Search Results - "Behenna, Douglas C"

Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer by Freeman-Cook, Kevin D, Hoffman, Robert L, Behenna, Douglas C, Boras, Britton, Carelli, Jordan, Diehl, Wade, Ferre, Rose Ann, He, You-Ai, Hui, Andrea, Huang, Buwen, Huser, Nanni, Jones, Rhys, Kephart, Susan E, Lapek, John, McTigue, Michele, Miller, Nichol, Murray, Brion W, Nagata, Asako, Nguyen, Lisa, Niessen, Sherry, Ninkovic, Sacha, O’Doherty, Inish, Ornelas, Martha A, Solowiej, James, Sutton, Scott C, Tran, Khanh, Tseng, Elaine, Visswanathan, Ravi, Xu, Meirong, Zehnder, Luke, Zhang, Qin, Zhang, Cathy, Dann, Stephen

“…Control of the cell cycle through selective pharmacological inhibition of CDK4/6 has proven beneficial in the treatment of breast cancer. Extending this level…”
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Development of (Trimethylsilyl)ethyl Ester Protected Enolates and Applications in Palladium-Catalyzed Enantioselective Allylic Alkylation: Intermolecular Cross-Coupling of Functionalized Electrophiles by Reeves, Corey M., Behenna, Douglas C., Stoltz, Brian M.

“…The development of (trimethylsilyl)­ethyl ester protected enolates is reported. The application of this class of compounds in palladium-catalyzed asymmetric…”
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The Reaction Mechanism of the Enantioselective Tsuji Allylation: Inner-Sphere and Outer-Sphere Pathways, Internal Rearrangements, and Asymmetric C–C Bond Formation by Keith, John A, Behenna, Douglas C, Sherden, Nathaniel, Mohr, Justin T, Ma, Sandy, Marinescu, Smaranda C, Nielsen, Robert J, Oxgaard, Jonas, Stoltz, Brian M, Goddard, William A

“…We use first principles quantum mechanics (density functional theory) to report a detailed reaction mechanism of the asymmetric Tsuji allylation involving…”
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Biology and Chemistry of the Zoanthamine Alkaloids by Behenna, Douglas C, Stockdill, Jennifer L, Stoltz, Brian M

“…Marine natural products have long played an important role in natural products chemistry and drug discovery. Mirroring the rich variety and complicated…”
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Enantioselective Decarboxylative Alkylation Reactions: Catalyst Development, Substrate Scope, and Mechanistic Studies by Behenna, Douglas C., Mohr, Justin T., Sherden, Nathaniel H., Marinescu, Smaranda C., Harned, Andrew M., Tani, Kousuke, Seto, Masaki, Ma, Sandy, Novák, Zoltán, Krout, Michael R., McFadden, Ryan M., Roizen, Jennifer L., Enquist Jr, John A., White, David E., Levine, Samantha R., Petrova, Krastina V., Iwashita, Akihiko, Virgil, Scott C., Stoltz, Brian M.

“…α‐Quaternary ketones are accessed through novel enantioselective alkylations of allyl and propargyl electrophiles by unstabilized prochiral enolate…”
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Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Cyclopentanones by Craig, Robert A, Loskot, Steven A, Mohr, Justin T, Behenna, Douglas C, Harned, Andrew M, Stoltz, Brian M

“…The first general method for the enantioselective construction of all-carbon quaternary centers on cyclopentanones by enantioselective palladium-catalyzed…”
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Unusual Allylpalladium Carboxylate Complexes: Identification of the Resting State of Catalytic Enantioselective Decarboxylative Allylic Alkylation Reactions of Ketones by Sherden, Nathaniel H, Behenna, Douglas C, Virgil, Scott C, Stoltz, Brian M

“…Palladium pop rocks: Hold on to your CO2! Enantioselective palladium‐catalyzed decarboxylative alkylation of ketone enolates proceeds via η1‐σ‐allyl…”
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Catalytic Enantioselective Decarboxylative Protonation by Mohr, Justin T, Nishimata, Toyoki, Behenna, Douglas C, Stoltz, Brian M

“…We report a highly enantioselective, general catalytic system for the facile synthesis of tertiary stereocenters by protonation adjacent to cyclic ketones. The…”
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Synthesis of the Carbocyclic Core of Zoanthenol: Implementation of an Unusual Acid-Catalyzed Cyclization by Behenna, Douglas C., Stockdill, Jennifer L., Stoltz, Brian M.

“…A smokin' hot cyclization! When the racemic cyclization precursor is heated in neat trifluoroacetic acid, an unusual Friedel–Crafts‐type cyclization forms the…”
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Confirmation of the absolute configuration of (−)-aurantioclavine by Behenna, Douglas C., Krishnan, Shyam, Stoltz, Brian M.

“…We confirm our previous assignment of the absolute configuration of (−)-aurantioclavine as 7 R by crystallographically characterizing an advanced 3-bromoindole…”
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Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation by Liu, Yiyang, Liniger, Marc, McFadden, Ryan M, Roizen, Jenny L, Malette, Jacquie, Reeves, Corey M, Behenna, Douglas C, Seto, Masaki, Kim, Jimin, Mohr, Justin T, Virgil, Scott C, Stoltz, Brian M

“…Pd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables the formal total syntheses of a number of "classic" natural…”
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Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation by Korch, Katerina M., Eidamshaus, Christian, Behenna, Douglas C., Nam, Sangkil, Horne, David, Stoltz, Brian M.

“…The asymmetric palladium‐catalyzed decarboxylative allylic alkylation of differentially N‐protected piperazin‐2‐ones allows the synthesis of a variety of…”
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Enantioselective construction of quaternary N-heterocycles by palladium-catalysed decarboxylative allylic alkylation of lactams by Behenna, Douglas C., Liu, Yiyang, Yurino, Taiga, Kim, Jimin, White, David E., Virgil, Scott C., Stoltz, Brian M.

“…The enantioselective synthesis of nitrogen-containing heterocycles ( N -heterocycles) represents a substantial chemical research effort and resonates across…”
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The Enantioselective Tsuji Allylation by Behenna, Douglas C, Stoltz, Brian M

“…The first catalytic enantioselective examples of the Tsuji allylation using enol carbonates and enol silanes are described. The products possess a quaternary…”
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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR by Planken, Simon, Behenna, Douglas C, Nair, Sajiv K, Johnson, Theodore O, Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G, Dinh, Dac M, Edwards, Martin P, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle, Kania, Robert S, Kath, John C, Matthews, Jean, Murray, Brion W, Niessen, Sherry, Orr, Suvi T. M, Pairish, Mason, Sach, Neal W, Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L, Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer

“…Mutant epidermal growth factor receptor (EGFR) is a major driver of non-small-cell lung cancer (NSCLC). Marketed first generation inhibitors, such as…”
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Deracemization of Quaternary Stereocenters by Pd-Catalyzed Enantioconvergent Decarboxylative Allylation of Racemic β-Ketoesters by Mohr, Justin T., Behenna, Douglas C., Harned, Andrew M., Stoltz, Brian M.

“…Stereochemical alchemy! Racemic allyl β‐ketoesters allow the regiocontrolled formation of enolates, where the same catalyst is intimately involved in both the…”
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Complexation of Peptidoglycan Intermediates by the Lipoglycodepsipeptide Antibiotic Ramoplanin: Minimal Structural Requirements for Intermolecular Complexation and Fibril Formation by Cudic, Predrag, Kranz, James K., Behenna, Douglas C., Kruger, Ryan G., Tadesse, Hellina, Wand, A. Joshua, Veklich, Yuri I., Weisel, John W., McCafferty, Dewey G.

“…The peptide antibiotic ramoplanin inhibits bacterial peptidoglycan (PG) biosynthesis by interrupting late-stage membrane-associated glycosyltransferase…”
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A Facile and Modular Synthesis of Phosphinooxazoline Ligands by Tani, Kousuke, Behenna, Douglas C, McFadden, Ryan M, Stoltz, Brian M

“…The copper(I) iodide catalyzed phosphine/aryl halide coupling procedure of Buchwald et al. provides modular, robust, and scaleable access to phosphinooxazoline…”
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Simple Enantioselective Approach to Synthetic Limonoids by Behenna, Douglas C, Corey, E. J

“…An enantioselective and short approach to the synthesis of limonoids has been applied successfully to the simplest limonoid, 2. The carbon atoms of the…”
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Enantioselective Synthesis of Caprolactam and Enone Precursors to the Heterocyclic DEFG Ring System of Zoanthenol by Bagdanoff, Jeffrey T., Behenna, Douglas C., Stockdill, Jennifer L., Stoltz, Brian M.

“…The enantioselective synthesis of both caprolactam and enone synthons for the DEFG ring system of zoanthenol are described. The evolution of this approach…”
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