tiphanie P., Wahl, Colleen E., Walsh, Chris A., Wan, Jijun, Wangler, Michael F., Ward, Patricia A., Wheeler, Matthew T., Wolfe, Lynne A., Worthey, Elizabeth A., Yamamoto, Shinya, Yang, Yaping, Yu, Guoyun, Zhao, Chunli, Zheng, Allison

“…Sixty to seventy-five percent of individuals with rare and undiagnosed phenotypes remain undiagnosed after exome sequencing (ES). With standard ES reanalysis…”
Get full text

Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder by Yoon, Wan Hee, Jangam, Sharayu, Davidson, Jean M., Grove, Megan E., Kohler, Jennefer N., Holmes, Matthew, Zhao, Chunli, Contrepois, Kévin, Heyman, Heino M., Webb-Robertson, Bobbie-Jo M., Alejandro, Mercedes E., Allard, Patrick, Balasubramanyam, Ashok, Barseghyan, Hayk, Bican, Anna, Birch, Camille L., Bostwick, Bret L., Briere, Lauren C., Brown, Donna M., Brush, Matthew, Burke, Elizabeth A., Burrage, Lindsay C., Cooper, Cynthia M., Cope, Heidi, Craigen, William J., D’Souza, Precilla, Dayal, Jyoti G., Dell’Angelica, Esteban C., Dorset, Daniel C., Draper, David D., Eckstein, David J., Emrick, Lisa T., Esteves, Cecilia, Estwick, Tyra, Ferreira, Carlos, Glanton, Emily, Godfrey, Rena A., Goldstein, David B., Gould, Sarah E., Gourdine, Jean-Philippe F., Hanchard, Neil A., Herzog, Matthew R., Hom, Jason, Howerton, Ellen M., Huang, Yong, Jacob, Howard J., Jiang, Yong-hui, Johnston, Jean M., Jones, Angela L., Kohane, Isaac S., Krier, Joel B., Lazar, Jozef, Lee, Hane, Levy, Shawn E., Lincoln, Sharyn A., Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., MacRae, Calum A., Majcherska, Marta M., Mamounas, Laura A., Manolio, Teri A., Markello, Thomas C., Marom, Ronit, May, Thomas, McConkie-Rosell, Allyn, McCray, Alexa T., Moretti, Paolo M., Novacic, Donna, Orange, Jordan S., Palmer, Christina G.S., Potocki, Lorraine, Pusey, Barbara N., Robertson, Amy K., Rodan, Lance H., Rosenfeld, Jill A., Samson, Susan L., Schoch, Kelly, Schroeder, Molly C., Shashi, Vandana, Silverman, Edwin K., Sinsheimer, Janet S., Spillmann, Rebecca C., Stong, Nicholas, Tifft, Cynthia J., Tran, Alyssa A., Valivullah, Zaheer M., Ward, Patricia A., Yamamoto, Shinya, Snyder, Michael, Merker, Jason D., Fisher, Paul G., Mayr, Johannes A., Morris, Andrew A., Schelley, Susan, Friederich, Marisa W., Yamamoto, Shinya, Wangler, Michael F., Taylor, Robert W., Bernstein, Jonathan A.

“…ATP synthase, H+ transporting, mitochondrial F1 complex, δ subunit (ATP5F1D; formerly ATP5D) is a subunit of mitochondrial ATP synthase and plays an important…”
Get full text

Ciliated, Mitochondria-Rich Postmitotic Cells are Immune-privileged, and Mimic Immunosuppressive Microenvironment of Tumor-Initiating Stem Cells: From Molecular Anatomy to Molecular Pathway by Behnam, Babak, Fazilaty, Hassan, Ghadyani, Mobina, Fadavi, Pedram, Taghizadeh-Hesary, Farzad

“…Cancer whose major problems are metastasis, treatment resistance, and recurrence is the leading cause of death worldwide. Tumor-initiating stem cells (TiSCs)…”
Get full text

Overcoming Chemotherapy Resistance in Metastatic Cancer: A Comprehensive Review by Eslami, Maryam, Memarsadeghi, Omid, Davarpanah, Ali, Arti, Afshin, Nayernia, Karim, Behnam, Babak

“…The management of metastatic cancer is complicated by chemotherapy resistance. This manuscript provides a comprehensive academic review of strategies to…”
Get full text

Field-transcriptome analyses reveal developmental transitions during flowering in cassava (Manihot esculenta Crantz) by Behnam, Babak, Higo, Asuka, Yamaguchi, Kaho, Tokunaga, Hiroki, Utsumi, Yoshinori, Selvaraj, Michael Gomez, Seki, Motoaki, Ishitani, Manabu, Ceballos, Hernan, Lopez-Lavalle, Luis Augusto Becerra, Tsuji, Hiroyuki

“…Key message We characterized genes that function in the photoperiodic flowering pathway in cassava. Transcriptome analysis of field-grown plants revealed…”
Get full text

SLUG and SOX9 Cooperatively Regulate Tumor Initiating Niche Factors in Breast Cancer by Fazilaty, Hassan, Gardaneh, Mossa, Akbari, Parvin, Zekri, Ali, Behnam, Babak

“…Presence of tumor initiating cells and a proper niche is essential for metastatic colonization. SLUG and SOX9 transcription factors play essential roles in…”
Get full text

Clinical, laboratory data and outcomes of 17 Iranian citrullinemia type 1 patients: Identification of five novel ASS1 gene mutations by Moarefian, Shirin, Zamani, Mahdi, Rahmanifar, Ali, Behnam, Babak, Zaman, Talieh

“…Citrullinemia type 1 is an autosomal recessive metabolic disease caused by ASS1 gene mutations encoding argininosuccinic acid synthetase enzyme which is within…”
Get full text

The combined application of human adipose derived stem cells and chondroitinase ABC in treatment of a spinal cord injury model by Sarveazad, Arash, Babahajian, Asrin, Bakhtiari, Mehrdad, Soleimani, Mansoureh, Behnam, Babak, Yari, Abazar, Akbari, Abolfazl, Yousefifard, Mahmoud, Janzadeh, Atousa, Amini, Naser, Agah, Shahram, Fallah, Ali, Joghataei, Mohammad Taghi

“…Abstract Background Although Stem cell therapy has become a major focus as a new option for management of spinal cord injury (SCI), its effectiveness should be…”
Get full text

An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications by Lesniak, Wojciech G, Azad, Babak Behnam, Chatterjee, Samit, Lisok, Ala, Pomper, Martin G

“…The chemokine receptor 4 (CXCR4) is a promising diagnostic and therapeutic target for the management of various cancers. CXCR4 has been utilized in…”
Get full text

Tau pathology in cognitively normal older adults by Ziontz, Jacob, Bilgel, Murat, Shafer, Andrea T., Moghekar, Abhay, Elkins, Wendy, Helphrey, Jessica, Gomez, Gabriela, June, Danielle, McDonald, Michael A., Dannals, Robert F., Azad, Babak Behnam, Ferrucci, Luigi, Wong, Dean F., Resnick, Susan M.

“…Tau pathology, a hallmark of Alzheimer's disease, is observed in the brains of virtually all individuals over 70 years. Using 18F-AV-1451 (18F-flortaucipir)…”
Get full text

Characterization of the promoter region of an Arabidopsis gene for 9-cis-epoxycarotenoid dioxygenase involved in dehydration-inducible transcription by Behnam, Babak, Iuchi, Satoshi, Fujita, Miki, Fujita, Yasunari, Takasaki, Hironori, Osakabe, Yuriko, Yamaguchi-Shinozaki, Kazuko, Kobayashi, Masatomo, Shinozaki, Kazuo

“…Plants respond to dehydration stress and tolerate water-deficit status through complex physiological and cellular processes. Many genes are induced by water…”
Get full text

Novel mutations in CLN6 cause late-infantile neuronal ceroid lipofuscinosis without visual impairment in two unrelated patients by Chin, Joseph J., Behnam, Babak, Davids, Mariska, Sharma, Prashant, Zein, Wadih M., Wang, Camille, Chepa-Lotrea, Xenia, Gallantine, William Brian, Toro, Camilo, Adams, David R., Tifft, Cynthia J., Gahl, William A., Malicdan, May Christine V.

“…CLN6 is a transmembrane protein located in the endoplasmic reticulum that is involved in lysosomal acidification. Mutations in CLN6 cause late-infantile…”
Get full text

Evaluation of PSMA-Targeted PAMAM Dendrimer Nanoparticles in a Murine Model of Prostate Cancer by Lesniak, Wojciech G, Boinapally, Srikanth, Banerjee, Sangeeta Ray, Behnam Azad, Babak, Foss, Catherine A, Shen, Chentian, Lisok, Ala, Wharram, Bryan, Nimmagadda, Sridhar, Pomper, Martin G

“…The prostate-specific membrane antigen (PSMA) is a validated target for detection and management of prostate cancer (PC). It has also been utilized for…”
Get full text

An optimized radiosynthesis of [18F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH) by Azad, Babak Behnam, Holt, Daniel P., Ravert, Hayden T., Horti, Andrew G., Dannals, Robert F.

“…In this concise practitioner protocol, the radiochemical synthesis of [18F]FNDP suitable for human positron emission tomography studies is described and the…”
Get full text

An optimized isolation protocol yields high‐quality RNA from cassava tissues (Manihot esculenta Crantz) by Behnam, Babak, Bohorquez‐Chaux, Adriana, Castaneda‐Mendez, Oscar Fernando, Tsuji, Hiroyuki, Ishitani, Manabu, Becerra Lopez‐Lavalle, Luis Augusto

“…We developed and modified a precise, rapid, and reproducible protocol isolating high‐quality RNA from tissues of multiple varieties of cassava plants (Manihot…”
Get full text

A rare case of Sjogren-Larsson syndrome with recurrent pneumonia and asthma by Tavasoli, Azita, Sayyahfar, Shirin, Behnam, Babak

“…Sjogren-Larsson syndrome (SLS) is a rare autosomal recessive neurocutaneous disorder with worldwide incidence of 0.4 per 100,000 people. It is characterized by…”
Get full text