Search Results - "Behavioural brain research"

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis by O’Mahony, S.M., Clarke, G., Borre, Y.E., Dinan, T.G., Cryan, J.F.

“…•Serotonin is a key neurotransmitter in the brain-gut axis.•The gut microbiome is also critical to the normal functioning of the brain-gut axis.•Behaviour…”
Get full text

Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression by Zhao, Xinnan, Cao, Fengrui, Liu, Qing, Li, Xinsheng, Xu, Guoyang, Liu, Gang, Zhang, Yanli, Yang, Xiaohan, Yi, Shansong, Xu, Fenghua, Fan, Kai, Ma, Jianmei

“…[Display omitted] •LPS and UCMS induced depressive-like states to different degrees.•LPS caused more evident behavioural changes and immune activation.•LPS and…”
Get full text

Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model - are we there yet? by Jesulola, Emmanuel, Micalos, Peter, Baguley, Ian J.

“…•Understanding depression pathophysiology is challenging because varying depression symptomatology cannot be explained by single hypothesis.•Pathophysiologic…”
Get full text

Diabetes mellitus and Alzheimer’s disease: GSK-3β as a potential link by Zhang, Ying, Huang, Nan-qu, Yan, Fei, Jin, Hai, Zhou, Shao-yu, Shi, Jing-shan, Jin, Feng

“…•GSK-3β is involved in the physiological and pathological progress of DM and AD respectively.•In DM, GSK-3β is one of the key factors leading to insulin…”
Get full text

Coping with the forced swim stressor: Current state-of-the-art by Molendijk, Marc L., de Kloet, E. Ronald

“…The forced swim test (FST) for rodents does not model despair or helplessness. It also is not a read-out for depression, anxiety, psychomotor retardation or…”
Get full text

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury by Hou, Yanghao, Wang, Yueting, He, Qi, Li, Lingyu, Xie, Hui, Zhao, Yong, Zhao, Jing

“…The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in inflammation damage in ischemic injury, and the activation of the inflammasome is…”
Get full text

Acute alerting effects of light: A systematic literature review by Souman, Jan L., Tinga, Angelica M., te Pas, Susan F., van Ee, Raymond, Vlaskamp, Björn N.S.

“…•We identified 68 publications that investigated acute alerting effects of light.•Many studies reported increased subjective alertness with bright white…”
Get full text

Predicting cognitive decline with deep learning of brain metabolism and amyloid imaging by Choi, Hongyoon, Jin, Kyong Hwan

“…For effective treatment of Alzheimer’s disease (AD), it is important to identify subjects who are most likely to exhibit rapid cognitive decline. We aimed to…”
Get full text

Assessing rodent hippocampal involvement in the novel object recognition task. A review by Cohen, Sarah J., Stackman Jr, Robert W.

“…•Recent papers on the role of hippocampus in NOR are reviewed.•Object recognition is a well accepted task for testing rodent nonspatial memory.•Temporary and…”
Get full text

Bifidobacteria modulate cognitive processes in an anxious mouse strain by Savignac, H.M., Tramullas, M., Kiely, B., Dinan, T.G., Cryan, J.F.

“…•B. longum 1714 improves cognition in BALB/c mice.•B. breve 1205 had little or no positive effects on memory.•Neither of the bacteria had an effect on visceral…”
Get full text

NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model by Su, Wen-Jun, Zhang, Yi, Chen, Ying, Gong, Hong, Lian, Yong-Jie, Peng, Wei, Liu, Yun-Zi, Wang, Yun-Xia, You, Zi-Li, Feng, Shi-Jie, Zong, Ying, Lu, Guo-Cai, Jiang, Chun-Lei

“…•CUMS-induced depression-like behavior needs participation of NLRP3 inflammasome.•NLRP3 gene knockout blocks activation of NF-κB protein complex in…”
Get full text

Deep brain stimulation targets for treating depression by Drobisz, Dominik, Damborská, Alena

“…Deep brain stimulation (DBS) is a new therapeutic approach for treatment-resistant depression (TRD). There is a preliminary evidence of the efficacy and safety…”
Get full text

Brief, daily meditation enhances attention, memory, mood, and emotional regulation in non-experienced meditators by Basso, Julia C., McHale, Alexandra, Ende, Victoria, Oberlin, Douglas J., Suzuki, Wendy A.

“…[Display omitted] •Meditation decreased mood disturbance, anxiety, and fatigue.•Meditation enhanced attention, working memory, and recognition…”
Get full text

Probiotic treatment improves the impaired spatial cognitive performance and restores synaptic plasticity in an animal model of Alzheimer's disease by Rezaei Asl, Zahra, Sepehri, Gholamreza, Salami, Mahmoud

“…•Brain dysfunction in Alzheimer's disease (AD) is associated with gut dysbiosis.•Synaptic plasticity (LTP) & maze learning was impaired in animal model of…”
Get full text

The role of serotonin in drug use and addiction by Müller, Christian P., Homberg, Judith R.

“…•We review the role of the serotonergic system in the establishment of psychoactive drug use and transition to addiction.•There is a distinct involvement of…”
Get full text

The cholinergic system in aging and neuronal degeneration by Schliebs, Reinhard, Arendt, Thomas

“…▶ Aging-related cognitive impairments are due to loss of cholinergic function. ▶ In inherited and late AD basal forebrain cholinergic cells degenerate. ▶ Mild…”
Get full text

Neural circuitry for rat recognition memory by Warburton, E.C., Brown, M.W.

“…•We present a summary of findings from object recognition memory tasks revealing the roles played by cortical, hippocampal and thalamic regions.•We report a…”
Get full text

Serotonin controlling feeding and satiety by Voigt, Jörg-Peter, Fink, Heidrun

“…•The role of brain and peripheral serotonin in satiety are reviewed.•The focus is on the role of brain serotonin receptors in the control of…”
Get full text

The structural and functional connectivity of the amygdala: From normal emotion to pathological anxiety by Kim, M. Justin, Loucks, Rebecca A., Palmer, Amy L., Brown, Annemarie C., Solomon, Kimberly M., Marchante, Ashley N., Whalen, Paul J.

“…► Amygdala is extensively interconnected with the medial prefrontal cortex ► Amygdala-prefrontal circuitry is critical in top-down and bottom-up processes ►…”
Get full text

Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases by Morris, Gerwyn, Berk, Michael, Carvalho, André F., Maes, Michael, Walker, Adam J., Puri, Basant K.

“…•Ferroptosis is a major driver of cell death in neurodegenerative diseases e.g. AD.•Oxidative and nitrosative stress adversely affect cellular iron…”
Get full text